No. |
Gene |
UniProt ID |
Protein Name |
Pathway |
PDB |
1 |
PDE6C |
P51160 |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
hsa00230 |
3JWQ; 3JWR; 5E8F |
2 |
PDE2A |
O00408 |
cGMP-dependent 3',5'-cyclic phosphodiesterase |
hsa00230; hsa04022; hsa04740; hsa04925; hsa05032 |
1Z1L; 3IBJ; 3ITM; 3ITU; 4C1I; 4D08; 4D09; 4HTX; 4HTZ; 4JIB |
3 |
PDE7A |
Q13946 |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
hsa00230; hsa05032 |
1ZKL; 3G3N; 4PM0; 4Y2B |
4 |
PDE3B |
Q13370 |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B |
hsa00230; hsa04022; hsa04024; hsa04371; hsa04910; hsa04914; hsa04922; hsa04923; hsa04924; hsa05032 |
1SO2; 1SOJ |
5 |
PDE1B |
Q01064 |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B |
hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032 |
1LXR; 1TAZ; 4NPV; 4NPW |
6 |
PDE4D |
Q08499 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
hsa00230; hsa04024; hsa04928; hsa05032 |
|
7 |
PDE1A |
P54750 |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032 |
1LXQ |
8 |
PDE6B |
P35913 |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
hsa00230; hsa04744 |
NA |
9 |
PDE11A |
Q9HCR9 |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
hsa00230; hsa04934; hsa05032 |
NA |
10 |
PDE7B |
Q9NP56 |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
hsa00230; hsa05032 |
1LXW |
11 |
PDE4B |
Q07343 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
hsa00230; hsa04024; hsa04928; hsa05032 |
|
12 |
PDE3A |
Q14432 |
cGMP-inhibited 3',5'-cyclic phosphodiesterase A |
hsa00230; hsa04022; hsa04024; hsa04924; hsa05032 |
1LRC |
13 |
PDE9A |
O76083 |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
hsa00230 |
|
14 |
PDE5A |
O76074 |
cGMP-specific 3',5'-cyclic phosphodiesterase |
hsa00230; hsa04022 |
|
15 |
PDE6A |
P16499 |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
hsa00230; hsa04744 |
NA |
16 |
PDE8A |
O60658 |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
hsa00230; hsa04927; hsa04934; hsa05032 |
1LHQ; 1LXX; 3ECM; 3ECN |
17 |
PDE4C |
Q08493 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
hsa00230; hsa04024; hsa04928; hsa05032 |
1LXU; 2QYM |
18 |
PDE10A |
Q9Y233 |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
hsa00230; hsa05032 |
|
19 |
PDE4A |
P27815 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
hsa00230; hsa04024; hsa04928; hsa05032 |
2QYK; 3I8V; 3TVX |
20 |
PDE8B |
O95263 |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
hsa00230; hsa04927; hsa04934; hsa05032 |
NA |
21 |
PDE1C |
Q14123 |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032 |
1LXS |
No. |
Gene |
UniProt ID |
Protein Name |
Pathway |
PDB |
Confidence score |
1 |
ADORA1 |
P30542 |
Adenosine receptor A1 |
hsa04022; hsa04024; hsa04071; hsa04080; hsa04923; hsa04924; hsa05032 |
NA |
66.5%
|
2 |
ITPR1 |
Q14643 |
Inositol 1,4,5-trisphosphate receptor type 1 |
hsa04020; hsa04022; hsa04070; hsa04114; hsa04140; hsa04210; hsa04218; hsa04270; hsa04371; hsa04540; hsa04611; hsa04621; hsa04625; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04728; hsa04730; hsa04750; hsa04912; hsa04915; hsa04918; hsa04921; hsa04922; hsa04924; hsa04925; hsa04927; hsa04928; hsa04934; hsa04970; hsa04971; hsa04972; hsa05010; hsa05016; hsa05163; hsa05167; hsa05170; hsa05205 |
NA |
58.0%
|
3 |
ATM |
Q13315 |
Serine-protein kinase ATM |
hsa01524; hsa03440; hsa04064; hsa04068; hsa04110; hsa04115; hsa04210; hsa04218; hsa05165; hsa05166; hsa05170; hsa05202; hsa05206 |
NA |
55.9%
|
4 |
ADORA2A |
P29274 |
Adenosine receptor A2a |
hsa04015; hsa04020; hsa04024; hsa04080; hsa04270; hsa05012; hsa05034 |
1MMH; 1UPE; 2YDO; 2YDV; 3EML; 3PWH; 3QAK; 3REY; 3RFM; 3UZA; 3UZC; 3VG9; 3VGA; 4EIY; 4UG2; 4UHR |
55.8%
|
5 |
ITPR3 |
Q14573 |
Inositol 1,4,5-trisphosphate receptor type 3 |
hsa04020; hsa04022; hsa04070; hsa04114; hsa04210; hsa04218; hsa04270; hsa04371; hsa04540; hsa04611; hsa04621; hsa04625; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04728; hsa04730; hsa04742; hsa04750; hsa04911; hsa04912; hsa04915; hsa04918; hsa04921; hsa04922; hsa04924; hsa04925; hsa04927; hsa04928; hsa04934; hsa04970; hsa04971; hsa04972; hsa05010; hsa05163; hsa05167; hsa05170; hsa05205 |
NA |
55.4%
|
6 |
PRKDC |
P78527 |
DNA-dependent protein kinase catalytic subunit |
hsa03450; hsa04110 |
NA |
54.5%
|
7 |
ITPR2 |
Q14571 |
Inositol 1,4,5-trisphosphate receptor type 2 |
hsa04020; hsa04022; hsa04070; hsa04114; hsa04210; hsa04218; hsa04270; hsa04371; hsa04540; hsa04611; hsa04621; hsa04625; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04728; hsa04730; hsa04750; hsa04912; hsa04915; hsa04918; hsa04921; hsa04922; hsa04924; hsa04925; hsa04927; hsa04928; hsa04934; hsa04970; hsa04971; hsa04972; hsa05010; hsa05163; hsa05167; hsa05170; hsa05205 |
NA |
52.6%
|
8 |
PIK3CA |
P42336 |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
hsa00562; hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa04960; hsa04973; hsa05100; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05170; hsa05200; hsa05203; hsa05205; hsa05206; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05418 |
2ENQ; 2RD0; 3HHM; 3HIZ; 3ZIM; 4JPS; 4L1B; 4L23; 4L2Y; 4OVU; 4OVV; 4TUU; 4TV3; 4WAF; 4YKN |
52.3%
|
9 |
PIK3CB |
P42338 |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
hsa00562; hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa04960; hsa04973; hsa05100; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05170; hsa05200; hsa05203; hsa05205; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05418 |
NA |
50.1%
|
10 |
RYR1 |
P21817 |
Ryanodine receptor 1 |
hsa04020; hsa04371; hsa04713; hsa04730; hsa04921 |
NA |
48.4%
|
11 |
PIK3CD |
O00329 |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform |
hsa00562; hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa04960; hsa04973; hsa05100; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05170; hsa05200; hsa05203; hsa05205; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05418 |
NA |
44.9%
|
12 |
PDE6G |
P18545 |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
hsa00230; hsa04744 |
3JWR |
31.8%
|
13 |
F10 |
P00742 |
Coagulation factor X |
hsa04610 |
|
28.4%
|
14 |
NQO1 |
P15559 |
NAD(P)H dehydrogenase [quinone] 1 |
hsa00130; hsa05200; hsa05225; hsa05418 |
1D4A; 1DXO; 1GG5; 1H66; 1H69; 1KBO; 1KBQ; 1QBG; 2F1O; 3JSX; 4CET; 4CF6 |
27.9%
|
15 |
ADORA2B |
P29275 |
Adenosine receptor A2b |
hsa04015; hsa04020; hsa04080; hsa04270; hsa05034 |
NA |
27.8%
|
16 |
HSP90B1 |
P14625 |
Endoplasmin |
hsa04141; hsa04151; hsa04657; hsa04915; hsa04918; hsa05200; hsa05215; hsa05418 |
4NH9 |
26.8%
|
17 |
IGHG1 |
P01857 |
Ig gamma-1 chain C region |
NA |
|
26.6%
|
18 |
FBP1 |
P09467 |
Fructose-1,6-bisphosphatase 1 |
hsa00010; hsa00030; hsa00051; hsa01100; hsa01200; hsa04152; hsa04910; hsa04922 |
1FTA; 2FHY; 2FIE; 2FIX; 2JJK; 2VT5; 2WBB; 2WBD; 2Y5K; 2Y5L; 3A29; 3KBZ; 3KC0; 3KC1; 4MJO |
26.5%
|
19 |
PARP1 |
P09874 |
Poly [ADP-ribose] polymerase 1 |
hsa03410; hsa04064; hsa04210; hsa04217 |
|
26.1%
|
20 |
F2 |
P00734 |
Prothrombin |
hsa04080; hsa04610; hsa04810 |
|
25.9%
|