Uniprot_ID	Protein_Name	Entry_Name	Tot_Num_Drugs	Gene_Name	Gene_ID	PDB	Pathways_ID	Pathways_Name	GO_Function	GO_Process	GO_Component	Confidence_Score	PDB_dt
P18825	Alpha-2C adrenergic receptor	ADA2C_HUMAN	72	ADRA2C	152	NA	hsa04022|hsa04080	cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction	epinephrine binding|alpha2-adrenergic receptor activity|protein heterodimerization activity|protein homodimerization activity|alpha-2A adrenergic receptor binding	regulation of sensory perception of pain|G-protein coupled receptor signaling pathway|blood coagulation|regulation of insulin secretion|activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|adenylate cyclase-inhibiting adrenergic receptor signaling pathway|cell-cell signaling|negative regulation of norepinephrine secretion|epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway|platelet activation|female pregnancy|negative regulation of epinephrine secretion|small molecule metabolic process|negative regulation of adenylate cyclase activity|negative regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of vasoconstriction|negative regulation of uterine smooth muscle contraction|positive regulation of neuron differentiation|energy reserve metabolic process	cytoplasm|plasma membrane|endosome|integral component of plasma membrane|axon terminus	0.8672	NA
P35368	Alpha-1B adrenergic receptor	ADA1B_HUMAN	87	ADRA1B	147	NA	hsa04020|hsa04022|hsa04080|hsa04261|hsa04270|hsa04970	Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion	alpha1-adrenergic receptor activity|protein heterodimerization activity	adenylate cyclase-modulating G-protein coupled receptor signaling pathway|organ growth|G-protein coupled receptor signaling pathway|positive regulation of MAPK cascade|positive regulation of glycogen catabolic process|positive regulation of smooth muscle contraction|visual learning|regulation of cardiac muscle contraction|multicellular organismal development|response to morphine|cell growth|vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure|intracellular signal transduction|adenylate cyclase-activating adrenergic receptor signaling pathway|cell-cell signaling|positive regulation of heart rate by epinephrine-norepinephrine|cell proliferation|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of the force of heart contraction by epinephrine-norepinephrine|locomotory behavior|behavioral response to cocaine|glucose homeostasis|response to amphetamine|blood vessel remodeling|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|adult heart development|positive regulation of cytosolic calcium ion concentration|positive regulation of vasoconstriction|negative regulation of glycogen catabolic process	nucleus|plasma membrane|cytosol|nuclear membrane|integral component of plasma membrane	0.8403	NA
P25100	Alpha-1D adrenergic receptor	ADA1D_HUMAN	68	ADRA1D	146	NA	hsa04020|hsa04022|hsa04080|hsa04261|hsa04270|hsa04970	Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion	alpha1-adrenergic receptor activity	phospholipase C-activating G-protein coupled receptor signaling pathway|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|cell-cell signaling|positive regulation of vasoconstriction|cell proliferation|DNA metabolic process|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|adenylate cyclase-activating adrenergic receptor signaling pathway|negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure|G-protein coupled receptor signaling pathway|positive regulation of smooth muscle contraction|multicellular organismal development|positive regulation of cell proliferation	plasma membrane|cytosol|integral component of plasma membrane	0.8249	NA
P28335	5-hydroxytryptamine receptor 2C	5HT2C_HUMAN	72	HTR2C	3358	NA	hsa04020|hsa04080|hsa04540|hsa04726|hsa04750	Calcium signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Serotonergic synapse|Inflammatory mediator regulation of TRP channels	drug binding|serotonin binding|1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|Gq/11-coupled serotonin receptor activity|serotonin receptor activity	phospholipase C-activating serotonin receptor signaling pathway|serotonin receptor signaling pathway|positive regulation of phosphatidylinositol biosynthetic process|response to drug|positive regulation of fat cell differentiation|regulation of corticotropin-releasing hormone secretion|cellular calcium ion homeostasis|regulation of neurological system process|synaptic transmission|positive regulation of ERK1 and ERK2 cascade|release of sequestered calcium ion into cytosol|behavioral fear response|phospholipase C-activating G-protein coupled receptor signaling pathway|feeding behavior|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|locomotory behavior|cGMP biosynthetic process|regulation of appetite	plasma membrane|cytosol|integral component of plasma membrane	0.6361	NA
P08908	5-hydroxytryptamine receptor 1A	5HT1A_HUMAN	87	HTR1A	3350	NA	hsa04024|hsa04080|hsa04726|hsa04742	cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction	serotonin receptor activity	regulation of behavior|cell proliferation|serotonin metabolic process|exploration behavior|G-protein coupled receptor signaling pathway|regulation of serotonin secretion|positive regulation of cell proliferation|adenylate cyclase-inhibiting serotonin receptor signaling pathway|serotonin receptor signaling pathway|behavioral fear response|regulation of dopamine metabolic process|regulation of hormone secretion|vasoconstriction	plasma membrane|integral component of plasma membrane	0.6242	NA
P28223	5-hydroxytryptamine receptor 2A	5HT2A_HUMAN	112	HTR2A	3356	NA	hsa04020|hsa04080|hsa04540|hsa04726|hsa04750	Calcium signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Serotonergic synapse|Inflammatory mediator regulation of TRP channels	drug binding|1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|virus receptor activity|serotonin binding|serotonin receptor activity	regulation of hormone secretion|serotonin receptor signaling pathway|memory|response to drug|detection of mechanical stimulus involved in sensory perception of pain|urinary bladder smooth muscle contraction|aging|phosphatidylinositol 3-kinase signaling|cell death|positive regulation of fat cell differentiation|protein localization to cytoskeleton|detection of temperature stimulus involved in sensory perception of pain|artery smooth muscle contraction|cellular calcium ion homeostasis|negative regulation of synaptic transmission, glutamatergic|synaptic transmission|temperature homeostasis|phospholipase C-activating serotonin receptor signaling pathway|activation of phospholipase C activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of vasoconstriction|positive regulation of glycolytic process|release of sequestered calcium ion into cytosol|positive regulation of MAP kinase activity|behavioral response to cocaine|positive regulation of cell proliferation|regulation of behavior|negative regulation of potassium ion transport|sleep|positive regulation of ERK1 and ERK2 cascade|regulation of dopamine secretion	neuronal cell body|dendritic shaft|caveola|plasma membrane|cytoplasmic membrane-bounded vesicle|cytosol|axon|integral component of plasma membrane|cell body fiber	0.5829	NA
P28221	5-hydroxytryptamine receptor 1D	5HT1D_HUMAN	37	HTR1D	3352	NA	hsa04024|hsa04080|hsa04726|hsa04742	cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction	serotonin receptor activity|serotonin binding	intestine smooth muscle contraction|synaptic transmission|regulation of behavior|regulation of locomotion|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|serotonin receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|response to toxic substance|vasoconstriction	plasma membrane|integral component of plasma membrane	0.5655	NA
P41595	5-hydroxytryptamine receptor 2B	5HT2B_HUMAN	42	HTR2B	3357	4IB4;4NC3	hsa04020|hsa04080|hsa04540|hsa04726|hsa04750	Calcium signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Serotonergic synapse|Inflammatory mediator regulation of TRP channels	drug binding|GTPase activator activity|serotonin receptor activity|serotonin binding|G-protein alpha-subunit binding	positive regulation of nitric-oxide synthase activity|neural crest cell differentiation|positive regulation of phosphatidylinositol biosynthetic process|G-protein coupled receptor internalization|positive regulation of ERK1 and ERK2 cascade|release of sequestered calcium ion into cytosol|G-protein coupled receptor signaling pathway|cardiac muscle hypertrophy|negative regulation of cell death|response to drug|positive regulation of cell proliferation|positive regulation of cytokine production|neural crest cell migration|intestine smooth muscle contraction|protein kinase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|regulation of behavior|phosphorylation|calcium-mediated signaling|protein kinase C signaling|positive regulation of cell division|heart morphogenesis|behavior|embryonic morphogenesis|positive regulation of I-kappaB kinase/NF-kappaB signaling|serotonin receptor signaling pathway|cellular response to amine stimulus|ERK1 and ERK2 cascade|cellular calcium ion homeostasis|cellular response to serotonin|phosphatidylinositol 3-kinase signaling|ion transmembrane transport|negative regulation of autophagy|activation of phospholipase C activity|cellular response to temperature stimulus|vasoconstriction|negative regulation of apoptotic process|positive regulation of MAP kinase activity|hepatic stellate cell activation|cGMP biosynthetic process|inositol phosphate metabolic process	synapse|cytoplasm|neuronal cell body|plasma membrane|cell junction|integral component of plasma membrane|dendrite	0.5571	NA
P50406	5-hydroxytryptamine receptor 6	5HT6R_HUMAN	28	HTR6	3362	NA	hsa04020|hsa04024|hsa04080|hsa04726	Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse	histamine receptor activity|serotonin receptor activity	synaptic transmission|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|cerebral cortex cell migration|positive regulation of TOR signaling	plasma membrane|integral component of plasma membrane|cilium	0.5492	NA
P34969	5-hydroxytryptamine receptor 7	5HT7R_HUMAN	37	HTR7	3363	NA	hsa04014|hsa04020|hsa04080|hsa04726	Ras signaling pathway|Calcium signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse	serotonin receptor activity	synaptic transmission|blood circulation|smooth muscle contraction|circadian rhythm|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|serotonin receptor signaling pathway|vasoconstriction	plasma membrane|integral component of plasma membrane	0.5464	NA
P21917	D(4) dopamine receptor	DRD4_HUMAN	36	DRD4	1815	NA	hsa04080|hsa04728	Neuroactive ligand-receptor interaction|Dopaminergic synapse	drug binding|dopamine binding|dopamine neurotransmitter receptor activity|G-protein coupled amine receptor activity|SH3 domain binding|identical protein binding|dopamine neurotransmitter receptor activity, coupled via Gi/Go|potassium channel regulator activity	retina development in camera-type eye|adenylate cyclase-inhibiting dopamine receptor signaling pathway|circadian rhythm|positive regulation of excitatory postsynaptic potential|adult locomotory behavior|positive regulation of kinase activity|arachidonic acid secretion|positive regulation of penile erection|dopamine receptor signaling pathway|behavioral fear response|positive regulation of sodium|fear response|synaptic transmission|behavioral response to ethanol|cellular calcium ion homeostasis|regulation of calcium-mediated signaling|behavioral response to cocaine|negative regulation of cAMP biosynthetic process|synaptic transmission, dopaminergic|regulation of dopamine metabolic process|regulation of circadian rhythm|negative regulation of protein secretion|negative regulation of adenylate cyclase activity|regulation of neurotransmitter secretion|inhibitory postsynaptic potential|negative regulation of voltage-gated calcium channel activity|response to histamine|social behavior|sensory perception of chemical stimulus|olfactory learning|response to steroid hormone|dopamine metabolic process|photoperiodism|short-term memory|activation of MAPK activity|response to amphetamine|positive regulation of dopamine uptake involved in synaptic transmission	dendritic spine|membrane|terminal bouton|plasma membrane|vesicle membrane|integral component of plasma membrane|cell cortex|neuronal cell body	0.5417	NA
P28222	5-hydroxytryptamine receptor 1B	5HT1B_HUMAN	43	HTR1B	3351	2G1X;4IAQ;4IAR	hsa04024|hsa04080|hsa04726|hsa04742	cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction	drug binding|serotonin binding|serotonin receptor activity	cellular response to alkaloid|cellular response to drug|cellular response to temperature stimulus|response to ethanol|negative regulation of serotonin secretion|drinking behavior|adenylate cyclase-inhibiting serotonin receptor signaling pathway|synaptic transmission|negative regulation of synaptic transmission, glutamatergic|response to mineralocorticoid|protein kinase C-activating G-protein coupled receptor signaling pathway|negative regulation of cAMP biosynthetic process|vasoconstriction|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|regulation of behavior|negative regulation of synaptic transmission, GABAergic|regulation of dopamine secretion|bone remodeling|G-protein coupled receptor internalization|response to cocaine	cytoplasm|plasma membrane|integral component of plasma membrane	0.5376	NA
P35367	Histamine H1 receptor	HRH1_HUMAN	104	HRH1	3269	3RZE	hsa04020|hsa04080|hsa04750	Calcium signaling pathway|Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels	histamine binding|G-protein coupled receptor activity|histamine receptor activity	modulation of synaptic transmission|positive regulation of vasoconstriction|memory|regulation of synaptic plasticity|inflammatory response|visual learning|regulation of vasoconstriction|positive regulation of inositol trisphosphate biosynthetic process|cellular response to histamine|regulation of vascular permeability|G-protein coupled receptor signaling pathway|eosinophil chemotaxis|sensory perception of chemical stimulus|inositol phosphate-mediated signaling|phospholipase C-activating G-protein coupled receptor signaling pathway	cytoplasm|plasma membrane|nucleoplasm|integral component of plasma membrane	0.5339	NA
P35462	D(3) dopamine receptor	DRD3_HUMAN	50	DRD3	1814	3PBL	hsa04080|hsa04728	Neuroactive ligand-receptor interaction|Dopaminergic synapse	drug binding|dopamine neurotransmitter receptor activity, coupled via Gi/Go|dopamine binding|G-protein coupled amine receptor activity	response to cocaine|negative regulation of dopamine receptor signaling pathway|regulation of blood volume by renin-angiotensin|musculoskeletal movement, spinal reflex action|response to amphetamine|negative regulation of oligodendrocyte differentiation|synaptic transmission, dopaminergic|negative regulation of sodium|regulation of locomotion involved in locomotory behavior|response to drug|negative regulation of transcription from RNA polymerase II promoter|G-protein coupled receptor internalization|negative regulation of adenylate cyclase activity|adenylate cyclase-inhibiting dopamine receptor signaling pathway|regulation of lipid metabolic process|positive regulation of renal sodium excretion|arachidonic acid secretion|synaptic transmission|regulation of multicellular organism growth|negative regulation of protein kinase B signaling|social behavior|negative regulation of protein secretion|acid secretion|positive regulation of mitotic nuclear division|response to histamine|positive regulation of transcription from RNA polymerase II promoter|regulation of circadian sleep/wake cycle, sleep|G-protein coupled receptor signaling pathway|positive regulation of cytokinesis|adenylate cyclase-activating dopamine receptor signaling pathway|regulation of cAMP metabolic process|sensory perception of chemical stimulus|learning or memory|cellular calcium ion homeostasis|positive regulation of dopamine receptor signaling pathway|visual learning|positive regulation of cell proliferation|prepulse inhibition|learning|regulation of dopamine uptake involved in synaptic transmission|response to morphine|dopamine metabolic process|regulation of dopamine secretion|negative regulation of blood pressure|gastric emptying|behavioral response to cocaine|locomotory behavior|circadian regulation of gene expression	plasma membrane|endocytic vesicle|integral component of plasma membrane|apical part of cell|cell projection	0.5321	NA
P21728	D(1A) dopamine receptor	DRD1_HUMAN	63	DRD1	1812	1OZ5	hsa04020|hsa04024|hsa04080|hsa04540|hsa04728|hsa05012|hsa05030|hsa05031|hsa05032|hsa05034	Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Dopaminergic synapse|Parkinson disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism	drug binding|dopamine binding|dopamine neurotransmitter receptor activity|dopamine neurotransmitter receptor activity, coupled via Gs|G-protein coupled amine receptor activity	response to amphetamine|response to ethanol|regulation of long-term neuronal synaptic plasticity|regulation of dopamine uptake involved in synaptic transmission|positive regulation of potassium ion transport|positive regulation of cell migration|sensitization|prepulse inhibition|striatum development|response to nicotine|astrocyte development|response to antidepressant|temperature homeostasis|response to estradiol|synaptic transmission, dopaminergic|orbitofrontal cortex development|response to activity|protein import into nucleus|adult walking behavior|response to drug|activation of adenylate cyclase activity|maternal behavior|positive regulation of synaptic transmission, glutamatergic|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|glucose import|visual learning|social behavior|conditioned taste aversion|positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|cerebral cortex GABAergic interneuron migration|response to morphine|sensory perception of chemical stimulus|neuronal action potential|vasodilation|dentate gyrus development|behavioral response to cocaine|transmission of nerve impulse|adenylate cyclase-activating dopamine receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|cellular response to insulin stimulus|habituation|synapse assembly|regulation of vasoconstriction|adenylate cyclase-activating G-protein coupled receptor signaling pathway|calcium-mediated signaling|cellular response to hypoxia|positive regulation of membrane potential|dopamine transport|positive regulation of long-term synaptic potentiation|cellular response to catecholamine stimulus|behavioral fear response|negative regulation of protein kinase activity|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|memory|positive regulation of feeding behavior|positive regulation of cAMP biosynthetic process|learning|regulation of dopamine metabolic process|response to retinoic acid|dopamine metabolic process|response to amino acid|peristalsis|response to food|long term synaptic depression|long-term synaptic potentiation|grooming behavior|negative regulation of cell migration|operant conditioning|negative regulation of circadian sleep/wake cycle, sleep|phospholipase C-activating dopamine receptor signaling pathway|mating behavior	nonmotile primary cilium|nucleus|plasma membrane|axon terminus|endoplasmic reticulum membrane|caveola|neuronal cell body|dendritic shaft|dendritic spine head|dendritic spine neck|cytosol|ciliary membrane|integral component of plasma membrane	0.5185	NA
P21918	D(1B) dopamine receptor	DRD5_HUMAN	35	DRD5	1816	NA	hsa04020|hsa04024|hsa04080|hsa04728	Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Dopaminergic synapse	dopamine binding|dopamine neurotransmitter receptor activity|dopamine neurotransmitter receptor activity, coupled via Gs|G-protein coupled amine receptor activity	cellular response to catecholamine stimulus|sensitization|learning|transmission of nerve impulse|synaptic transmission, dopaminergic|long term synaptic depression|synaptic transmission|negative regulation of blood pressure|reactive oxygen species metabolic process|negative regulation of NAD(P)H oxidase activity|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|activation of adenylate cyclase activity|phospholipase C-activating dopamine receptor signaling pathway|wound healing|adenylate cyclase-activating dopamine receptor signaling pathway|positive regulation of adenylate cyclase activity|sensory perception of chemical stimulus|adenylate cyclase-activating G-protein coupled receptor signaling pathway|regulation of female receptivity|response to amphetamine|associative learning|regulation of systemic arterial blood pressure by vasopressin|positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|cellular calcium ion homeostasis|response to cocaine	plasma membrane|ciliary membrane|nonmotile primary cilium|integral component of plasma membrane|brush border membrane	0.5089	NA
P14416	D(2) dopamine receptor	DRD2_HUMAN	111	DRD2	1813	1I15;5AER	hsa04015|hsa04024|hsa04080|hsa04540|hsa04728|hsa05012|hsa05030|hsa05034	Rap1 signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Dopaminergic synapse|Parkinson disease|Cocaine addiction|Alcoholism	drug binding|dopamine binding|identical protein binding|dopamine neurotransmitter receptor activity, coupled via Gi/Go|potassium channel regulator activity	adenohypophysis development|negative regulation of dopamine receptor signaling pathway|phospholipase C-activating dopamine receptor signaling pathway|regulation of synaptic transmission, GABAergic|positive regulation of glial cell-derived neurotrophic factor secretion|G-protein coupled receptor internalization|response to nicotine|arachidonic acid secretion|positive regulation of G-protein coupled receptor protein signaling pathway|prepulse inhibition|regulation of locomotion involved in locomotory behavior|negative regulation of dopamine secretion|response to cocaine|response to morphine|neurological system process involved in regulation of systemic arterial blood pressure|regulation of long-term neuronal synaptic plasticity|negative regulation of insulin secretion|behavioral response to ethanol|sensory perception of smell|response to toxic substance|response to drug|synaptic transmission, dopaminergic|protein localization|auditory behavior|regulation of synapse structural plasticity|response to inactivity|negative regulation of protein secretion|Wnt signaling pathway|negative regulation of adenylate cyclase activity|positive regulation of multicellular organism growth|regulation of phosphoprotein phosphatase activity|intracellular signal transduction|negative regulation of synaptic transmission, glutamatergic|negative regulation of voltage-gated calcium channel activity|branching morphogenesis of a nerve|axonogenesis|response to light stimulus|positive regulation of renal sodium excretion|regulation of cAMP metabolic process|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|temperature homeostasis|positive regulation of dopamine uptake involved in synaptic transmission|orbitofrontal cortex development|behavioral response to cocaine|negative regulation of protein kinase B signaling|response to histamine|cerebral cortex GABAergic interneuron migration|dopamine metabolic process|regulation of sodium ion transport|regulation of dopamine secretion|regulation of heart rate|negative regulation of cytosolic calcium ion concentration|pigmentation|positive regulation of cytokinesis|positive regulation of growth hormone secretion|grooming behavior|adult walking behavior|circadian regulation of gene expression|phosphatidylinositol metabolic process|synapse assembly|peristalsis|feeding behavior|positive regulation of long-term synaptic potentiation|locomotory behavior|long-term memory|positive regulation of neuroblast proliferation|associative learning|negative regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|neuron-neuron synaptic transmission|regulation of potassium ion transport|negative regulation of circadian sleep/wake cycle, sleep|response to amphetamine|visual learning|cellular calcium ion homeostasis|positive regulation of urine volume|positive regulation of transcription from RNA polymerase II promoter|response to axon injury|negative regulation of innate immune response|release of sequestered calcium ion into cytosol|regulation of dopamine uptake involved in synaptic transmission|striatum development|response to iron ion|negative regulation of blood pressure|positive regulation of receptor internalization|response to hypoxia|negative regulation of cell migration|adenylate cyclase-inhibiting dopamine receptor signaling pathway|activation of protein kinase activity	postsynaptic density|axon|axon terminus|perikaryon|intracellular|dendrite|dendritic spine|endocytic vesicle|plasma membrane|sperm flagellum|synaptic vesicle membrane|acrosomal vesicle|ciliary membrane|cytosol|lateral plasma membrane|nonmotile primary cilium|integral component of plasma membrane	0.5088	NA
P07550	Beta-2 adrenergic receptor	ADRB2_HUMAN	81	ADRB2	154	1GQ4;2R4R;2R4S;2RH1;3D4S;3KJ6;3NY8;3NY9;3NYA;3P0G;3PDS;3SN6;4GBR;4LDE;4LDL;4LDO;4QKX	hsa04020|hsa04022|hsa04024|hsa04080|hsa04261|hsa04923|hsa04924|hsa04970	Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion	drug binding|potassium channel regulator activity|dopamine binding|beta2-adrenergic receptor activity|protein homodimerization activity|epinephrine binding|norepinephrine binding	negative regulation of ossification|synaptic transmission, glutamatergic|estrous cycle|positive regulation of protein ubiquitination|activation of adenylate cyclase activity|adenylate cyclase-activating adrenergic receptor signaling pathway|negative regulation of smooth muscle contraction|female pregnancy|activation of transmembrane receptor protein tyrosine kinase activity|positive regulation of transcription from RNA polymerase II promoter|brown fat cell differentiation|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|response to testosterone|wound healing|diet induced thermogenesis|positive regulation of autophagosome maturation|associative learning|excitatory postsynaptic potential|bone resorption|cell surface receptor signaling pathway|heat generation|positive regulation of lipophagy|positive regulation of potassium ion transport|diaphragm contraction|positive regulation of cell proliferation|negative regulation of multicellular organism growth|positive regulation of skeletal muscle tissue growth|positive regulation of sodium ion transport|regulation of sensory perception of pain|negative regulation of angiogenesis|response to estrogen|response to cold|positive regulation of the force of heart contraction by epinephrine|cellular response to hypoxia|cell-cell signaling|positive regulation of MAPK cascade|response to dexamethasone|vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure|response to monoamine|positive regulation of bone mineralization|negative regulation of platelet aggregation|negative regulation of inflammatory response|mitophagy in response to mitochondrial depolarization|aging|positive regulation of apoptotic process|liver regeneration|positive regulation of vasodilation|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|endosome to lysosome transport|regulation of calcium ion transport|response to progesterone|negative regulation of urine volume|receptor-mediated endocytosis|positive regulation of ATPase activity	neuronal cell body membrane|nucleus|dendritic spine|plasma membrane|receptor complex|sarcolemma|lysosome|endosome|axon|early endosome|apical plasma membrane|integral component of plasma membrane	0.4505	NA
P28566	5-hydroxytryptamine receptor 1E	5HT1E_HUMAN	15	HTR1E	3354	NA	hsa04024|hsa04080|hsa04726|hsa04742	cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction	G-protein coupled receptor activity|serotonin receptor activity|serotonin binding	synaptic transmission|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|serotonin receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of cAMP metabolic process	plasma membrane|integral component of plasma membrane	0.4472	NA
P08588	Beta-1 adrenergic receptor	ADRB1_HUMAN	74	ADRB1	153	2LSQ	hsa04020|hsa04022|hsa04024|hsa04080|hsa04261|hsa04540|hsa04923|hsa04924|hsa04970|hsa05414	Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Gap junction|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion|Dilated cardiomyopathy (DCM)	receptor signaling protein activity|beta-adrenergic receptor activity|alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|epinephrine binding|norepinephrine binding|Ras guanyl-nucleotide exchange factor activity|protein heterodimerization activity|PDZ domain binding	diet induced thermogenesis|positive regulation of cAMP biosynthetic process|fear response|heat generation|temperature homeostasis|negative regulation of multicellular organism growth|positive regulation of cAMP-mediated signaling|positive regulation of heart rate by epinephrine-norepinephrine|cell-cell signaling|positive regulation of the force of heart contraction by epinephrine-norepinephrine|response to cold|activation of adenylate cyclase activity|vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure|intracellular signal transduction|adenylate cyclase-activating adrenergic receptor signaling pathway|brown fat cell differentiation|positive regulation of GTPase activity	plasma membrane|early endosome|integral component of plasma membrane	0.4418	NA