QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB02315
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB02315 Cyclic Guanosine Monophosphate Thumb


3 known interactions (targets) of input drug (DB02315): Cyclic Guanosine Monophosphate
No. Gene UniProt ID Protein Name Pathway PDB
1 PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase hsa00230; hsa04022; hsa04740; hsa04925; hsa05032 1Z1L; 3IBJ; 3ITM; 3ITU; 4C1I; 4D08; 4D09; 4HTX; 4HTZ; 4JIB
2 PRKAR1A P10644 cAMP-dependent protein kinase type I-alpha regulatory subunit hsa04910 NA
3 HCN2 Q9UL51 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 hsa04024 2MPF; 3U10


20 predicted interactions (targets) of input drug (DB02315): Cyclic Guanosine Monophosphate
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 PDE4D Q08499 cAMP-specific 3',5'-cyclic phosphodiesterase 4D hsa00230; hsa04024; hsa04928; hsa05032 39.5%
2 PDE5A O76074 cGMP-specific 3',5'-cyclic phosphodiesterase hsa00230; hsa04022 25.6%
3 PRKAR2B P31323 cAMP-dependent protein kinase type II-beta regulatory subunit hsa04910 NA 24.3%
4 PDE10A Q9Y233 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A hsa00230; hsa05032 23.8%
5 PDE8A O60658 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A hsa00230; hsa04927; hsa04934; hsa05032 1LHQ; 1LXX; 3ECM; 3ECN 21.2%
6 PDE4C Q08493 cAMP-specific 3',5'-cyclic phosphodiesterase 4C hsa00230; hsa04024; hsa04928; hsa05032 1LXU; 2QYM 21.1%
7 PDE9A O76083 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A hsa00230 20.5%
8 PDE6G P18545 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma hsa00230; hsa04744 3JWR 19.0%
9 RYR1 P21817 Ryanodine receptor 1 hsa04020; hsa04371; hsa04713; hsa04730; hsa04921 NA 17.9%
10 PDE7A Q13946 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A hsa00230; hsa05032 1ZKL; 3G3N; 4PM0; 4Y2B 17.6%
11 PYGL P06737 Glycogen phosphorylase, liver form hsa00500; hsa01100; hsa04217; hsa04910; hsa04922; hsa04931 1EM6; 1EXV; 1FA9; 1FC0; 1L5Q; 1L5R; 1L5S; 1L7X; 1XOI; 2ATI; 2QLL; 2ZB2; 3CEH; 3CEJ; 3CEM; 3DD1; 3DDS; 3DDW 17.6%
12 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 hsa01524; hsa03320; hsa04068; hsa04071; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04510; hsa04660; hsa04664; hsa04722; hsa04910; hsa04919; hsa04931; hsa04960; hsa05145; hsa05160; hsa05205; hsa05213; hsa05215; hsa05223; hsa05231 17.5%
13 YARS P54577 Tyrosine--tRNA ligase, cytoplasmic hsa00970 1N3L; 1NTG; 1Q11; 4Q93; 4QBT 17.4%
14 PDE4A P27815 cAMP-specific 3',5'-cyclic phosphodiesterase 4A hsa00230; hsa04024; hsa04928; hsa05032 2QYK; 3I8V; 3TVX 17.3%
15 BLVRB P30043 Flavin reductase (NADPH) hsa00740; hsa00860; hsa01100 1HDO; 1HE2; 1HE3; 1HE4; 1HE5 16.9%
16 PDE3B Q13370 cGMP-inhibited 3',5'-cyclic phosphodiesterase B hsa00230; hsa04022; hsa04024; hsa04371; hsa04910; hsa04914; hsa04922; hsa04923; hsa04924; hsa05032 1SO2; 1SOJ 16.8%
17 PYGM P11217 Glycogen phosphorylase, muscle form hsa00500; hsa01100; hsa04217; hsa04910; hsa04922; hsa04931 1Z8D 16.7%
18 PTGDR2 Q9Y5Y4 Prostaglandin D2 receptor 2 NA NA 16.3%
19 PDE2A Q8IW54 Phosphodiesterase 2A, cGMP-stimulated hsa00230; hsa04022; hsa04740; hsa04925; hsa05032 NA 16.1%
20 ATM Q13315 Serine-protein kinase ATM hsa01524; hsa03440; hsa04064; hsa04068; hsa04110; hsa04115; hsa04210; hsa04218; hsa05165; hsa05166; hsa05170; hsa05202; hsa05206 NA 16.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.