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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB06245
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational BiotechDrug DB06245 Lanoteplase Thumb


17 known interactions (targets) of input drug (DB06245): Lanoteplase
No. Gene UniProt ID Protein Name Pathway PDB
1 LAMB1 P07942 Laminin subunit beta-1 hsa04151; hsa04510; hsa04512; hsa05145; hsa05146; hsa05165; hsa05200; hsa05222 NA
2 PLAUR Q03405 Urokinase plasminogen activator surface receptor hsa04610; hsa05205 1YWH; 2FD6; 2I9B; 3BT1; 3BT2; 3U73; 3U74; 4K24; 4QTI
3 CLEC3B P05452 Tetranectin NA 1HTN; 1RJH; 1TN3; 3L9J
4 LAMA5 O15230 Laminin subunit alpha-5 hsa01100; hsa04151; hsa04510; hsa04512; hsa05145; hsa05146; hsa05165; hsa05200; hsa05222 NA
5 SERPINB2 P05120 Plasminogen activator inhibitor 2 hsa04610 1BY7; 1JRR; 2ARQ; 2ARR
6 CALR P27797 Calreticulin hsa04141; hsa04145; hsa04612; hsa05142; hsa05163; hsa05166; hsa05170 2CLR; 3DOW; 3POS; 3POW
7 KLK1 P06870 Kallikrein-1 hsa04614; hsa04961 1SPJ
8 LAMA1 P25391 Laminin subunit alpha-1 hsa04151; hsa04510; hsa04512; hsa05145; hsa05146; hsa05165; hsa05200; hsa05222 NA
9 FN1 P02751 Fibronectin hsa04151; hsa04510; hsa04512; hsa04810; hsa04933; hsa05100; hsa05146; hsa05165; hsa05200; hsa05205; hsa05222
10 CANX P27824 Calnexin hsa04141; hsa04145; hsa04612; hsa04918; hsa05166 NA
11 FGA P02671 Fibrinogen alpha chain hsa04610; hsa04611
12 F10 P00742 Coagulation factor X hsa04610
1C5M; 1EZQ; 1F0R; 1F0S; 1FAX; 1FJS; 1FXY; 1G2L; 1G2M; 1HCG; 1IOE; 1IQE; 1IQF; 1IQG; 1IQH; 1IQI; 1IQJ; 1IQK; 1IQL; 1IQM; 1IQN; 1KSN; 1LPG; 1LPK; 1LPZ; 1LQD; 1MQ5; 1MQ6; 1MSX; 1NFU; 1NFW; 1NFX; 1NFY; 1NL8; 1P0S; 1V3X; 1WU1; 1XKA; 1XKB; 1Z6E; 2BMG; 2BOH; 2BOK; 2BQ6; 2BQ7; 2BQW; 2CJI; 2D1J; 2EI6; 2EI7; 2EI8; 2FZZ; 2G00; 2GD4; 2H9E; 2J2U; 2J34; 2J38; 2J4I; 2J94; 2J95; 2JKH; 2P16; 2P3F; 2P3T; 2P3U; 2P93; 2P94; 2P95; 2PHB; 2PR3; 2Q1J; 2RA0; 2UWL; 2UWO; 2UWP; 2VH0; 2VH6; 2VVC; 2VVU; 2VVV; 2VWL; 2VWM; 2VWN; 2VWO; 2W26; 2W3I; 2W3K; 2WYG; 2WYJ; 2XBV; 2XBW; 2XBX; 2XBY; 2XC0; 2XC4; 2XC5; 2Y5F; 2Y5G; 2Y5H; 2Y7X; 2Y7Z; 2Y80; 2Y81; 2Y82; 3CEN; 3CS7; 3ENS; 3FFG; 3HPT; 3IIT; 3K9X; 3KL6; 3KQB; 3KQC; 3KQD; 3KQE; 3LIW; 3M36; 3M37; 3Q3K; 3SW2; 3TK5; 3TK6; 4A7I; 4BTI; 4BTT; 4BTU; 4Y6D; 4Y71; 4Y76; 4Y79; 4Y7A; 4Y7B
13 LAMA3 Q16787 Laminin subunit alpha-3 hsa01100; hsa04151; hsa04510; hsa04512; hsa05145; hsa05146; hsa05165; hsa05200; hsa05222 NA
14 ANXA2 P07355 Annexin A2 NA 1W7B; 1XJL; 2HYU; 2HYV; 2HYW; 4DRW; 4FTG; 4HRH
15 LRP1 Q07954 Prolow-density lipoprotein receptor-related protein 1 hsa04979; hsa05010; hsa05144 1CR8; 1D2L; 1J8E; 2FYJ; 2FYL; 2KNX; 2KNY
16 LAMC1 P11047 Laminin subunit gamma-1 hsa04151; hsa04510; hsa04512; hsa05020; hsa05145; hsa05146; hsa05165; hsa05200; hsa05222 NA
17 KRT8 P05787 Keratin, type II cytoskeletal 8 NA NA


20 predicted interactions (targets) of input drug (DB06245): Lanoteplase
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 F9 P00740 Coagulation factor IX hsa04610 54.2%
2 SERPINE1 P05121 Plasminogen activator inhibitor 1 hsa04066; hsa04115; hsa04218; hsa04371; hsa04390; hsa04610; hsa04933; hsa05142 47.0%
3 PLG P00747 Plasminogen hsa04080; hsa04610; hsa05150; hsa05164 43.0%
4 DPP4 P27487 Dipeptidyl peptidase 4 hsa04974 37.1%
5 HSPA5 P11021 78 kDa glucose-regulated protein hsa03060; hsa04141; hsa04612; hsa04918; hsa05020 3IUC; 3LDL; 3LDN; 3LDO; 3LDP 35.4%
6 F8 P00451 Coagulation factor VIII hsa04610 1CFG; 1D7P; 1FAC; 1IQD; 2R7E; 3CDZ; 3HNB; 3HNY; 3HOB; 3J2Q; 3J2S; 4BDV; 4KI5; 4PT6 35.3%
7 TOP2B Q02880 DNA topoisomerase 2-beta hsa01524 3QX3; 4G0U; 4G0V; 4G0W; 4J3N 34.5%
8 F7 P08709 Coagulation factor VII hsa04610 33.6%
9 LMAN1 P49257 Protein ERGIC-53 hsa04141 3A4U; 3LCP; 3WHT; 3WHU; 3WNX; 4GKX; 4GKY 31.4%
10 VWF P04275 von Willebrand factor hsa04151; hsa04510; hsa04512; hsa04610; hsa04611; hsa05165 31.1%
11 ASGR2 P07307 Asialoglycoprotein receptor 2 hsa04918 NA 30.9%
12 PHYH O14832 Phytanoyl-CoA dioxygenase, peroxisomal hsa04146 2A1X 29.9%
13 MCFD2 Q8NI22 Multiple coagulation factor deficiency protein 2 NA 2VRG; 3A4U; 3LCP; 3WHT; 3WHU; 3WNX 29.1%
14 SERPINA5 P05154 Plasma serine protease inhibitor hsa04610 1LQ8; 1PAI; 2HI9; 2OL2; 2PAI; 3DY0 29.0%
15 DNMT1 P26358 DNA (cytosine-5)-methyltransferase 1 hsa00270; hsa01100; hsa05206 3EPZ; 3PTA; 3SWR; 4WXX; 4YOC 27.1%
16 GSK3B P49841 Glycogen synthase kinase-3 beta hsa01521; hsa04012; hsa04062; hsa04110; hsa04150; hsa04151; hsa04310; hsa04340; hsa04360; hsa04390; hsa04510; hsa04550; hsa04657; hsa04660; hsa04662; hsa04722; hsa04728; hsa04910; hsa04916; hsa04917; hsa04919; hsa04931; hsa04932; hsa04934; hsa05010; hsa05160; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05200; hsa05210; hsa05213; hsa05215; hsa05217; hsa05224; hsa05225; hsa05226 26.9%
17 CYCS P99999 Cytochrome c hsa01524; hsa04115; hsa04210; hsa04215; hsa04932; hsa05010; hsa05012; hsa05014; hsa05016; hsa05134; hsa05145; hsa05152; hsa05161; hsa05163; hsa05164; hsa05167; hsa05168; hsa05170; hsa05200; hsa05210; hsa05222; hsa05416 1J3S; 3NWV; 3ZCF; 3ZOO 26.5%
18 FGB P02675 Fibrinogen beta chain hsa04610; hsa04611 26.3%
19 GGCX P38435 Vitamin K-dependent gamma-carboxylase hsa00130 NA 26.1%
20 CPB2 Q96IY4 Carboxypeptidase B2 hsa04610; hsa04972; hsa04974 3D66; 3D67; 3D68; 3LMS; 4P10 25.9%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.