Rank	Pathway_ID	Pathway_Name	Total_Gene_Number	Pathway_Class_1st	Pathway_Class_2nd	Gene_Names	Gene_IDs	Num_Targets	P_value_target	P_value_drug
1	hsa04020	Calcium signaling pathway	183	Environmental Information Processing	Signal transduction	HTR2C;ADRA1A;DRD5;ADRA1B;ADRB3;DRD1;ADRA1D;HTR2A;HTR6;HRH2;HRH1;ADRB2;HTR2B;HTR7	3358;148;1816;147;155;1812;146;3356;3362;3274;3269;154;3357;3363	14	1.2785865933212837e-17	0.18147069530451468
2	hsa04726	Serotonergic synapse	115	Organismal Systems	Nervous system	HTR1D;HTR1B;HTR1A;HTR2C;HTR2A;HTR6;HTR2B;HTR7	3352;3351;3350;3358;3356;3362;3357;3363	8	2.933260667561252e-09	0.1467601019298858
3	hsa04024	cAMP signaling pathway	198	Environmental Information Processing	Signal transduction	HTR1B;DRD2;DRD5;HTR1A;DRD1;HTR1D;HTR6;ADRB2	3351;1813;1816;3350;1812;3352;3362;154	8	1.487832240582898e-07	0.18147069530451468
4	hsa04540	Gap junction	88	Cellular Processes	Cellular community - eukaryotes	DRD1;DRD2;HTR2A;HTR2B;HTR2C	1812;1813;3356;3357;3358	5	1.3426719885529734e-05	0.12978864643823612
5	hsa04970	Salivary secretion	90	Organismal Systems	Digestive system	ADRA1A;ADRB2;ADRA1B;ADRB3;ADRA1D	148;154;147;155;146	5	1.3426719885529734e-05	0.16235893702269033
6	hsa04750	Inflammatory mediator regulation of TRP channels	99	Organismal Systems	Sensory system	HRH1;HTR2A;HTR2B;HTR2C	3269;3356;3357;3358	4	0.00043813917144490047	0.13454677830405484
7	hsa04728	Dopaminergic synapse	131	Organismal Systems	Nervous system	DRD1;DRD5;DRD4;DRD2	1812;1816;1815;1813	4	0.0011061892322251478	0.12666449523929382
8	hsa04261	Adrenergic signaling in cardiomyocytes	144	Organismal Systems	Circulatory system	ADRA1A;ADRB2;ADRA1B;ADRA1D	148;154;147;146	4	0.0013876934166902608	0.12947457832824374
9	hsa04742	Taste transduction	83	Organismal Systems	Sensory system	HTR1B;HTR1A;HTR1D	3351;3350;3352	3	0.0032160301093609326	0.17619220968392774
10	hsa04270	Vascular smooth muscle contraction	121	Organismal Systems	Circulatory system	ADRA1A;ADRA1B;ADRA1D	148;147;146	3	0.008502103112809967	0.1514986045387548
11	hsa05030	Cocaine addiction	49	Human Diseases	Substance dependence	DRD1;DRD2	1812;1813	2	0.014855605497351494	0.192209683291445
12	hsa04923	Regulation of lipolysis in adipocytes	54	Organismal Systems	Endocrine system	ADRB2;ADRB3	154;155	2	0.0164384136149435	0.22824899890855546
13	hsa04924	Renin secretion	65	Organismal Systems	Endocrine system	ADRB2;ADRB3	154;155	2	0.021671297244471494	0.26028394612381917
14	hsa05012	Parkinson disease	142	Human Diseases	Neurodegenerative diseases	DRD1;DRD2	1812;1813	2	0.08568902475953523	0.3653986166738448
15	hsa05034	Alcoholism	180	Human Diseases	Substance dependence	DRD1;DRD2	1812;1813	2	0.1212026946478082	0.14129699932443848
16	hsa05031	Amphetamine addiction	68	Human Diseases	Substance dependence	DRD1	1812	1	0.23009192076514023	0.206725518748407
17	hsa04971	Gastric acid secretion	75	Organismal Systems	Digestive system	HRH2	3274	1	0.23678154323331022	0.6727338915202006
18	hsa05032	Morphine addiction	91	Human Diseases	Substance dependence	DRD1	1812	1	0.26601530529043116	0.148469659209148
19	hsa04152	AMPK signaling pathway	120	Environmental Information Processing	Signal transduction	ADRA1A	148	1	0.320706417647473	0.30353112486453104
20	hsa04714	Thermogenesis	229	Organismal Systems	Environmental adaptation	ADRB3	155	1	0.4683756756068361	0.4871981555651264
21	hsa04014	Ras signaling pathway	232	Environmental Information Processing	Signal transduction	HTR7	3363	1	0.4683756756068361	0.13264470331317813
22	hsa04015	Rap1 signaling pathway	206	Environmental Information Processing	Signal transduction	DRD2	1813	1	0.47167615379900907	0.12666449523929382