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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00172
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00172 L-Proline Thumb


22 known interactions (targets) of input drug (DB00172): L-Proline
No. Gene UniProt ID Protein Name Pathway PDB
1 PROSC O94903 Proline synthase co-transcribed bacterial homolog protein NA NA
2 PPIG Q13427 Peptidyl-prolyl cis-trans isomerase G NA 2GW2; 2WFI; 2WFJ
3 P3H3 Q8IVL6 Prolyl 3-hydroxylase 3 NA NA
4 L3HYPDH Q96EM0 Trans-3-hydroxy-L-proline dehydratase hsa00330 NA
5 PYCR1 P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial hsa00330; hsa01100; hsa01230 2GER; 2GR9; 2GRA; 2IZZ
6 SLC6A14 Q9UN76 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) NA NA
7 PRODH O43272 Proline dehydrogenase 1, mitochondrial hsa00330; hsa01100 NA
8 PYCRL Q53H96 Pyrroline-5-carboxylate reductase 3 hsa00330; hsa01100; hsa01230 NA
9 PPIC P45877 Peptidyl-prolyl cis-trans isomerase C NA 2ESL
10 PARS2 Q7L3T8 Probable proline--tRNA ligase, mitochondrial hsa00970 NA
11 PYCR2 Q96C36 Pyrroline-5-carboxylate reductase 2 hsa00330; hsa01100; hsa01230 NA
12 P4HA2 O15460 Prolyl 4-hydroxylase subunit alpha-2 hsa00330; hsa01100 NA
13 PPIB P23284 Peptidyl-prolyl cis-trans isomerase B NA 1CYN; 3ICH; 3ICI
14 PPIA P62937 Peptidyl-prolyl cis-trans isomerase A hsa04217
15 P3H2 Q8IVL5 Prolyl 3-hydroxylase 2 NA NA
16 SLC6A7 Q99884 Sodium-dependent proline transporter NA NA
17 PPIF P30405 Peptidyl-prolyl cis-trans isomerase F, mitochondrial hsa04020; hsa04022; hsa05012; hsa05016; hsa05145
18 P5CR2 Q4W8W1 Pyrroline-5-carboxylate reductase NA NA
19 EPRS P07814 Bifunctional glutamate/proline--tRNA ligase hsa00860; hsa00970; hsa01100 1FYJ; 4HVC; 4K86; 4K87; 4K88; 5A34; 5BMU
20 P4HA1 P13674 Prolyl 4-hydroxylase subunit alpha-1 hsa00330; hsa01100 1TJC; 2V5F; 2YQ8; 4BT8; 4BT9; 4BTA; 4BTB
21 PPIH O43447 Peptidyl-prolyl cis-trans isomerase H hsa03040 1MZW; 1QOI
22 P3H1 Q32P28 Prolyl 3-hydroxylase 1 NA NA


20 predicted interactions (targets) of input drug (DB00172): L-Proline
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 MTOR P42345 Serine/threonine-protein kinase mTOR hsa01521; hsa01522; hsa04012; hsa04066; hsa04072; hsa04136; hsa04140; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04218; hsa04371; hsa04630; hsa04659; hsa04714; hsa04910; hsa04919; hsa04920; hsa04930; hsa04931; hsa05163; hsa05165; hsa05167; hsa05170; hsa05200; hsa05205; hsa05206; hsa05210; hsa05212; hsa05214; hsa05215; hsa05221; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231 1AUE; 1FAP; 1NSG; 2FAP; 2GAQ; 2NPU; 2RSE; 3FAP; 4DRH; 4DRI; 4DRJ; 4FAP; 4JSN; 4JSP; 4JSV; 4JSX; 4JT5; 4JT6 33.4%
2 ADORA2A P29274 Adenosine receptor A2a hsa04015; hsa04020; hsa04024; hsa04080; hsa04270; hsa05012; hsa05034 1MMH; 1UPE; 2YDO; 2YDV; 3EML; 3PWH; 3QAK; 3REY; 3RFM; 3UZA; 3UZC; 3VG9; 3VGA; 4EIY; 4UG2; 4UHR 33.0%
3 PPP3R2 Q96LZ3 Calcineurin subunit B type 2 hsa04010; hsa04020; hsa04022; hsa04114; hsa04218; hsa04310; hsa04360; hsa04370; hsa04380; hsa04625; hsa04650; hsa04658; hsa04659; hsa04660; hsa04662; hsa04720; hsa04724; hsa04921; hsa04922; hsa04924; hsa05010; hsa05014; hsa05031; hsa05152; hsa05163; hsa05166; hsa05167; hsa05170 NA 31.4%
4 PLOD1 Q02809 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 hsa00310 NA 31.2%
5 TOP2A P11388 DNA topoisomerase 2-alpha hsa01524 1LWZ; 1ZXM; 1ZXN; 4FM9; 4R1F 30.0%
6 NOS2 P35228 Nitric oxide synthase, inducible hsa00220; hsa00330; hsa01100; hsa04020; hsa04066; hsa04146; hsa04371; hsa04926; hsa05132; hsa05133; hsa05140; hsa05142; hsa05145; hsa05146; hsa05152; hsa05200; hsa05222 1NSI; 2LL6; 2NSI; 3E7G; 3EJ8; 3HR4; 4CX7; 4NOS 29.2%
7 LYZ P61626 Lysozyme C hsa04970
133L; 134L; 1B5U; 1B5V; 1B5W; 1B5X; 1B5Y; 1B5Z; 1B7L; 1B7M; 1B7N; 1B7O; 1B7P; 1B7Q; 1B7R; 1B7S; 1BB3; 1BB4; 1BB5; 1C43; 1C45; 1C46; 1C7P; 1CJ6; 1CJ7; 1CJ8; 1CJ9; 1CKC; 1CKD; 1CKF; 1CKG; 1CKH; 1D6P; 1D6Q; 1DI3; 1DI4; 1DI5; 1EQ4; 1EQ5; 1EQE; 1GAY; 1GAZ; 1GB0; 1GB2; 1GB3; 1GB5; 1GB6; 1GB7; 1GB8; 1GB9; 1GBO; 1GBW; 1GBX; 1GBY; 1GBZ; 1GDW; 1GDX; 1GE0; 1GE1; 1GE2; 1GE3; 1GE4; 1GEV; 1GEZ; 1GF0; 1GF3; 1GF4; 1GF5; 1GF6; 1GF7; 1GF8; 1GF9; 1GFA; 1GFE; 1GFG; 1GFH; 1GFJ; 1GFK; 1GFR; 1GFT; 1GFU; 1GFV; 1HNL; 1I1Z; 1I20; 1I22; 1INU; 1IOC; 1IP1; 1IP2; 1IP3; 1IP4; 1IP5; 1IP6; 1IP7; 1IWT; 1IWU; 1IWV; 1IWW; 1IWX; 1IWY; 1IWZ; 1IX0; 1IY3; 1IY4; 1JKA; 1JKB; 1JKC; 1JKD; 1JSF; 1JWR; 1LAA; 1LHH; 1LHI; 1LHJ; 1LHK; 1LHL; 1LHM; 1LMT; 1LOZ; 1LYY; 1LZ1; 1LZ4; 1LZ5; 1LZ6; 1LZR; 1LZS; 1OP9; 1OUA; 1OUB; 1OUC; 1OUD; 1OUE; 1OUF; 1OUG; 1OUH; 1OUI; 1OUJ; 1QSW; 1RE2; 1REM; 1REX; 1REY; 1REZ; 1TAY; 1TBY; 1TCY; 1TDY; 1UBZ; 1W08; 1WQM; 1WQN; 1WQO; 1WQP; 1WQQ; 1WQR; 1YAM; 1YAN; 1YAO; 1YAP; 1YAQ; 207L; 208L; 2BQA; 2BQB; 2BQC; 2BQD; 2BQE; 2BQF; 2BQG; 2BQH; 2BQI; 2BQJ; 2BQK; 2BQL; 2BQM; 2BQN; 2BQO; 2HEA; 2HEB; 2HEC; 2HED; 2HEE; 2HEF; 2LHM; 2MEA; 2MEB; 2MEC; 2MED; 2MEE; 2MEF; 2MEG; 2MEH; 2MEI; 2NWD; 2ZIJ; 2ZIK; 2ZIL; 2ZWB; 3EBA; 3FE0; 3LHM; 3LN2; 4I0C; 4ML7; 4R0P
 28.5%
8 BBOX1 O75936 Gamma-butyrobetaine dioxygenase hsa00310 3MS5; 3N6W; 3O2G; 4BG1; 4BGK; 4BGM; 4BHF; 4BHG; 4BHI; 4C5W; 4C8R; 4CWD 28.4%
9 DHFR P00374 Dihydrofolate reductase hsa00670; hsa00790; hsa01100; hsa01523 28.2%
10 FCGR3A P08637 Low affinity immunoglobulin gamma Fc region receptor III-A hsa04145; hsa04380; hsa04650; hsa04666; hsa05140; hsa05150; hsa05152; hsa05322 3AY4; 3SGJ; 3SGK; 3WN5; 5BW7 27.9%
11 ADH1C P00326 Alcohol dehydrogenase 1C hsa00010; hsa00071; hsa00350; hsa00830; hsa00980; hsa00982; hsa01100; hsa05204 1DDA; 1HT0; 1U3W 27.4%
12 FCGR2A P12318 Low affinity immunoglobulin gamma Fc region receptor II-a hsa04145; hsa04380; hsa04611; hsa04666; hsa05140; hsa05150; hsa05152; hsa05322 1FCG; 1H9V; 3D5O; 3RY4; 3RY5; 3RY6 26.4%
13 SUCNR1 Q9BXA5 Succinate receptor 1 hsa04024 NA 26.2%
14 PLOD3 O60568 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 hsa00310; hsa00514 NA 26.1%
15 OXCT1 P55809 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial hsa00072; hsa00280; hsa00650 3DLX 26.0%
16 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 hsa04520; hsa04910; hsa04931 25.9%
17 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 hsa04010; hsa04014; hsa04015; hsa04024; hsa04062; hsa04071; hsa04145; hsa04151; hsa04310; hsa04360; hsa04370; hsa04380; hsa04510; hsa04520; hsa04530; hsa04620; hsa04650; hsa04662; hsa04664; hsa04666; hsa04670; hsa04722; hsa04810; hsa04932; hsa04933; hsa04972; hsa05014; hsa05100; hsa05120; hsa05131; hsa05132; hsa05163; hsa05167; hsa05170; hsa05200; hsa05203; hsa05205; hsa05210; hsa05211; hsa05212; hsa05231; hsa05416; hsa05418 25.5%
18 AKR1C3 P42330 Aldo-keto reductase family 1 member C3 hsa00140; hsa00590; hsa00790; hsa01100; hsa04913 25.5%
19 TH P07101 Tyrosine 3-monooxygenase hsa00350; hsa00790; hsa01100; hsa04728; hsa04917; hsa05012; hsa05030; hsa05031; hsa05034 2XSN; 4J6S 25.3%
20 CDK2 P24941 Cyclin-dependent kinase 2 hsa04068; hsa04110; hsa04114; hsa04115; hsa04151; hsa04218; hsa04914; hsa04934; hsa05161; hsa05162; hsa05165; hsa05168; hsa05169; hsa05200; hsa05203; hsa05215; hsa05222; hsa05226
1AQ1; 1B38; 1B39; 1BUH; 1CKP; 1DI8; 1DM2; 1E1V; 1E1X; 1E9H; 1F5Q; 1FIN; 1FQ1; 1FVT; 1FVV; 1G5S; 1GIH; 1GII; 1GIJ; 1GY3; 1GZ8; 1H00; 1H01; 1H07; 1H08; 1H0V; 1H0W; 1H1P; 1H1Q; 1H1R; 1H1S; 1H24; 1H25; 1H26; 1H27; 1H28; 1HCK; 1HCL; 1JST; 1JSU; 1JSV; 1JVP; 1KE5; 1KE6; 1KE7; 1KE8; 1KE9; 1OGU; 1OI9; 1OIQ; 1OIR; 1OIT; 1OIU; 1OIY; 1OKV; 1OKW; 1OL1; 1OL2; 1P2A; 1P5E; 1PF8; 1PKD; 1PW2; 1PXI; 1PXJ; 1PXK; 1PXL; 1PXM; 1PXN; 1PXO; 1PXP; 1PYE; 1QMZ; 1R78; 1URC; 1URW; 1V1K; 1VYW; 1VYZ; 1W0X; 1W8C; 1W98; 1WCC; 1Y8Y; 1Y91; 1YKR; 2A0C; 2A4L; 2B52; 2B53; 2B54; 2B55; 2BHE; 2BHH; 2BKZ; 2BPM; 2BTR; 2BTS; 2C4G; 2C5N; 2C5O; 2C5V; 2C5X; 2C5Y; 2C68; 2C69; 2C6I; 2C6K; 2C6L; 2C6M; 2C6O; 2C6T; 2CCH; 2CCI; 2CJM; 2CLX; 2DS1; 2DUV; 2EXM; 2FVD; 2G9X; 2HIC; 2I40; 2IW6; 2IW8; 2IW9; 2J9M; 2JGZ; 2R3F; 2R3G; 2R3H; 2R3I; 2R3J; 2R3K; 2R3L; 2R3M; 2R3N; 2R3O; 2R3P; 2R3Q; 2R3R; 2R64; 2UUE; 2UZB; 2UZD; 2UZE; 2UZL; 2UZN; 2UZO; 2V0D; 2V22; 2VTA; 2VTH; 2VTI; 2VTJ; 2VTL; 2VTM; 2VTN; 2VTO; 2VTP; 2VTQ; 2VTR; 2VTS; 2VTT; 2VU3; 2VV9; 2W05; 2W06; 2W17; 2W1H; 2WEV; 2WFY; 2WHB; 2WIH; 2WIP; 2WMA; 2WMB; 2WPA; 2WXV; 2X1N; 2XMY; 2XNB; 3BHT; 3BHU; 3BHV; 3DDP; 3DDQ; 3DOG; 3EID; 3EJ1; 3EOC; 3EZR; 3EZV; 3F5X; 3FZ1; 3IG7; 3IGG; 3LE6; 3LFN; 3LFQ; 3LFS; 3MY5; 3NS9; 3PJ8; 3PXF; 3PXQ; 3PXR; 3PXY; 3PXZ; 3PY0; 3PY1; 3QHR; 3QHW; 3QL8; 3QQF; 3QQG; 3QQH; 3QQJ; 3QQK; 3QQL; 3QRT; 3QRU; 3QTQ; 3QTR; 3QTS; 3QTU; 3QTW; 3QTX; 3QTZ; 3QU0; 3QWJ; 3QWK; 3QX2; 3QX4; 3QXO; 3QXP; 3QZF; 3QZG; 3QZH; 3QZI; 3R1Q; 3R1S; 3R1Y; 3R28; 3R6X; 3R71; 3R73; 3R7E; 3R7I; 3R7U; 3R7V; 3R7Y; 3R83; 3R8L; 3R8M; 3R8P; 3R8U; 3R8V; 3R8Z; 3R9D; 3R9H; 3R9N; 3R9O; 3RAH; 3RAI; 3RAK; 3RAL; 3RJC; 3RK5; 3RK7; 3RK9; 3RKB; 3RM6; 3RM7; 3RMF; 3RNI; 3ROY; 3RPO; 3RPR; 3RPV; 3RPY; 3RZB; 3S00; 3S0O; 3S1H; 3S2P; 3SQQ; 3SW4; 3SW7; 3TI1; 3TIY; 3TIZ; 3TNW; 3ULI; 3UNJ; 3UNK; 3WBL; 4ACM; 4BCK; 4BCM; 4BCN; 4BCO; 4BCP; 4BCQ; 4BGH; 4BZD; 4CFM; 4CFN; 4CFU; 4CFV; 4CFW; 4CFX; 4D1X; 4D1Z; 4EK3; 4EK4; 4EK5; 4EK6; 4EK8; 4EOI; 4EOJ; 4EOK; 4EOL; 4EOM; 4EON; 4EOO; 4EOP; 4EOQ; 4EOR; 4EOS; 4ERW; 4EZ3; 4EZ7; 4FKG; 4FKI; 4FKJ; 4FKL; 4FKO; 4FKP; 4FKQ; 4FKR; 4FKS; 4FKT; 4FKU; 4FKV; 4FKW; 4FX3; 4GCJ; 4I3Z; 4II5; 4KD1; 4LYN; 4NJ3; 4RJ3; 5A14; 5CYI; 5D1J
 24.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.