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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB08813
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB08813 Nadroparin Thumb


4 known interactions (targets) of input drug (DB08813): Nadroparin
No. Gene UniProt ID Protein Name Pathway PDB
1 FOS P01100 Proto-oncogene c-Fos hsa01522; hsa04010; hsa04024; hsa04210; hsa04380; hsa04620; hsa04657; hsa04658; hsa04659; hsa04660; hsa04662; hsa04668; hsa04713; hsa04725; hsa04728; hsa04915; hsa04917; hsa04921; hsa04926; hsa04928; hsa05031; hsa05132; hsa05133; hsa05140; hsa05142; hsa05161; hsa05166; hsa05167; hsa05168; hsa05170; hsa05200; hsa05210; hsa05224; hsa05231; hsa05323; hsa05418 1A02; 1FOS; 1S9K
2 MYC P01106 Myc proto-oncogene protein hsa04010; hsa04012; hsa04110; hsa04151; hsa04218; hsa04310; hsa04350; hsa04390; hsa04550; hsa04630; hsa04919; hsa05161; hsa05163; hsa05166; hsa05167; hsa05169; hsa05200; hsa05202; hsa05205; hsa05206; hsa05210; hsa05213; hsa05216; hsa05219; hsa05220; hsa05221; hsa05222; hsa05224; hsa05225; hsa05226; hsa05230 1A93; 1EE4; 1MV0; 1NKP; 2A93; 2OR9; 4Y7R
3 SELP P16109 P-selectin hsa04514; hsa05144; hsa05150 1FSB; 1G1Q; 1G1R; 1G1S; 1HES; 1KJD
4 SERPINC1 P01008 Antithrombin-III hsa04610


20 predicted interactions (targets) of input drug (DB08813): Nadroparin
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 hsa04520; hsa04910; hsa04931 31.1%
2 SERPIND1 P05546 Heparin cofactor 2 hsa04610 1JMJ; 1JMO 29.5%
3 F10 P00742 Coagulation factor X hsa04610
1C5M; 1EZQ; 1F0R; 1F0S; 1FAX; 1FJS; 1FXY; 1G2L; 1G2M; 1HCG; 1IOE; 1IQE; 1IQF; 1IQG; 1IQH; 1IQI; 1IQJ; 1IQK; 1IQL; 1IQM; 1IQN; 1KSN; 1LPG; 1LPK; 1LPZ; 1LQD; 1MQ5; 1MQ6; 1MSX; 1NFU; 1NFW; 1NFX; 1NFY; 1NL8; 1P0S; 1V3X; 1WU1; 1XKA; 1XKB; 1Z6E; 2BMG; 2BOH; 2BOK; 2BQ6; 2BQ7; 2BQW; 2CJI; 2D1J; 2EI6; 2EI7; 2EI8; 2FZZ; 2G00; 2GD4; 2H9E; 2J2U; 2J34; 2J38; 2J4I; 2J94; 2J95; 2JKH; 2P16; 2P3F; 2P3T; 2P3U; 2P93; 2P94; 2P95; 2PHB; 2PR3; 2Q1J; 2RA0; 2UWL; 2UWO; 2UWP; 2VH0; 2VH6; 2VVC; 2VVU; 2VVV; 2VWL; 2VWM; 2VWN; 2VWO; 2W26; 2W3I; 2W3K; 2WYG; 2WYJ; 2XBV; 2XBW; 2XBX; 2XBY; 2XC0; 2XC4; 2XC5; 2Y5F; 2Y5G; 2Y5H; 2Y7X; 2Y7Z; 2Y80; 2Y81; 2Y82; 3CEN; 3CS7; 3ENS; 3FFG; 3HPT; 3IIT; 3K9X; 3KL6; 3KQB; 3KQC; 3KQD; 3KQE; 3LIW; 3M36; 3M37; 3Q3K; 3SW2; 3TK5; 3TK6; 4A7I; 4BTI; 4BTT; 4BTU; 4Y6D; 4Y71; 4Y76; 4Y79; 4Y7A; 4Y7B
 24.2%
4 ACHE P22303 Acetylcholinesterase hsa00564; hsa04725 1B41; 1F8U; 1PUV; 1PUW; 1VZJ; 2CLJ; 2X8B; 3LII; 4BDT; 4EY4; 4EY5; 4EY6; 4EY7; 4EY8; 4M0E; 4M0F; 4PQE 19.6%
5 CALCRL Q16602 Calcitonin gene-related peptide type 1 receptor hsa04080; hsa04270 3AQF; 3N7P; 3N7R; 3N7S; 4RWF; 4RWG 19.3%
6 ALAD P13716 Delta-aminolevulinic acid dehydratase hsa00860; hsa01100 1E51; 1PV8 18.0%
7 TOP2A P11388 DNA topoisomerase 2-alpha hsa01524 1LWZ; 1ZXM; 1ZXN; 4FM9; 4R1F 17.6%
8 HSP90B1 P14625 Endoplasmin hsa04141; hsa04151; hsa04657; hsa04915; hsa04918; hsa05200; hsa05215; hsa05418 4NH9 16.7%
9 DTYMK P23919 Thymidylate kinase hsa00240; hsa01100 16.5%
10 SIGLEC1 Q9BZZ2 Sialoadhesin hsa04514 NA 16.2%
11 CFTR P13569 Cystic fibrosis transmembrane conductance regulator hsa02010; hsa04024; hsa04152; hsa04530; hsa04971; hsa04972; hsa04976; hsa05110 1NBD; 1XMI; 1XMJ; 2BBO; 2BBS; 2BBT; 2LOB; 2PZE; 2PZF; 2PZG; 3GD7; 3ISW 15.9%
12 MAPK14 Q16539 Mitogen-activated protein kinase 14 hsa01522; hsa04010; hsa04015; hsa04068; hsa04071; hsa04218; hsa04261; hsa04370; hsa04380; hsa04550; hsa04611; hsa04620; hsa04621; hsa04622; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04664; hsa04668; hsa04670; hsa04714; hsa04722; hsa04723; hsa04728; hsa04750; hsa04912; hsa04914; hsa04917; hsa04926; hsa04933; hsa05014; hsa05120; hsa05131; hsa05132; hsa05133; hsa05140; hsa05142; hsa05145; hsa05152; hsa05160; hsa05163; hsa05164; hsa05167; hsa05169; hsa05170; hsa05205; hsa05418
1A9U; 1BL6; 1BL7; 1BMK; 1DI9; 1IAN; 1KV1; 1KV2; 1M7Q; 1OUK; 1OUY; 1OVE; 1OZ1; 1R39; 1R3C; 1W7H; 1W82; 1W83; 1W84; 1WBN; 1WBO; 1WBS; 1WBT; 1WBV; 1WBW; 1WFC; 1YQJ; 1ZYJ; 1ZZ2; 1ZZL; 2BAJ; 2BAK; 2BAL; 2BAQ; 2FSL; 2FSM; 2FSO; 2FST; 2GFS; 2I0H; 2LGC; 2NPQ; 2OKR; 2ONL; 2QD9; 2RG5; 2RG6; 2Y8O; 2YIS; 2YIW; 2YIX; 2ZAZ; 2ZB0; 2ZB1; 3BV2; 3BV3; 3BX5; 3C5U; 3CTQ; 3D7Z; 3D83; 3DS6; 3DT1; 3E92; 3E93; 3FC1; 3FI4; 3FKL; 3FKN; 3FKO; 3FL4; 3FLN; 3FLQ; 3FLS; 3FLW; 3FLY; 3FLZ; 3FMH; 3FMJ; 3FMK; 3FML; 3FMM; 3FMN; 3FSF; 3FSK; 3GC7; 3GCP; 3GCQ; 3GCS; 3GCU; 3GCV; 3GFE; 3GI3; 3HA8; 3HEC; 3HEG; 3HL7; 3HLL; 3HP2; 3HP5; 3HRB; 3HUB; 3HUC; 3HV3; 3HV4; 3HV5; 3HV6; 3HV7; 3HVC; 3IPH; 3ITZ; 3IW5; 3IW6; 3IW7; 3IW8; 3K3I; 3K3J; 3KF7; 3KQ7; 3L8S; 3L8X; 3LFA; 3LFB; 3LFC; 3LFD; 3LFE; 3LFF; 3LHJ; 3MGY; 3MH0; 3MH1; 3MH2; 3MH3; 3MPA; 3MPT; 3MVL; 3MVM; 3MW1; 3NEW; 3NNU; 3NNV; 3NNW; 3NNX; 3NWW; 3O8P; 3O8T; 3O8U; 3OBG; 3OBJ; 3OC1; 3OCG; 3OD6; 3ODY; 3ODZ; 3OEF; 3PG3; 3QUD; 3QUE; 3RIN; 3ROC; 3S3I; 3S4Q; 3U8W; 3UVP; 3UVQ; 3UVR; 3ZS5; 3ZSG; 3ZSH; 3ZSI; 3ZYA; 4A9Y; 4AA0; 4AA4; 4AA5; 4AAC; 4DLI; 4DLJ; 4E5A; 4E5B; 4E6A; 4E6C; 4E8A; 4EH2; 4EH3; 4EH4; 4EH5; 4EH6; 4EH7; 4EH8; 4EH9; 4EHV; 4EWQ; 4F9W; 4F9Y; 4FA2; 4GEO; 4KIN; 4KIP; 4KIQ; 4L8M; 4R3C
 15.7%
13 HSP90AB1 P08238 Heat shock protein HSP 90-beta hsa04141; hsa04151; hsa04217; hsa04612; hsa04621; hsa04657; hsa04659; hsa04914; hsa04915; hsa05200; hsa05215; hsa05418 1QZ2; 1UYM; 2L6J; 3FWV; 3NMQ; 3PRY; 3UQ3 15.7%
14 SLC5A2 P31639 Sodium/glucose cotransporter 2 NA NA 15.6%
15 MTOR P42345 Serine/threonine-protein kinase mTOR hsa01521; hsa01522; hsa04012; hsa04066; hsa04072; hsa04136; hsa04140; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04218; hsa04371; hsa04630; hsa04659; hsa04714; hsa04910; hsa04919; hsa04920; hsa04930; hsa04931; hsa05163; hsa05165; hsa05167; hsa05170; hsa05200; hsa05205; hsa05206; hsa05210; hsa05212; hsa05214; hsa05215; hsa05221; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231 1AUE; 1FAP; 1NSG; 2FAP; 2GAQ; 2NPU; 2RSE; 3FAP; 4DRH; 4DRI; 4DRJ; 4FAP; 4JSN; 4JSP; 4JSV; 4JSX; 4JT5; 4JT6 15.4%
16 RAMP2 O60895 Receptor activity-modifying protein 2 hsa04270 2XVT; 3AQE; 3AQF; 4RWF 14.5%
17 PRDX5 P30044 Peroxiredoxin-5, mitochondrial hsa04146 1H4O; 1HD2; 1OC3; 1URM; 2VL2; 2VL3; 2VL9; 3MNG; 4K7I; 4K7N; 4K7O; 4MMM 14.3%
18 SSTR2 P30874 Somatostatin receptor type 2 hsa04024; hsa04080; hsa04971 NA 14.1%
19 ADRA2A P08913 Alpha-2A adrenergic receptor hsa04022; hsa04080 1HLL; 1HO9; 1HOD; 1HOF 14.0%
20 GSTA1 P08263 Glutathione S-transferase A1 hsa00480; hsa00980; hsa00982; hsa00983; hsa01524; hsa05200; hsa05204; hsa05225; hsa05418 14.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.