Rank	Pathway_ID	Pathway_Name	Total_Gene_Number	Pathway_Class_1st	Pathway_Class_2nd	Gene_Names	Gene_IDs	Num_Targets	P_value_target	P_value_drug
1	hsa04931	Insulin resistance	107	Human Diseases	Endocrine and metabolic diseases	PPARA;NR1H3;SREBF1	5465;10062;6720	3	0.02602182662081811	0.10180044897500463
2	hsa01522	Endocrine resistance	98	Human Diseases	Drug resistance: Antineoplastic	ESR1;GPER1;ESR2	2099;2852;2100	3	0.02602182662081811	0.10616295217711927
3	hsa05224	Breast cancer	147	Human Diseases	Cancers: Specific types	ESR1;NCOA1;ESR2	2099;8648;2100	3	0.038456167505817804	0.10111394248313452
4	hsa04961	Endocrine and other factor-regulated calcium reabsorption	47	Organismal Systems	Excretory system	ESR1;VDR	2099;7421	2	0.038456167505817804	0.08393247178767173
5	hsa04917	Prolactin signaling pathway	70	Organismal Systems	Endocrine system	ESR1;ESR2	2099;2100	2	0.06665237874433698	0.10181067092989338
6	hsa00061	Fatty acid biosynthesis	13	Metabolism	Lipid metabolism	ACSL4	2182	1	0.15090559389451633	0.07899526756487768
7	hsa04913	Ovarian steroidogenesis	49	Organismal Systems	Endocrine system	CYP1B1	1545	1	0.2436774411774257	0.07932718045379489
8	hsa04978	Mineral absorption	51	Organismal Systems	Digestive system	VDR	7421	1	0.2436774411774257	0.07241232860113787
9	hsa01212	Fatty acid metabolism	48	Metabolism	Global and overview maps	ACSL4	2182	1	0.2526646609324245	0.10156534401198546
10	hsa00140	Steroid hormone biosynthesis	59	Metabolism	Lipid metabolism	CYP1B1	1545	1	0.2608943581868079	0.0758605347250013
11	hsa04930	Type II diabetes mellitus	46	Human Diseases	Endocrine and metabolic diseases	ABCC8	6833	1	0.2684177636181468	0.07554706144102266
12	hsa05221	Acute myeloid leukemia	66	Human Diseases	Cancers: Specific types	PPARD	5467	1	0.271596406692923	0.08987726870900445
13	hsa04911	Insulin secretion	85	Organismal Systems	Endocrine system	ABCC8	6833	1	0.27429922283591257	0.08285593853608979
14	hsa04146	Peroxisome	83	Cellular Processes	Transport and catabolism	ACSL4	2182	1	0.27429922283591257	0.0758605347250013
15	hsa00071	Fatty acid degradation	44	Metabolism	Lipid metabolism	ACSL4	2182	1	0.2812132403154266	0.07241232860113787
16	hsa05204	Chemical carcinogenesis	82	Human Diseases	Cancers: Overview	CYP1B1	1545	1	0.2825335245237925	0.08426161873587343
17	hsa00240	Pyrimidine metabolism	101	Metabolism	Nucleotide metabolism	DHODH	1723	1	0.2836480224767474	0.08002118013065536
18	hsa04922	Glucagon signaling pathway	103	Organismal Systems	Endocrine system	PPARA	5465	1	0.2836480224767474	0.07554706144102266
19	hsa00980	Metabolism of xenobiotics by cytochrome P450	76	Metabolism	Xenobiotics biodegradation and metabolism	CYP1B1	1545	1	0.29127198187254844	0.08002118013065536
20	hsa05215	Prostate cancer	97	Human Diseases	Cancers: Specific types	AR	367	1	0.2913897263300073	0.12453845753850826
21	hsa02010	ABC transporters	44	Environmental Information Processing	Membrane transport	ABCC8	6833	1	0.2965126048376886	0.0733527484531006
22	hsa04114	Oocyte meiosis	124	Cellular Processes	Cell growth and death	AR	367	1	0.32019024593333917	0.10464308170936071
23	hsa00380	Tryptophan metabolism	40	Metabolism	Amino acid metabolism	CYP1B1	1545	1	0.329458449819654	0.08111121223179396
24	hsa04910	Insulin signaling pathway	137	Organismal Systems	Endocrine system	SREBF1	6720	1	0.33507589161209295	0.10478964064725187
25	hsa04216	Ferroptosis	40	Cellular Processes	Cell growth and death	ACSL4	2182	1	0.3383777093019947	0.08322715689871034
26	hsa04310	Wnt signaling pathway	146	Environmental Information Processing	Signal transduction	PPARD	5467	1	0.34018532069914	0.08839946608450916
27	hsa05152	Tuberculosis	179	Human Diseases	Infectious diseases: Bacterial	VDR	7421	1	0.3882874895011892	0.09852706449023915
28	hsa04024	cAMP signaling pathway	198	Environmental Information Processing	Signal transduction	PPARA	5465	1	0.3969738751899094	0.18375803907375332
29	hsa05205	Proteoglycans in cancer	201	Human Diseases	Cancers: Overview	ESR1	2099	1	0.3969738751899094	0.12783224332544696
30	hsa05206	MicroRNAs in cancer	299	Human Diseases	Cancers: Overview	CYP1B1	1545	1	0.5177304786142276	0.09852706449023915
31	hsa01100	Metabolic pathways	1293	Metabolism	Global and overview maps	DHODH;ACSL4	1723;2182	2	0.8201895420192715	0.26574444849003975