QuartataWeb 1.0

1 known interactions (targets) of input drug (DB05876): PDE4

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	PDE4A	P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	hsa00230; hsa04024; hsa04928; hsa05032	2QYK; 3I8V; 3TVX

20 predicted interactions (targets) of input drug (DB05876): PDE4

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	PDE4B	Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	hsa00230; hsa04024; hsa04928; hsa05032	1F0J; 1JP1; 1JP2; 1RO6; 1RO9; 1ROR; 1TB5; 1XLX; 1XLZ; 1XM4; 1XM6; 1XMU; 1XMY; 1XN0; 1XOS; 1XOT; 1Y2H; 1Y2J; 2CHM; 2QYL; 3D3P; 3FRG; 3G45; 3GWT; 3HC8; 3HDZ; 3HMV; 3KKT; 3LY2; 3O0J; 3O56; 3O57; 3W5E; 3WD9; 4KP6; 4MYQ; 4NW7; 4WZI; 4X0F	44.3%
2	PDE4D	Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	hsa00230; hsa04024; hsa04928; hsa05032	1E9K; 1MKD; 1OYN; 1PTW; 1Q9M; 1TB7; 1TBB; 1XOM; 1XON; 1XOQ; 1XOR; 1Y2B; 1Y2C; 1Y2D; 1Y2E; 1Y2K; 1ZKN; 2FM0; 2FM5; 2PW3; 2QYN; 3G4G; 3G4I; 3G4K; 3G4L; 3G58; 3IAD; 3IAK; 3K4S; 3SL3; 3SL4; 3SL5; 3SL6; 3SL8; 3V9B; 4OGB; 4W1O; 4WCU	40.6%
3	PDE4C	Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	hsa00230; hsa04024; hsa04928; hsa05032	1LXU; 2QYM	34.0%
4	ADORA1	P30542	Adenosine receptor A1	hsa04022; hsa04024; hsa04071; hsa04080; hsa04923; hsa04924; hsa05032	NA	29.1%
5	ADORA2A	P29274	Adenosine receptor A2a	hsa04015; hsa04020; hsa04024; hsa04080; hsa04270; hsa05012; hsa05034	1MMH; 1UPE; 2YDO; 2YDV; 3EML; 3PWH; 3QAK; 3REY; 3RFM; 3UZA; 3UZC; 3VG9; 3VGA; 4EIY; 4UG2; 4UHR	25.7%
6	PDE3A	Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	hsa00230; hsa04022; hsa04024; hsa04924; hsa05032	1LRC	24.3%
7	ADORA2B	P29275	Adenosine receptor A2b	hsa04015; hsa04020; hsa04080; hsa04270; hsa05034	NA	22.1%
8	PDE10A	Q9Y233	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	hsa00230; hsa05032	1LRB; 2OUN; 2OUP; 2OUQ; 2OUR; 2OUS; 2OUU; 2OUV; 2OUY; 2WEY; 2Y0J; 2ZMF; 3SN7; 3SNI; 3SNL; 3UI7; 3UUO; 3WI2; 3WS8; 3WS9; 3WYK; 3WYL; 3WYM; 4AEL; 4AJD; 4AJF; 4AJG; 4AJM; 4BBX; 4DDL; 4DFF; 4FCB; 4FCD; 4HEU; 4HF4; 4LKQ; 4LLJ; 4LLK; 4LLP; 4LLX; 4LM0; 4LM1; 4LM2; 4LM3; 4LM4; 4MRW; 4MRZ; 4MS0; 4MSA; 4MSC; 4MSE; 4MSH; 4MSN; 4MUW; 4MVH; 4P0N; 4P1R; 4PHW; 4TPM; 4TPP; 4WN1; 4XY2; 4YQH; 4YS7; 4ZO5; 5AXP; 5AXQ; 5C1W; 5C28; 5C29; 5C2A; 5C2H	19.0%
9	IFNG	P01579	Interferon gamma	hsa03050; hsa04060; hsa04066; hsa04217; hsa04350; hsa04380; hsa04612; hsa04630; hsa04650; hsa04657; hsa04658; hsa04659; hsa04660; hsa04940; hsa05132; hsa05140; hsa05142; hsa05143; hsa05144; hsa05145; hsa05146; hsa05152; hsa05162; hsa05164; hsa05168; hsa05169; hsa05200; hsa05321; hsa05322; hsa05323; hsa05330; hsa05332; hsa05418	1EKU; 1FG9; 1FYH; 1HIG; 3BES	18.4%
10	AHR	P35869	Aryl hydrocarbon receptor	hsa04659; hsa04934	NA	17.0%
11	PTGS1	P23219	Prostaglandin G/H synthase 1	hsa00590; hsa01100; hsa04611; hsa04726; hsa04923	NA	16.4%
12	PDE7B	Q9NP56	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	hsa00230; hsa05032	1LXW	16.4%
13	EGFR	P00533	Epidermal growth factor receptor	hsa01521; hsa01522; hsa04010; hsa04012; hsa04014; hsa04015; hsa04020; hsa04066; hsa04068; hsa04072; hsa04144; hsa04151; hsa04510; hsa04520; hsa04540; hsa04630; hsa04810; hsa04912; hsa04915; hsa04921; hsa04926; hsa04928; hsa04934; hsa05120; hsa05160; hsa05163; hsa05165; hsa05200; hsa05205; hsa05206; hsa05210; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05219; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231	1DNQ; 1DNR; 1IVO; 1M14; 1M17; 1MOX; 1NQL; 1XKK; 1YY9; 1Z9I; 2EB2; 2EB3; 2EXP; 2EXQ; 2GS2; 2GS6; 2GS7; 2ITN; 2ITO; 2ITP; 2ITQ; 2ITT; 2ITU; 2ITV; 2ITW; 2ITX; 2ITY; 2ITZ; 2J5E; 2J5F; 2J6M; 2JIT; 2JIU; 2JIV; 2KS1; 2M0B; 2M20; 2N5S; 2RF9; 2RFD; 2RFE; 2RGP; 3B2U; 3B2V; 3BEL; 3BUO; 3C09; 3G5V; 3G5Y; 3GOP; 3GT8; 3IKA; 3LZB; 3NJP; 3OB2; 3OP0; 3P0Y; 3PFV; 3POZ; 3QWQ; 3UG1; 3UG2; 3VJN; 3VJO; 3VRP; 3VRR; 3W2O; 3W2P; 3W2Q; 3W2R; 3W2S; 3W32; 3W33; 4G5J; 4G5P; 4HJO; 4I1Z; 4I20; 4I21; 4I22; 4I23; 4I24; 4JQ7; 4JQ8; 4JR3; 4JRV; 4KRL; 4KRM; 4KRO; 4KRP; 4LI5; 4LL0; 4LQM; 4LRM; 4R3P; 4R3R; 4R5S; 4RIW; 4RIX; 4RIY; 4RJ4; 4RJ5; 4RJ6; 4RJ7; 4RJ8; 4TKS; 4UV7; 4WKQ; 4WRG; 4ZAU; 4ZJV; 5C8K; 5C8M; 5C8N; 5CAL; 5CAN; 5CAO; 5CAP; 5CAQ; 5CAS; 5CAU; 5CAV; 5CNN; 5CNO; 5CZH; 5CZI	16.2%
14	PDE5A	O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022	1RKP; 1T9R; 1T9S; 1TBF; 1UDT; 1UDU; 1UHO; 1XOZ; 1XP0; 2CHM; 2H40; 2H42; 2H44; 2XSS; 3B2R; 3BJC; 3HC8; 3HDZ; 3JWQ; 3JWR; 3LFV; 3MF0; 3SHY; 3SHZ; 3SIE; 3TGE; 3TGG; 4G2W; 4G2Y; 4I9Z; 4IA0; 4MD6; 4OEW; 4OEX	16.0%
15	PDE7A	Q13946	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	hsa00230; hsa05032	1ZKL; 3G3N; 4PM0; 4Y2B	15.1%
16	PDE6B	P35913	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	hsa00230; hsa04744	NA	14.3%
17	PDE2A	O00408	cGMP-dependent 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022; hsa04740; hsa04925; hsa05032	1Z1L; 3IBJ; 3ITM; 3ITU; 4C1I; 4D08; 4D09; 4HTX; 4HTZ; 4JIB	14.2%
18	GRIA1	P42261	Glutamate receptor 1	hsa04024; hsa04080; hsa04713; hsa04720; hsa04723; hsa04724; hsa04728; hsa04730; hsa05014; hsa05031; hsa05033	NA	13.9%
19	NOS3	P29474	Nitric oxide synthase, endothelial	hsa00220; hsa00330; hsa01100; hsa04020; hsa04022; hsa04066; hsa04071; hsa04151; hsa04370; hsa04371; hsa04611; hsa04915; hsa04921; hsa04926; hsa04931; hsa04933; hsa05418	1M9J; 1M9K; 1M9M; 1M9Q; 1M9R; 1NIW; 2LL7; 2MG5; 3EAH; 3NOS; 4D1O; 4D1P	13.3%
20	PLAT	P00750	Tissue-type plasminogen activator	hsa04371; hsa04610; hsa05202; hsa05215; hsa05418	1A5H; 1BDA; 1PK2; 1PML; 1RTF; 1TPG; 1TPK; 1TPM; 1TPN; 5BRR	13.2%