QuartataWeb 1.0

1 known interactions (targets) of input drug (DB02676): 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	PDE4D	Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	hsa00230; hsa04024; hsa04928; hsa05032	1E9K; 1MKD; 1OYN; 1PTW; 1Q9M; 1TB7; 1TBB; 1XOM; 1XON; 1XOQ; 1XOR; 1Y2B; 1Y2C; 1Y2D; 1Y2E; 1Y2K; 1ZKN; 2FM0; 2FM5; 2PW3; 2QYN; 3G4G; 3G4I; 3G4K; 3G4L; 3G58; 3IAD; 3IAK; 3K4S; 3SL3; 3SL4; 3SL5; 3SL6; 3SL8; 3V9B; 4OGB; 4W1O; 4WCU

20 predicted interactions (targets) of input drug (DB02676): 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	PDE4B	Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	hsa00230; hsa04024; hsa04928; hsa05032	1F0J; 1JP1; 1JP2; 1RO6; 1RO9; 1ROR; 1TB5; 1XLX; 1XLZ; 1XM4; 1XM6; 1XMU; 1XMY; 1XN0; 1XOS; 1XOT; 1Y2H; 1Y2J; 2CHM; 2QYL; 3D3P; 3FRG; 3G45; 3GWT; 3HC8; 3HDZ; 3HMV; 3KKT; 3LY2; 3O0J; 3O56; 3O57; 3W5E; 3WD9; 4KP6; 4MYQ; 4NW7; 4WZI; 4X0F	36.9%
2	PDE4A	P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	hsa00230; hsa04024; hsa04928; hsa05032	2QYK; 3I8V; 3TVX	31.3%
3	CHEK1	O14757	Serine/threonine-protein kinase Chk1	hsa04110; hsa04115; hsa04218; hsa05166; hsa05170; hsa05203	1IA8; 1NVQ; 1NVR; 1NVS; 1ZLT; 1ZYS; 2AYP; 2BR1; 2BRB; 2BRG; 2BRH; 2BRM; 2BRN; 2BRO; 2C3J; 2C3K; 2C3L; 2CGU; 2CGV; 2CGW; 2CGX; 2E9N; 2E9O; 2E9P; 2E9U; 2E9V; 2GDO; 2GHG; 2HOG; 2HXL; 2HXQ; 2HY0; 2QHM; 2QHN; 2R0U; 2WMQ; 2WMR; 2WMS; 2WMT; 2WMU; 2WMV; 2WMW; 2WMX; 2X8D; 2X8E; 2X8I; 2XEY; 2XEZ; 2XF0; 2YDI; 2YDJ; 2YDK; 2YER; 2YEX; 2YM3; 2YM4; 2YM5; 2YM6; 2YM7; 2YM8; 2YWP; 3F9N; 3JVR; 3JVS; 3NLB; 3OT3; 3OT8; 3PA3; 3PA4; 3PA5; 3TKH; 3TKI; 3U9N; 4FSM; 4FSN; 4FSQ; 4FSR; 4FST; 4FSU; 4FSW; 4FSY; 4FSZ; 4FT0; 4FT3; 4FT5; 4FT7; 4FT9; 4FTA; 4FTC; 4FTI; 4FTJ; 4FTK; 4FTL; 4FTM; 4FTN; 4FTO; 4FTQ; 4FTR; 4FTT; 4FTU; 4GH2; 4HYH; 4HYI; 4JIK; 4QYE; 4QYF; 4QYG; 4QYH; 4RVK; 4RVL; 4RVM; 5DLS	28.2%
4	PDE4C	Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	hsa00230; hsa04024; hsa04928; hsa05032	1LXU; 2QYM	27.0%
5	NOS2	P35228	Nitric oxide synthase, inducible	hsa00220; hsa00330; hsa01100; hsa04020; hsa04066; hsa04146; hsa04371; hsa04926; hsa05132; hsa05133; hsa05140; hsa05142; hsa05145; hsa05146; hsa05152; hsa05200; hsa05222	1NSI; 2LL6; 2NSI; 3E7G; 3EJ8; 3HR4; 4CX7; 4NOS	16.2%
6	PDE2A	O00408	cGMP-dependent 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022; hsa04740; hsa04925; hsa05032	1Z1L; 3IBJ; 3ITM; 3ITU; 4C1I; 4D08; 4D09; 4HTX; 4HTZ; 4JIB	16.0%
7	PDE3A	Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	hsa00230; hsa04022; hsa04024; hsa04924; hsa05032	1LRC	15.8%
8	PDE7A	Q13946	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	hsa00230; hsa05032	1ZKL; 3G3N; 4PM0; 4Y2B	15.5%
9	ADA	P00813	Adenosine deaminase	hsa00230; hsa01100; hsa05340	1M7M; 3IAR	14.7%
10	PRSS1	P07477	Trypsin-1	hsa04080; hsa04972; hsa04974; hsa05164	1FXY; 1TRN; 2RA3; 4WWY; 4WXV	12.9%
11	DHODH	Q02127	Dihydroorotate dehydrogenase (quinone), mitochondrial	hsa00240; hsa01100	1D3G; 1D3H; 2B0M; 2BXV; 2FPT; 2FPV; 2FPY; 2FQI; 2PRH; 2PRL; 2PRM; 2WV8; 3F1Q; 3FJ6; 3FJL; 3G0U; 3G0X; 3KVJ; 3KVK; 3KVL; 3KVM; 3U2O; 3W7R; 3ZWS; 3ZWT; 4IGH; 4JGD; 4JS3; 4JTS; 4JTT; 4JTU; 4LS0; 4LS1; 4LS2; 4OQV; 4RK8; 4RKA; 4RLI	12.5%
12	PDE8A	O60658	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	hsa00230; hsa04927; hsa04934; hsa05032	1LHQ; 1LXX; 3ECM; 3ECN	11.7%
13	AMD1	P17707	S-adenosylmethionine decarboxylase proenzyme	hsa00270; hsa00330; hsa01100	1I72; 1I79; 1I7B; 1I7C; 1I7M; 1JEN; 1JL0; 1MSV; 3DZ2; 3DZ3; 3DZ4; 3DZ5; 3DZ6; 3DZ7; 3EP3; 3EP4; 3EP5; 3EP6; 3EP7; 3EP8; 3EP9; 3EPA; 3EPB; 3H0V; 3H0W	11.7%
14	PDE5A	O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022	1RKP; 1T9R; 1T9S; 1TBF; 1UDT; 1UDU; 1UHO; 1XOZ; 1XP0; 2CHM; 2H40; 2H42; 2H44; 2XSS; 3B2R; 3BJC; 3HC8; 3HDZ; 3JWQ; 3JWR; 3LFV; 3MF0; 3SHY; 3SHZ; 3SIE; 3TGE; 3TGG; 4G2W; 4G2Y; 4I9Z; 4IA0; 4MD6; 4OEW; 4OEX	11.4%
15	IKBKG	Q9Y6K9	NF-kappa-B essential modulator	hsa01523; hsa04010; hsa04014; hsa04062; hsa04064; hsa04151; hsa04210; hsa04380; hsa04620; hsa04621; hsa04622; hsa04623; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04662; hsa04668; hsa04920; hsa05120; hsa05131; hsa05142; hsa05145; hsa05160; hsa05161; hsa05163; hsa05165; hsa05166; hsa05167; hsa05168; hsa05169; hsa05170; hsa05200; hsa05203; hsa05212; hsa05215; hsa05220; hsa05221; hsa05222; hsa05340; hsa05418	2JVX; 2JVY; 3BRT; 3BRV; 3CL3; 3FX0; 4BWN	11.3%
16	MET	P08581	Hepatocyte growth factor receptor	hsa01521; hsa04010; hsa04014; hsa04015; hsa04151; hsa04360; hsa04510; hsa04520; hsa05100; hsa05120; hsa05144; hsa05200; hsa05202; hsa05205; hsa05206; hsa05211; hsa05218; hsa05225; hsa05226; hsa05230	1FYR; 1R0P; 1R1W; 1SHY; 1SSL; 1UX3; 2G15; 2RFN; 2RFS; 2UZX; 2UZY; 2WD1; 2WGJ; 2WKM; 3A4P; 3BUX; 3C1X; 3CCN; 3CD8; 3CE3; 3CTH; 3CTJ; 3DKC; 3DKF; 3DKG; 3EFJ; 3EFK; 3F66; 3F82; 3I5N; 3L8V; 3LQ8; 3Q6U; 3Q6W; 3QTI; 3R7O; 3RHK; 3U6H; 3U6I; 3VW8; 3ZBX; 3ZC5; 3ZCL; 3ZXZ; 3ZZE; 4AOI; 4AP7; 4DEG; 4DEH; 4DEI; 4EEV; 4GG5; 4GG7; 4IWD; 4K3J; 4KNB; 4MXC; 4O3T; 4O3U; 4R1V; 4R1Y; 4XMO; 4XYF	11.1%
17	REN	P00797	Renin	hsa04614; hsa04924	1BBS; 1BIL; 1BIM; 1HRN; 1RNE; 2BKS; 2BKT; 2FS4; 2G1N; 2G1O; 2G1R; 2G1S; 2G1Y; 2G20; 2G21; 2G22; 2G24; 2G26; 2G27; 2I4Q; 2IKO; 2IKU; 2IL2; 2REN; 2V0Z; 2V10; 2V11; 2V12; 2V13; 2V16; 2X0B; 3D91; 3G6Z; 3G70; 3G72; 3GW5; 3K1W; 3KM4; 3O9L; 3OAD; 3OAG; 3OOT; 3OQF; 3OQK; 3OWN; 3Q3T; 3Q4B; 3Q5H; 3SFC; 3VCM; 3VSW; 3VSX; 3VUC; 3VYD; 3VYE; 3VYF; 4AMT; 4GJ5; 4GJ6; 4GJ7; 4GJ8; 4GJ9; 4GJA; 4GJB; 4GJC; 4GJD; 4PYV; 4Q1N; 4RYC; 4RYG; 4RZ1; 4S1G; 4XX3; 4XX4	11.0%
18	NOS3	P29474	Nitric oxide synthase, endothelial	hsa00220; hsa00330; hsa01100; hsa04020; hsa04022; hsa04066; hsa04071; hsa04151; hsa04370; hsa04371; hsa04611; hsa04915; hsa04921; hsa04926; hsa04931; hsa04933; hsa05418	1M9J; 1M9K; 1M9M; 1M9Q; 1M9R; 1NIW; 2LL7; 2MG5; 3EAH; 3NOS; 4D1O; 4D1P	11.0%
19	ADRB1	P08588	Beta-1 adrenergic receptor	hsa04020; hsa04022; hsa04024; hsa04080; hsa04261; hsa04540; hsa04923; hsa04924; hsa04970; hsa05414	2LSQ	10.3%
20	SCN3A	Q9NY46	Sodium channel protein type 3 subunit alpha	hsa04742	NA	10.3%