QuartataWeb 1.0

1 known interactions (targets) of input drug (DB06479): Propentofylline

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	PDE4A	P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	hsa00230; hsa04024; hsa04928; hsa05032	2QYK; 3I8V; 3TVX

20 predicted interactions (targets) of input drug (DB06479): Propentofylline

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	PDE4B	Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	hsa00230; hsa04024; hsa04928; hsa05032	1F0J; 1JP1; 1JP2; 1RO6; 1RO9; 1ROR; 1TB5; 1XLX; 1XLZ; 1XM4; 1XM6; 1XMU; 1XMY; 1XN0; 1XOS; 1XOT; 1Y2H; 1Y2J; 2CHM; 2QYL; 3D3P; 3FRG; 3G45; 3GWT; 3HC8; 3HDZ; 3HMV; 3KKT; 3LY2; 3O0J; 3O56; 3O57; 3W5E; 3WD9; 4KP6; 4MYQ; 4NW7; 4WZI; 4X0F	56.2%
2	PDE4D	Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	hsa00230; hsa04024; hsa04928; hsa05032	1E9K; 1MKD; 1OYN; 1PTW; 1Q9M; 1TB7; 1TBB; 1XOM; 1XON; 1XOQ; 1XOR; 1Y2B; 1Y2C; 1Y2D; 1Y2E; 1Y2K; 1ZKN; 2FM0; 2FM5; 2PW3; 2QYN; 3G4G; 3G4I; 3G4K; 3G4L; 3G58; 3IAD; 3IAK; 3K4S; 3SL3; 3SL4; 3SL5; 3SL6; 3SL8; 3V9B; 4OGB; 4W1O; 4WCU	42.6%
3	PDE4C	Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	hsa00230; hsa04024; hsa04928; hsa05032	1LXU; 2QYM	36.0%
4	ADORA2A	P29274	Adenosine receptor A2a	hsa04015; hsa04020; hsa04024; hsa04080; hsa04270; hsa05012; hsa05034	1MMH; 1UPE; 2YDO; 2YDV; 3EML; 3PWH; 3QAK; 3REY; 3RFM; 3UZA; 3UZC; 3VG9; 3VGA; 4EIY; 4UG2; 4UHR	29.2%
5	PDE3A	Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	hsa00230; hsa04022; hsa04024; hsa04924; hsa05032	1LRC	27.3%
6	ADORA1	P30542	Adenosine receptor A1	hsa04022; hsa04024; hsa04071; hsa04080; hsa04923; hsa04924; hsa05032	NA	25.5%
7	PDE5A	O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022	1RKP; 1T9R; 1T9S; 1TBF; 1UDT; 1UDU; 1UHO; 1XOZ; 1XP0; 2CHM; 2H40; 2H42; 2H44; 2XSS; 3B2R; 3BJC; 3HC8; 3HDZ; 3JWQ; 3JWR; 3LFV; 3MF0; 3SHY; 3SHZ; 3SIE; 3TGE; 3TGG; 4G2W; 4G2Y; 4I9Z; 4IA0; 4MD6; 4OEW; 4OEX	24.9%
8	RYR1	P21817	Ryanodine receptor 1	hsa04020; hsa04371; hsa04713; hsa04730; hsa04921	NA	18.7%
9	PDE10A	Q9Y233	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	hsa00230; hsa05032	1LRB; 2OUN; 2OUP; 2OUQ; 2OUR; 2OUS; 2OUU; 2OUV; 2OUY; 2WEY; 2Y0J; 2ZMF; 3SN7; 3SNI; 3SNL; 3UI7; 3UUO; 3WI2; 3WS8; 3WS9; 3WYK; 3WYL; 3WYM; 4AEL; 4AJD; 4AJF; 4AJG; 4AJM; 4BBX; 4DDL; 4DFF; 4FCB; 4FCD; 4HEU; 4HF4; 4LKQ; 4LLJ; 4LLK; 4LLP; 4LLX; 4LM0; 4LM1; 4LM2; 4LM3; 4LM4; 4MRW; 4MRZ; 4MS0; 4MSA; 4MSC; 4MSE; 4MSH; 4MSN; 4MUW; 4MVH; 4P0N; 4P1R; 4PHW; 4TPM; 4TPP; 4WN1; 4XY2; 4YQH; 4YS7; 4ZO5; 5AXP; 5AXQ; 5C1W; 5C28; 5C29; 5C2A; 5C2H	18.3%
10	PDE7A	Q13946	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	hsa00230; hsa05032	1ZKL; 3G3N; 4PM0; 4Y2B	17.7%
11	IFNG	P01579	Interferon gamma	hsa03050; hsa04060; hsa04066; hsa04217; hsa04350; hsa04380; hsa04612; hsa04630; hsa04650; hsa04657; hsa04658; hsa04659; hsa04660; hsa04940; hsa05132; hsa05140; hsa05142; hsa05143; hsa05144; hsa05145; hsa05146; hsa05152; hsa05162; hsa05164; hsa05168; hsa05169; hsa05200; hsa05321; hsa05322; hsa05323; hsa05330; hsa05332; hsa05418	1EKU; 1FG9; 1FYH; 1HIG; 3BES	17.1%
12	PLAT	P00750	Tissue-type plasminogen activator	hsa04371; hsa04610; hsa05202; hsa05215; hsa05418	1A5H; 1BDA; 1PK2; 1PML; 1RTF; 1TPG; 1TPK; 1TPM; 1TPN; 5BRR	16.7%
13	PDE2A	O00408	cGMP-dependent 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022; hsa04740; hsa04925; hsa05032	1Z1L; 3IBJ; 3ITM; 3ITU; 4C1I; 4D08; 4D09; 4HTX; 4HTZ; 4JIB	16.6%
14	PDE7B	Q9NP56	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	hsa00230; hsa05032	1LXW	15.2%
15	MAP3K1	Q13233	Mitogen-activated protein kinase kinase kinase 1	hsa04010; hsa04120; hsa04530; hsa04622; hsa04722; hsa04912; hsa05161; hsa05166	NA	14.5%
16	F2	P00734	Prothrombin	hsa04080; hsa04610; hsa04810	1A2C; 1A3B; 1A3E; 1A46; 1A4W; 1A5G; 1A61; 1ABI; 1ABJ; 1AD8; 1AE8; 1AFE; 1AHT; 1AI8; 1AIX; 1AWF; 1AWH; 1AY6; 1B5G; 1B7X; 1BA8; 1BB0; 1BCU; 1BHX; 1BMM; 1BMN; 1BTH; 1C1U; 1C1V; 1C1W; 1C4U; 1C4V; 1C4Y; 1C5L; 1C5N; 1C5O; 1CA8; 1D3D; 1D3P; 1D3Q; 1D3T; 1D4P; 1D6W; 1D9I; 1DE7; 1DIT; 1DM4; 1DOJ; 1DWB; 1DWC; 1DWD; 1DWE; 1DX5; 1E0F; 1EB1; 1EOJ; 1EOL; 1FPC; 1FPH; 1G30; 1G32; 1G37; 1GHV; 1GHW; 1GHX; 1GHY; 1GJ4; 1GJ5; 1H8D; 1H8I; 1HAG; 1HAH; 1HAI; 1HAO; 1HAP; 1HBT; 1HDT; 1HGT; 1HLT; 1HUT; 1HXE; 1HXF; 1IHS; 1IHT; 1JMO; 1JOU; 1JWT; 1K21; 1K22; 1KTS; 1KTT; 1LHC; 1LHD; 1LHE; 1LHF; 1LHG; 1MH0; 1MU6; 1MU8; 1MUE; 1NM6; 1NO9; 1NRN; 1NRO; 1NRP; 1NRQ; 1NRR; 1NRS; 1NT1; 1NU7; 1NU9; 1NY2; 1NZQ; 1O0D; 1O2G; 1O5G; 1OOK; 1OYT; 1P8V; 1PPB; 1QBV; 1QHR; 1QJ1; 1QJ6; 1QJ7; 1QUR; 1RD3; 1RIW; 1SB1; 1SFQ; 1SG8; 1SGI; 1SHH; 1SL3; 1SR5; 1T4U; 1T4V; 1TA2; 1TA6; 1TB6; 1TBZ; 1THP; 1THR; 1THS; 1TMB; 1TMT; 1TMU; 1TOM; 1TQ0; 1TQ7; 1TWX; 1UMA; 1UVS; 1VR1; 1VZQ; 1W7G; 1WAY; 1WBG; 1XM1; 1XMN; 1YPE; 1YPG; 1YPJ; 1YPK; 1YPL; 1YPM; 1Z71; 1Z8I; 1Z8J; 1ZGI; 1ZGV; 1ZRB; 2A0Q; 2A2X; 2A45; 2AFQ; 2ANK; 2ANM; 2B5T; 2BDY; 2BVR; 2BVS; 2BVX; 2BXT; 2BXU; 2C8W; 2C8X; 2C8Y; 2C8Z; 2C90; 2C93; 2CF8; 2CF9; 2CN0; 2FEQ; 2FES; 2GDE; 2GP9; 2H9T; 2HGT; 2HNT; 2HPP; 2HPQ; 2HWL; 2JH0; 2JH5; 2JH6; 2OD3; 2PGB; 2PGQ; 2PKS; 2PW8; 2R2M; 2THF; 2UUF; 2UUJ; 2UUK; 2V3H; 2V3O; 2ZC9; 2ZDA; 2ZDV; 2ZF0; 2ZFF; 2ZFP; 2ZFQ; 2ZFR; 2ZG0; 2ZGB; 2ZGX; 2ZHE; 2ZHF; 2ZHQ; 2ZHW; 2ZI2; 2ZIQ; 2ZNK; 2ZO3; 3B23; 3B9F; 3BEF; 3BEI; 3BF6; 3BIU; 3BIV; 3BV9; 3C1K; 3C27; 3D49; 3DA9; 3DD2; 3DHK; 3DT0; 3DUX; 3E6P; 3EE0; 3EGK; 3EQ0; 3F68; 3GIC; 3GIS; 3HAT; 3HKJ; 3HTC; 3JZ1; 3JZ2; 3K65; 3LDX; 3LU9; 3NXP; 3P17; 3P6Z; 3P70; 3PMH; 3PO1; 3QDZ; 3QGN; 3QLP; 3QTO; 3QTV; 3QWC; 3QX5; 3R3G; 3RLW; 3RLY; 3RM0; 3RM2; 3RML; 3RMM; 3RMN; 3RMO; 3S7H; 3S7K; 3SHA; 3SHC; 3SI3; 3SI4; 3SQE; 3SQH; 3SV2; 3T5F; 3TU7; 3U69; 3U8O; 3U8R; 3U8T; 3U98; 3U9A; 3UTU; 3UWJ; 3VXE; 3VXF; 4AX9; 4AYV; 4AYY; 4AZ2; 4BAH; 4BAK; 4BAM; 4BAN; 4BAO; 4BAQ; 4BOH; 4CH2; 4CH8; 4DIH; 4DII; 4DT7; 4DY7; 4E05; 4E06; 4E7R; 4H6S; 4H6T; 4HFP; 4HTC; 4HZH; 4I7Y; 4LOY; 4LXB; 4LZ1; 4LZ4; 4MLF; 4N3L; 4NZE; 4NZQ; 4O03; 4RKJ; 4RKO; 4RN6; 4THN; 4UD9; 4UDW; 4UE7; 4UEH; 4YES; 5AF9; 5AFY; 5AFZ; 5AHG; 5E8E; 5GDS; 7KME; 8KME	14.3%
17	PDE6B	P35913	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	hsa00230; hsa04744	NA	13.9%
18	EIF4E	P06730	Eukaryotic translation initiation factor 4E	hsa01521; hsa03013; hsa04066; hsa04150; hsa04151; hsa04211; hsa04910	1IPB; 1IPC; 1WKW; 2GPQ; 2V8W; 2V8X; 2V8Y; 2W97; 3AM7; 3TF2; 3U7X; 4AZA; 4BEA; 4DT6; 4DUM; 4TPW; 4TQB; 4TQC; 4UED; 5ABI	13.5%
19	EDNRA	P25101	Endothelin-1 receptor	hsa04020; hsa04022; hsa04024; hsa04080; hsa04270; hsa04924; hsa05200	NA	13.0%
20	ADRB3	P13945	Beta-3 adrenergic receptor	hsa04020; hsa04022; hsa04080; hsa04714; hsa04923; hsa04924; hsa04970	2CDW	12.8%