Rank	Pathway_ID	Pathway_Name	Total_Gene_Number	Pathway_Class_1st	Pathway_Class_2nd	Gene_Names	Gene_IDs	Num_Targets	P_value_target	P_value_drug
1	hsa04726	Serotonergic synapse	115	Organismal Systems	Nervous system	HTR2A;HTR1D;HTR1B;HTR1A;HTR1E;HTR2C;HTR6;HTR2B;HTR7	3356;3352;3351;3350;3354;3358;3362;3357;3363	9	8.258633125271494e-11	0.1423128261138287
2	hsa04024	cAMP signaling pathway	198	Environmental Information Processing	Signal transduction	HTR1E;HTR1B;DRD5;HTR1A;DRD2;ADRB1;DRD1;HTR1D;HTR6;ADRB2	3354;3351;1816;3350;1813;153;1812;3352;3362;154	10	1.602546556913423e-10	0.17783036039395483
3	hsa04540	Gap junction	88	Cellular Processes	Cellular community - eukaryotes	HTR2C;DRD2;ADRB1;DRD1;HTR2A;HTR2B	3358;1813;153;1812;3356;3357	6	4.07486685583639e-07	0.12862516684914244
4	hsa04728	Dopaminergic synapse	131	Organismal Systems	Nervous system	DRD1;DRD3;DRD5;DRD4;DRD2	1812;1814;1816;1815;1813	5	7.712850680852856e-05	0.12501950179462767
5	hsa04742	Taste transduction	83	Organismal Systems	Sensory system	HTR1B;HTR1A;HTR1D;HTR1E	3351;3350;3352;3354	4	0.00019187399382994798	0.16527120495136888
6	hsa04750	Inflammatory mediator regulation of TRP channels	99	Organismal Systems	Sensory system	HRH1;HTR2A;HTR2B;HTR2C	3269;3356;3357;3358	4	0.00031864667014174576	0.1334348214585668
7	hsa05030	Cocaine addiction	49	Human Diseases	Substance dependence	DRD1;DRD2	1812;1813	2	0.016977834854115994	0.17972853502576674
8	hsa04923	Regulation of lipolysis in adipocytes	54	Organismal Systems	Endocrine system	ADRB1;ADRB2	153;154	2	0.017932814852665638	0.23239898070689283
9	hsa04924	Renin secretion	65	Organismal Systems	Endocrine system	ADRB1;ADRB2	153;154	2	0.02276580720631349	0.2839461230441664
10	hsa05012	Parkinson disease	142	Human Diseases	Neurodegenerative diseases	DRD1;DRD2	1812;1813	2	0.08724700702789041	0.3679165149873103
11	hsa05034	Alcoholism	180	Human Diseases	Substance dependence	DRD1;DRD2	1812;1813	2	0.12020101948542962	0.1438660356757919
12	hsa05031	Amphetamine addiction	68	Human Diseases	Substance dependence	DRD1	1812	1	0.22311943831771175	0.20046110908936435
13	hsa05032	Morphine addiction	91	Human Diseases	Substance dependence	DRD1	1812	1	0.2487415841676759	0.1559681268459737
14	hsa05414	Dilated cardiomyopathy (DCM)	90	Human Diseases	Cardiovascular diseases	ADRB1	153	1	0.2487415841676759	0.5314888969801379
15	hsa04015	Rap1 signaling pathway	206	Environmental Information Processing	Signal transduction	DRD2	1813	1	0.45738293701722094	0.12501950179462767
16	hsa04014	Ras signaling pathway	232	Environmental Information Processing	Signal transduction	HTR7	3363	1	0.4683756756068361	0.12862516684914244