Uniprot_ID	Protein_Name	Entry_Name	Tot_Num_Drugs	Gene_Name	Gene_ID	PDB	Pathways_ID	Pathways_Name	GO_Function	GO_Process	GO_Component	Confidence_Score	PDB_dt
Q07869	Peroxisome proliferator-activated receptor alpha	PPARA_HUMAN	45	PPARA	5465	1I7G;1K7L;1KKQ;2NPA;2P54;2REW;2ZNN;3ET1;3FEI;3G8I;3KDT;3KDU;3SP6;3VI8;4BCR;4CI4	hsa03320|hsa04024|hsa04920|hsa04922|hsa04931|hsa04932|hsa05160	PPAR signaling pathway|cAMP signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hepatitis C	drug binding|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|zinc ion binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|steroid hormone receptor activity|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|lipid binding|transcription factor activity, sequence-specific DNA binding|sequence-specific DNA binding|ubiquitin conjugating enzyme binding|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding	cellular lipid metabolic process|enamel mineralization|fatty acid transport|regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-templated|lipoprotein metabolic process|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter|heart development|positive regulation of gluconeogenesis|negative regulation of cholesterol storage|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|negative regulation of macrophage derived foam cell differentiation|behavioral response to nicotine|response to hypoxia|negative regulation of glycolytic process|response to insulin|circadian regulation of gene expression|wound healing|negative regulation of leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of appetite|lipid metabolic process|negative regulation of receptor biosynthetic process|positive regulation of fatty acid beta-oxidation|circadian rhythm|negative regulation of sequestering of triglyceride|intracellular receptor signaling pathway|negative regulation of neuron death|gene expression|epidermis development|negative regulation of protein binding|small molecule metabolic process|negative regulation of inflammatory response|positive regulation of fatty acid oxidation|fatty acid metabolic process|transcription initiation from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter|regulation of circadian rhythm	nucleus|nucleoplasm	0.524	NA
P03372	Estrogen receptor	ESR1_HUMAN	111	ESR1	2099	1A52;1AKF;1ERE;1ERR;1G50;1GWQ;1GWR;1HCP;1HCQ;1L2I;1PCG;1QKT;1QKU;1R5K;1SJ0;1UOM;1X7E;1X7R;1XP1;1XP6;1XP9;1XPC;1XQC;1YIM;1YIN;1ZKY;2AYR;2B1V;2B1Z;2B23;2BJ4;2FAI;2G44;2G5O;2I0J;2IOG;2IOK;2JF9;2JFA;2LLO;2LLQ;2OCF;2OUZ;2P15;2POG;2Q6J;2Q70;2QA6;2QA8;2QAB;2QE4;2QGT;2QGW;2QH6;2QR9;2QSE;2QXM;2QXS;2QZO;2R6W;2R6Y;2YAT;2YJA;3CBM;3CBO;3CBP;3DT3;3ERD;3ERT;3HLV;3HM1;3L03;3OS8;3OS9;3OSA;3Q95;3Q97;3UU7;3UUA;3UUC;3UUD;4AA6;4DMA;4IU7;4IUI;4IV2;4IV4;4IVW;4IVY;4IW6;4IW8;4IWC;4IWF;4JC3;4JDD;4MG5;4MG6;4MG7;4MG8;4MG9;4MGA;4MGB;4MGC;4MGD;4O6F;4PP6;4PPP;4PPS;4PXM;4Q13;4Q50;4TUZ;4TV1;4ZN9;5AAU;5AAV;5AK2	hsa01522|hsa04915|hsa04917|hsa04919|hsa04961|hsa05200|hsa05205|hsa05224	Endocrine resistance|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Endocrine and other factor-regulated calcium reabsorption|Pathways in cancer|Proteoglycans in cancer|Breast cancer	identical protein binding|zinc ion binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|beta-catenin binding|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|transcription factor activity, sequence-specific DNA binding|core promoter sequence-specific DNA binding|steroid hormone receptor activity|ATPase binding|steroid binding|estrogen receptor activity|estrogen response element binding|chromatin binding|RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding|nitric-oxide synthase regulator activity|transcription factor binding|enzyme binding	chromatin remodeling|epithelial cell proliferation involved in mammary gland duct elongation|male gonad development|transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-templated|intracellular steroid hormone receptor signaling pathway|negative regulation of gene expression|response to estradiol|positive regulation of nitric oxide biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|signal transduction|gene expression|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|phospholipase C-activating G-protein coupled receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|intracellular estrogen receptor signaling pathway|regulation of apoptotic process|prostate epithelial cord elongation|response to estrogen|uterus development|antral ovarian follicle growth|transcription initiation from RNA polymerase II promoter|mammary gland branching involved in pregnancy|epithelial cell development|negative regulation of I-kappaB kinase/NF-kappaB signaling|mammary gland alveolus development|vagina development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of nitric-oxide synthase activity|androgen metabolic process|positive regulation of cytosolic calcium ion concentration|positive regulation of phospholipase C activity|regulation of branching involved in prostate gland morphogenesis|regulation of transcription, DNA-templated|positive regulation of fibroblast proliferation|transcription, DNA-templated|cellular response to estradiol stimulus	cytoplasm|Golgi apparatus|nuclear chromatin|transcriptionally active chromatin|membrane|integral component of membrane|nucleus|cytosol|plasma membrane|nucleoplasm	0.3976	NA
P28702	Retinoic acid receptor RXR-beta	RXRB_HUMAN	15	RXRB	6257	1H9U;1UHL	hsa03320|hsa04659|hsa04919|hsa04920|hsa04928|hsa05200|hsa05202|hsa05216|hsa05222|hsa05223|hsa05226	PPAR signaling pathway|Th17 cell differentiation|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer	zinc ion binding|9-cis retinoic acid receptor activity|steroid hormone receptor activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcription factor activity, sequence-specific DNA binding|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	maternal placenta development|ventricular cardiac muscle cell differentiation|gene expression|transcription initiation from RNA polymerase II promoter|in utero embryonic development|cardiac muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus|nucleoplasm	0.3928	NA
P48443	Retinoic acid receptor RXR-gamma	RXRG_HUMAN	10	RXRG	6258	2GL8	hsa03320|hsa04659|hsa04919|hsa04920|hsa04928|hsa05200|hsa05202|hsa05216|hsa05222|hsa05223|hsa05226	PPAR signaling pathway|Th17 cell differentiation|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer	zinc ion binding|steroid hormone receptor activity|9-cis retinoic acid receptor activity|RNA polymerase II regulatory region sequence-specific DNA binding	gene expression|transcription initiation from RNA polymerase II promoter|protein homotetramerization|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	nucleoplasm	0.384	NA
Q03181	Peroxisome proliferator-activated receptor delta	PPARD_HUMAN	25	PPARD	5467	1GWX;1Y0S;2AWH;2B50;2BAW;2ENV;2GWX;2J14;2Q5G;2XYJ;2XYW;2XYX;2ZNP;2ZNQ;3D5F;3DY6;3ET2;3GWX;3GZ9;3OZ0;3PEQ;3SP9;3TKM	hsa03320|hsa04310|hsa05200|hsa05221	PPAR signaling pathway|Wnt signaling pathway|Pathways in cancer|Acute myeloid leukemia	drug binding|zinc ion binding|steroid hormone receptor activity|DNA binding|transcription factor activity, sequence-specific DNA binding|lipid binding|linoleic acid binding|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|sequence-specific DNA binding	negative regulation of transcription from RNA polymerase II promoter|fatty acid transport|gene expression|positive regulation of myoblast proliferation|cholesterol metabolic process|generation of precursor metabolites and energy|decidualization|transcription initiation from RNA polymerase II promoter|positive regulation of skeletal muscle tissue regeneration|positive regulation of fat cell differentiation|glucose transport|glucose metabolic process|regulation of satellite cell proliferation|cellular response to hypoxia|negative regulation of epithelial cell proliferation|apoptotic signaling pathway|adipose tissue development|cell differentiation|fatty acid catabolic process|positive regulation of transcription, DNA-templated|intracellular receptor signaling pathway|keratinocyte migration|apoptotic process|embryo implantation|cell-substrate adhesion|axon ensheathment|wound healing|regulation of transcription from RNA polymerase II promoter|cell proliferation|lipid metabolic process|keratinocyte proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|negative regulation of transcription, DNA-templated|fatty acid beta-oxidation|negative regulation of myoblast differentiation	nucleoplasm|nucleus	0.3079	NA
Q92731	Estrogen receptor beta	ESR2_HUMAN	55	ESR2	2100	1L2J;1NDE;1QKM;1U3Q;1U3R;1U3S;1U9E;1X76;1X78;1X7B;1X7J;1YY4;1YYE;1ZAF;2FSZ;2GIU;2I0G;2JJ3;2NV7;2QTU;2YJD;2YLY;2Z4B;3OLL;3OLS;3OMO;3OMP;3OMQ;4J24;4J26	hsa01522|hsa04915|hsa04917|hsa05200|hsa05224	Endocrine resistance|Estrogen signaling pathway|Prolactin signaling pathway|Pathways in cancer|Breast cancer	zinc ion binding|core promoter sequence-specific DNA binding|estrogen receptor activity|steroid hormone receptor activity|estrogen response element binding|DNA binding|transcription factor activity, sequence-specific DNA binding|steroid binding|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|enzyme binding|receptor antagonist activity|transcription coactivator activity	extracellular negative regulation of signal transduction|gene expression|positive regulation of sequence-specific DNA binding transcription factor activity|transcription initiation from RNA polymerase II promoter|signal transduction|intracellular estrogen receptor signaling pathway|regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of transcription from RNA polymerase II promoter|cell-cell signaling|negative regulation of cell growth	mitochondrion|nucleoplasm|extracellular region|nucleus	0.2799	NA
Q15788	Nuclear receptor coactivator 1	NCOA1_HUMAN	21	NCOA1	8648	1FM6;1FM9;1K4W;1K74;1K7L;1KV6;1N4H;1NQ7;1NRL;1P8D;1PZL;1RDT;1TFC;1U3R;1U3S;1X76;1X78;1X7B;1X7J;1XIU;1XV9;1XVP;1YY4;1YYE;1ZAF;2A3I;2C52;2FVJ;2GTK;2HBH;2HC4;2HCD;2HFP;2NPA;2NV7;2P54;2PRG;3BEJ;3BQD;3CTB;3CWD;3DCT;3DCU;3DR1;3ET1;3ET3;3FEI;3FEJ;3FUR;3FXV;3G8I;3G9E;3GYT;3GYU;3H0A;3HC5;3HC6;3HVL;3IPQ;3IPS;3IPU;3KMR;3LMP;3OKH;3OKI;3OLF;3OLL;3OLS;3OMK;3OMM;3OMO;3OMP;3OMQ;3OOF;3OOK;3P88;3P89;3QT0;3RUT;3RUU;3RVF;3S9S;3T03;3UU7;3UUA;3UUD;3V9Y;3VN2;4DK7;4DK8;4DM6;4DM8;4DQM;4F9M;4FGY;4G1D;4G1Y;4G1Z;4G20;4G21;4G2H;4HEE;4J5X;4JYG;4JYH;4JYI;4MG5;4MG6;4MG7;4MG8;4MG9;4MGA;4MGB;4MGC;4MGD;4RUJ;4RUP;4TUZ;4TV1;4Y29;5A86;5AVI;5AVL	hsa04915|hsa04919|hsa05200|hsa05224	Estrogen signaling pathway|Thyroid hormone signaling pathway|Pathways in cancer|Breast cancer	nuclear hormone receptor binding|chromatin binding|enzyme binding|protein N-terminus binding|ligand-dependent nuclear receptor binding|transcription coactivator activity|histone acetyltransferase activity|RNA polymerase II regulatory region DNA binding|androgen receptor binding|RNA polymerase II transcription coactivator activity|ligand-dependent nuclear receptor transcription coactivator activity	intracellular receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|histone H4 acetylation|hypothalamus development|androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter by galactose|response to progesterone|chromatin organization|cellular response to hormone stimulus|regulation of cellular response to drug|bile acid metabolic process|lactation|cellular lipid metabolic process|bile acid and bile salt transport|hippocampus development|estrous cycle|small molecule metabolic process|cerebellum development|male mating behavior|response to retinoic acid|cellular response to Thyroglobulin triiodothyronine|positive regulation of neuron differentiation|positive regulation of female receptivity|transcription, DNA-templated|positive regulation of apoptotic process|male gonad development|positive regulation of transcription, DNA-templated|labyrinthine layer morphogenesis|cerebral cortex development|response to estradiol|regulation of thyroid hormone mediated signaling pathway	cytoplasm|neuron projection|nucleoplasm|nuclear chromatin	0.2706	NA
P04278	Sex hormone-binding globulin	SHBG_HUMAN	24	SHBG	6462	1D2S;1F5F;1KDK;1KDM;1LHN;1LHO;1LHU;1LHV;1LHW	NA	NA	androgen binding	primary spermatocyte growth	extracellular region|extracellular exosome	0.2515	NA
P11473	Vitamin D3 receptor	VDR_HUMAN	21	VDR	7421	1DB1;1IE8;1IE9;1KB2;1KB4;1KB6;1S0Z;1S19;1TXI;1YNW;2HAM;2HAR;2HAS;2HB7;2HB8;3A2I;3A2J;3A3Z;3A40;3A78;3AUQ;3AUR;3AX8;3AZ1;3AZ2;3AZ3;3B0T;3CS4;3CS6;3KPZ;3M7R;3OGT;3P8X;3TKC;3VHW;3W0A;3W0C;3W0Y;3WGP;3WWR;4G2I;4ITE;4ITF;4PA2	hsa04928|hsa04961|hsa04978|hsa05152	Parathyroid hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Mineral absorption|Tuberculosis	zinc ion binding|calcitriol binding|steroid hormone receptor activity|calcitriol receptor activity|DNA binding|lithocholic acid binding|lithocholic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding	decidualization|mammary gland branching involved in pregnancy|positive regulation of keratinocyte differentiation|calcium ion transport|negative regulation of keratinocyte proliferation|skeletal system development|positive regulation of vitamin D 24-hydroxylase activity|signal transduction|regulation of calcidiol 1-monooxygenase activity|negative regulation of cell proliferation|vitamin D receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|cellular calcium ion homeostasis|positive regulation of gene expression|negative regulation of transcription, DNA-templated|bile acid signaling pathway|lactation|positive regulation of apoptotic process involved in mammary gland involution|cell morphogenesis|gene expression|intestinal absorption|transcription initiation from RNA polymerase II promoter	nucleoplasm|nucleus|receptor complex|RNA polymerase II transcription factor complex	0.2354	NA
Q02127	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	26	DHODH	1723	1D3G;1D3H;2B0M;2BXV;2FPT;2FPV;2FPY;2FQI;2PRH;2PRL;2PRM;2WV8;3F1Q;3FJ6;3FJL;3G0U;3G0X;3KVJ;3KVK;3KVL;3KVM;3U2O;3W7R;3ZWS;3ZWT;4IGH;4JGD;4JS3;4JTS;4JTT;4JTU;4LS0;4LS1;4LS2;4OQV;4RK8;4RKA;4RLI	hsa00240|hsa01100	Pyrimidine metabolism|Metabolic pathways	drug binding|FMN binding|ubiquinone binding|dihydroorotate dehydrogenase activity	response to caffeine|positive regulation of apoptotic process|response to starvation|nucleobase-containing small molecule metabolic process|female pregnancy|pyrimidine nucleobase metabolic process|response to drug|'de novo' pyrimidine nucleobase biosynthetic process|lactation|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process|small molecule metabolic process|regulation of mitochondrial fission	cytoplasm|mitochondrion|neuronal cell body|mitochondrial inner membrane|integral component of membrane|nucleoplasm	0.2322	NA
Q16678	Cytochrome P450 1B1	CP1B1_HUMAN	6	CYP1B1	1545	3PM0	hsa00140|hsa00380|hsa00980|hsa04913|hsa05204|hsa05206	Steroid hormone biosynthesis|Tryptophan metabolism|Metabolism of xenobiotics by cytochrome P450|Ovarian steroidogenesis|Chemical carcinogenesis|MicroRNAs in cancer	iron ion binding|heme binding|monooxygenase activity|aromatase activity|oxygen binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	positive regulation of angiogenesis|positive regulation of JAK-STAT cascade|collagen fibril organization|toxin metabolic process|positive regulation of vascular endothelial growth factor production|epoxygenase P450 pathway|oxidation-reduction process|trabecular meshwork development|arachidonic acid metabolic process|steroid metabolic process|cellular response to hydrogen peroxide|cellular aromatic compound metabolic process|negative regulation of cell proliferation|retinol metabolic process|cell adhesion|intrinsic apoptotic signaling pathway in response to oxidative stress|angiogenesis|blood vessel morphogenesis|omega-hydroxylase P450 pathway|response to toxic substance|sterol metabolic process|negative regulation of NF-kappaB transcription factor activity|xenobiotic metabolic process|endothelial cell migration|regulation of reactive oxygen species metabolic process|estrogen metabolic process|nitric oxide biosynthetic process|visual perception|endothelial cell-cell adhesion|negative regulation of cell adhesion mediated by integrin|retinal metabolic process|small molecule metabolic process|membrane lipid catabolic process|negative regulation of cell migration|cellular response to organic cyclic compound|positive regulation of apoptotic process|retinal blood vessel morphogenesis	mitochondrion|endoplasmic reticulum membrane	0.2057	NA
P11474	Steroid hormone receptor ERR1	ERR1_HUMAN	7	ESRRA	2101	1XB7;2PJL;3D24;3K6P	NA	NA	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|zinc ion binding|steroid hormone receptor activity|DNA binding|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|steroid binding|protein domain specific binding|sequence-specific DNA binding|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	regulation of osteoblast differentiation|regulation of cell proliferation|regulation of osteoclast differentiation|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|organelle organization|mitochondrion organization|intracellular receptor signaling pathway|gene expression|cartilage development|transcription initiation from RNA polymerase II promoter	nucleoplasm|microtubule cytoskeleton|intercellular bridge|nucleus|nucleolus	0.2023	NA
O60488	Long-chain-fatty-acid--CoA ligase 4	ACSL4_HUMAN	3	ACSL4	2182	NA	hsa00061|hsa00071|hsa01100|hsa01212|hsa03320|hsa04146|hsa04216|hsa04714|hsa04920	Fatty acid biosynthesis|Fatty acid degradation|Metabolic pathways|Fatty acid metabolism|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|ATP binding|arachidonate-CoA ligase activity	positive regulation of cell growth|cellular lipid metabolic process|dendritic spine development|embryonic process involved in female pregnancy|response to nutrient|long-chain fatty acid metabolic process|lipid biosynthetic process|negative regulation of prostaglandin secretion|triglyceride biosynthetic process|response to interleukin-15|small molecule metabolic process|fatty acid transport|long-chain fatty-acyl-CoA biosynthetic process|lipid metabolic process	cytoplasm|membrane|neuronal cell body|endoplasmic reticulum membrane|mitochondrial outer membrane|integral component of membrane|extracellular exosome|peroxisomal membrane|ER-mitochondrion membrane contact site|lipid particle	0.2006	NA
Q13133	Oxysterols receptor LXR-alpha	NR1H3_HUMAN	6	NR1H3	10062	1UHL;3IPQ;3IPS;3IPU;5AVI;5AVL	hsa03320|hsa04931|hsa04932|hsa05160	PPAR signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hepatitis C	zinc ion binding|steroid hormone receptor activity|DNA binding|cholesterol binding|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|sequence-specific DNA binding|transcription coactivator activity|sterol response element binding|transcription regulatory region DNA binding	positive regulation of triglyceride biosynthetic process|negative regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter|negative regulation of pancreatic juice secretion|triglyceride homeostasis|positive regulation of receptor biosynthetic process|positive regulation of cellular protein metabolic process|negative regulation of pinocytosis|apoptotic cell clearance|negative regulation of lipid transport|negative regulation of inflammatory response|negative regulation of secretion of lysosomal enzymes|positive regulation of cholesterol homeostasis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cholesterol transport|intracellular receptor signaling pathway|positive regulation of fatty acid biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|cellular response to lipopolysaccharide|regulation of circadian rhythm|cholesterol homeostasis|response to progesterone|gene expression|sterol homeostasis|negative regulation of cholesterol storage|lipid homeostasis|transcription initiation from RNA polymerase II promoter|positive regulation of lipoprotein lipase activity|negative regulation of macrophage derived foam cell differentiation|negative regulation of interferon-gamma-mediated signaling pathway|positive regulation of cholesterol efflux|positive regulation of transcription, DNA-templated|regulation of cholesterol homeostasis	nuclear chromatin|nucleus|receptor complex|RNA polymerase II transcription factor complex|nucleoplasm	0.1973	NA
P10275	Androgen receptor	ANDR_HUMAN	73	AR	367	1E3G;1GS4;1T5Z;1T63;1T65;1XJ7;1XOW;1XQ3;1Z95;2AM9;2AMA;2AMB;2AO6;2AX6;2AX7;2AX8;2AX9;2AXA;2HVC;2OZ7;2PIO;2PIP;2PIQ;2PIR;2PIT;2PIU;2PIV;2PIW;2PIX;2PKL;2PNU;2Q7I;2Q7J;2Q7K;2Q7L;2YHD;2YLO;2YLP;2YLQ;2Z4J;3B5R;3B65;3B66;3B67;3B68;3BTR;3L3X;3L3Z;3RLJ;3RLL;3V49;3V4A;3ZQT;4HLW;4K7A;4OEA;4OED;4OEY;4OEZ;4OFR;4OFU;4OGH;4OH5;4OH6;4OHA;4OIL;4OIU;4OJ9;4OJB;4OK1;4OKB;4OKT;4OKW;4OKX;4OLM;4QL8;4U4K	hsa04114|hsa05200|hsa05215	Oocyte meiosis|Pathways in cancer|Prostate cancer	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|transcription factor binding|zinc ion binding|beta-catenin binding|RNA polymerase II transcription factor binding|ATPase binding|enzyme binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|receptor binding|androgen binding|androgen receptor activity|transcription factor activity, sequence-specific DNA binding|protein dimerization activity|transcription regulatory region DNA binding|chromatin binding	positive regulation of transcription, DNA-templated|transport|positive regulation of cell differentiation|negative regulation of cell proliferation|prostate gland development|cell growth|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|small GTPase mediated signal transduction|positive regulation of cell proliferation|protein oligomerization|cell-cell signaling|signal transduction|sex differentiation|regulation of establishment of protein localization to plasma membrane|transcription, DNA-templated|positive regulation of integrin biosynthetic process|cell proliferation|positive regulation of gene expression|negative regulation of integrin biosynthetic process|gene expression|negative regulation of extrinsic apoptotic signaling pathway|transcription initiation from RNA polymerase II promoter|positive regulation of NF-kappaB transcription factor activity|intracellular receptor signaling pathway|androgen receptor signaling pathway	cytoplasm|protein complex|nucleus|nuclear chromatin|cytosol|nucleoplasm	0.1941	NA
Q09428	ATP-binding cassette sub-family C member 8	ABCC8_HUMAN	13	ABCC8	6833	NA	hsa02010|hsa04911|hsa04930	ABC transporters|Insulin secretion|Type II diabetes mellitus	ATP binding|potassium channel activity|sulfonylurea receptor activity|ATPase activity, coupled to transmembrane movement of substances|ion channel binding	positive regulation of potassium ion transport|energy reserve metabolic process|potassium ion transport|regulation of insulin secretion|cellular response to organic substance|response to drug|response to lipopolysaccharide|potassium ion transmembrane transport|response to insulin|response to zinc ion|synaptic transmission|response to pH|small molecule metabolic process|negative regulation of insulin secretion|transmembrane transport	synaptic vesicle membrane|sarcolemma|plasma membrane|voltage-gated potassium channel complex	0.1886	NA
P36956	Sterol regulatory element-binding protein 1	SRBP1_HUMAN	3	SREBF1	6720	1AM9	hsa04152|hsa04910|hsa04931|hsa04932	AMPK signaling pathway|Insulin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)	RNA polymerase II core promoter proximal region sequence-specific DNA binding|DNA binding|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|transcription factor activity, sequence-specific DNA binding|chromatin binding|sterol response element binding	cholesterol metabolic process|cellular response to starvation|positive regulation of histone deacetylation|response to food|response to glucagon|regulation of heart rate by chemical signal|response to cAMP|regulation of protein targeting to mitochondrion|positive regulation of triglyceride biosynthetic process|lung development|aging|insulin receptor signaling pathway|positive regulation of cholesterol biosynthetic process|response to drug|positive regulation of transcription from RNA polymerase II promoter|lipid biosynthetic process|regulation of protein stability|lipid metabolic process|negative regulation of insulin secretion|cellular response to fatty acid|regulation of transcription from RNA polymerase II promoter|regulation of fatty acid metabolic process|circadian rhythm|response to glucose|small molecule metabolic process|regulation of mitophagy|negative regulation of transcription from RNA polymerase II promoter|response to progesterone|response to retinoic acid	cytoplasm|cytosol|protein complex|nucleoplasm|nuclear envelope|nucleus|ER to Golgi transport vesicle membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi membrane|integral component of membrane	0.1875	NA
P10826	Retinoic acid receptor beta	RARB_HUMAN	9	RARB	5915	1HRA;1XAP;4DM6;4DM8;4JYG;4JYH;4JYI	hsa05200|hsa05222|hsa05223|hsa05226	Pathways in cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer	drug binding|zinc ion binding|steroid hormone receptor activity|DNA binding|retinoic acid receptor activity|sequence-specific DNA binding	embryonic digestive tract development|positive regulation of neuron differentiation|signal transduction|regulation of myelination|gene expression|transcription initiation from RNA polymerase II promoter	nucleoplasm|cytoplasm|nucleus	0.1836	NA
P62508	Estrogen-related receptor gamma	ERR3_HUMAN	15	ESRRG	2104	1KV6;1TFC;1VJB;2E2R;2EWP;2GP7;2GPO;2GPP;2GPU;2GPV;2P7A;2P7G;2P7Z;2ZAS;2ZBS;2ZKC	NA	NA	zinc ion binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|steroid hormone receptor activity|steroid binding|retinoic acid receptor activity|AF-2 domain binding|RNA polymerase II regulatory region sequence-specific DNA binding	gene expression|transcription initiation from RNA polymerase II promoter|regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated	nucleoplasm	0.1725	NA
Q99527	G-protein coupled estrogen receptor 1	GPER1_HUMAN	8	GPER1	2852	NA	hsa01522|hsa04915	Endocrine resistance|Estrogen signaling pathway	drug binding|estrogen receptor activity|G-protein coupled receptor activity|mineralocorticoid receptor activity|steroid binding|chromatin binding|steroid hormone binding	positive regulation of endothelial cell apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of vasodilation|negative regulation of vascular smooth muscle cell proliferation|negative regulation of protein kinase B signaling|cell cycle|positive regulation of insulin secretion|steroid hormone mediated signaling pathway|cellular response to tumor necrosis factor|nuclear fragmentation involved in apoptotic nuclear change|positive regulation of release of sequestered calcium ion into cytosol|cellular response to estradiol stimulus|positive regulation of gene expression|apoptotic chromosome condensation|positive regulation of cell migration|positive regulation of cardiac vascular smooth muscle cell differentiation|positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of establishment of protein localization to plasma membrane|negative regulation of gene expression|negative regulation of cell proliferation|positive regulation of neurotransmitter secretion|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of transcription from RNA polymerase II promoter|negative regulation of inflammatory response|positive regulation of neurogenesis|positive regulation of MAPK cascade|cellular response to glucose stimulus|positive regulation of cAMP biosynthetic process|positive regulation of G-protein coupled receptor protein signaling pathway|mineralocorticoid receptor signaling pathway|positive regulation of uterine smooth muscle contraction|intracellular steroid hormone receptor signaling pathway|innate immune response|positive regulation of epidermal growth factor receptor signaling pathway|negative regulation of cell cycle process|negative regulation of ERK1 and ERK2 cascade|cellular response to mineralocorticoid stimulus|positive regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria|G-protein coupled receptor signaling pathway|negative regulation of DNA metabolic process|cellular response to peptide hormone stimulus|positive regulation of cytosolic calcium ion concentration|cytosolic calcium ion homeostasis|negative regulation of leukocyte activation|negative regulation of cell cycle arrest|neuronal action potential|negative regulation of fat cell differentiation|positive regulation of protein phosphorylation|positive regulation of inositol trisphosphate biosynthetic process|positive regulation of cell proliferation|negative regulation of lipid biosynthetic process|inflammatory response|positive regulation of ERK1 and ERK2 cascade	early endosome|integral component of plasma membrane|presynaptic membrane|intracellular|keratin filament|mitochondrial membrane|cytoplasm|cell junction|postsynaptic density|trans-Golgi network|Golgi apparatus|presynaptic active zone|dendritic spine head|nucleus|dendritic spine membrane|cytosol|Golgi membrane|perinuclear region of cytoplasm|cytoplasmic vesicle membrane|axon terminus|endoplasmic reticulum|recycling endosome|dendrite|plasma membrane|neuronal postsynaptic density|nuclear envelope|axon|endoplasmic reticulum membrane|dendritic shaft	0.1719	NA