QuartataWeb 1.0

4 known interactions (targets) of input drug (DB00536): Guanidine

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	ALDH2	P05091	Aldehyde dehydrogenase, mitochondrial	hsa00010; hsa00053; hsa00071; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa01100	1CW3; 1NZW; 1NZX; 1NZZ; 1O00; 1O01; 1O02; 1O04; 1O05; 1ZUM; 2ONM; 2ONN; 2ONO; 2ONP; 2VLE; 3INJ; 3INL; 3N80; 3N81; 3N82; 3N83; 3SZ9; 4FQF; 4FR8; 4KWF; 4KWG
2	RNASE1	P07998	Ribonuclease pancreatic	NA	1DZA; 1E21; 1H8X; 1Z7X; 2E0J; 2E0L; 2E0M; 2E0O; 2K11; 2Q4G; 3F8G; 4KXH
3	DLG4	P78352	Disks large homolog 4	hsa04390; hsa04724; hsa05016; hsa05030	1KEF; 2MES; 3I4W; 3K82; 3ZRT
4	GAMT	Q14353	Guanidinoacetate N-methyltransferase	hsa00260; hsa00330; hsa01100	3ORH

20 predicted interactions (targets) of input drug (DB00536): Guanidine

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	CDK2	P24941	Cyclin-dependent kinase 2	hsa04068; hsa04110; hsa04114; hsa04115; hsa04151; hsa04218; hsa04914; hsa04934; hsa05161; hsa05162; hsa05165; hsa05168; hsa05169; hsa05200; hsa05203; hsa05215; hsa05222; hsa05226	1AQ1; 1B38; 1B39; 1BUH; 1CKP; 1DI8; 1DM2; 1E1V; 1E1X; 1E9H; 1F5Q; 1FIN; 1FQ1; 1FVT; 1FVV; 1G5S; 1GIH; 1GII; 1GIJ; 1GY3; 1GZ8; 1H00; 1H01; 1H07; 1H08; 1H0V; 1H0W; 1H1P; 1H1Q; 1H1R; 1H1S; 1H24; 1H25; 1H26; 1H27; 1H28; 1HCK; 1HCL; 1JST; 1JSU; 1JSV; 1JVP; 1KE5; 1KE6; 1KE7; 1KE8; 1KE9; 1OGU; 1OI9; 1OIQ; 1OIR; 1OIT; 1OIU; 1OIY; 1OKV; 1OKW; 1OL1; 1OL2; 1P2A; 1P5E; 1PF8; 1PKD; 1PW2; 1PXI; 1PXJ; 1PXK; 1PXL; 1PXM; 1PXN; 1PXO; 1PXP; 1PYE; 1QMZ; 1R78; 1URC; 1URW; 1V1K; 1VYW; 1VYZ; 1W0X; 1W8C; 1W98; 1WCC; 1Y8Y; 1Y91; 1YKR; 2A0C; 2A4L; 2B52; 2B53; 2B54; 2B55; 2BHE; 2BHH; 2BKZ; 2BPM; 2BTR; 2BTS; 2C4G; 2C5N; 2C5O; 2C5V; 2C5X; 2C5Y; 2C68; 2C69; 2C6I; 2C6K; 2C6L; 2C6M; 2C6O; 2C6T; 2CCH; 2CCI; 2CJM; 2CLX; 2DS1; 2DUV; 2EXM; 2FVD; 2G9X; 2HIC; 2I40; 2IW6; 2IW8; 2IW9; 2J9M; 2JGZ; 2R3F; 2R3G; 2R3H; 2R3I; 2R3J; 2R3K; 2R3L; 2R3M; 2R3N; 2R3O; 2R3P; 2R3Q; 2R3R; 2R64; 2UUE; 2UZB; 2UZD; 2UZE; 2UZL; 2UZN; 2UZO; 2V0D; 2V22; 2VTA; 2VTH; 2VTI; 2VTJ; 2VTL; 2VTM; 2VTN; 2VTO; 2VTP; 2VTQ; 2VTR; 2VTS; 2VTT; 2VU3; 2VV9; 2W05; 2W06; 2W17; 2W1H; 2WEV; 2WFY; 2WHB; 2WIH; 2WIP; 2WMA; 2WMB; 2WPA; 2WXV; 2X1N; 2XMY; 2XNB; 3BHT; 3BHU; 3BHV; 3DDP; 3DDQ; 3DOG; 3EID; 3EJ1; 3EOC; 3EZR; 3EZV; 3F5X; 3FZ1; 3IG7; 3IGG; 3LE6; 3LFN; 3LFQ; 3LFS; 3MY5; 3NS9; 3PJ8; 3PXF; 3PXQ; 3PXR; 3PXY; 3PXZ; 3PY0; 3PY1; 3QHR; 3QHW; 3QL8; 3QQF; 3QQG; 3QQH; 3QQJ; 3QQK; 3QQL; 3QRT; 3QRU; 3QTQ; 3QTR; 3QTS; 3QTU; 3QTW; 3QTX; 3QTZ; 3QU0; 3QWJ; 3QWK; 3QX2; 3QX4; 3QXO; 3QXP; 3QZF; 3QZG; 3QZH; 3QZI; 3R1Q; 3R1S; 3R1Y; 3R28; 3R6X; 3R71; 3R73; 3R7E; 3R7I; 3R7U; 3R7V; 3R7Y; 3R83; 3R8L; 3R8M; 3R8P; 3R8U; 3R8V; 3R8Z; 3R9D; 3R9H; 3R9N; 3R9O; 3RAH; 3RAI; 3RAK; 3RAL; 3RJC; 3RK5; 3RK7; 3RK9; 3RKB; 3RM6; 3RM7; 3RMF; 3RNI; 3ROY; 3RPO; 3RPR; 3RPV; 3RPY; 3RZB; 3S00; 3S0O; 3S1H; 3S2P; 3SQQ; 3SW4; 3SW7; 3TI1; 3TIY; 3TIZ; 3TNW; 3ULI; 3UNJ; 3UNK; 3WBL; 4ACM; 4BCK; 4BCM; 4BCN; 4BCO; 4BCP; 4BCQ; 4BGH; 4BZD; 4CFM; 4CFN; 4CFU; 4CFV; 4CFW; 4CFX; 4D1X; 4D1Z; 4EK3; 4EK4; 4EK5; 4EK6; 4EK8; 4EOI; 4EOJ; 4EOK; 4EOL; 4EOM; 4EON; 4EOO; 4EOP; 4EOQ; 4EOR; 4EOS; 4ERW; 4EZ3; 4EZ7; 4FKG; 4FKI; 4FKJ; 4FKL; 4FKO; 4FKP; 4FKQ; 4FKR; 4FKS; 4FKT; 4FKU; 4FKV; 4FKW; 4FX3; 4GCJ; 4I3Z; 4II5; 4KD1; 4LYN; 4NJ3; 4RJ3; 5A14; 5CYI; 5D1J	20.8%
2	RNASE3	P12724	Eosinophil cationic protein	hsa05310	1DYT; 1H1H; 1QMT; 2KB5; 2LVZ; 4A2O; 4A2Y; 4OWZ; 4OXB; 4OXF; 4X08	20.3%
3	GNMT	Q14749	Glycine N-methyltransferase	hsa00260	1R74; 2AZT	19.8%
4	HNMT	P50135	Histamine N-methyltransferase	hsa00340	1ICZ; 1JQD; 1JQE; 2AOT; 2AOU; 2AOV; 2AOW; 2AOX	19.8%
5	ESR1	P03372	Estrogen receptor	hsa01522; hsa04915; hsa04917; hsa04919; hsa04961; hsa05200; hsa05205; hsa05224	1A52; 1AKF; 1ERE; 1ERR; 1G50; 1GWQ; 1GWR; 1HCP; 1HCQ; 1L2I; 1PCG; 1QKT; 1QKU; 1R5K; 1SJ0; 1UOM; 1X7E; 1X7R; 1XP1; 1XP6; 1XP9; 1XPC; 1XQC; 1YIM; 1YIN; 1ZKY; 2AYR; 2B1V; 2B1Z; 2B23; 2BJ4; 2FAI; 2G44; 2G5O; 2I0J; 2IOG; 2IOK; 2JF9; 2JFA; 2LLO; 2LLQ; 2OCF; 2OUZ; 2P15; 2POG; 2Q6J; 2Q70; 2QA6; 2QA8; 2QAB; 2QE4; 2QGT; 2QGW; 2QH6; 2QR9; 2QSE; 2QXM; 2QXS; 2QZO; 2R6W; 2R6Y; 2YAT; 2YJA; 3CBM; 3CBO; 3CBP; 3DT3; 3ERD; 3ERT; 3HLV; 3HM1; 3L03; 3OS8; 3OS9; 3OSA; 3Q95; 3Q97; 3UU7; 3UUA; 3UUC; 3UUD; 4AA6; 4DMA; 4IU7; 4IUI; 4IV2; 4IV4; 4IVW; 4IVY; 4IW6; 4IW8; 4IWC; 4IWF; 4JC3; 4JDD; 4MG5; 4MG6; 4MG7; 4MG8; 4MG9; 4MGA; 4MGB; 4MGC; 4MGD; 4O6F; 4PP6; 4PPP; 4PPS; 4PXM; 4Q13; 4Q50; 4TUZ; 4TV1; 4ZN9; 5AAU; 5AAV; 5AK2	19.7%
6	MMP3	P08254	Stromelysin-1	hsa04657; hsa04668; hsa05202; hsa05215; hsa05323	1B3D; 1B8Y; 1BIW; 1BM6; 1BQO; 1C3I; 1C8T; 1CAQ; 1CIZ; 1CQR; 1D5J; 1D7X; 1D8F; 1D8M; 1G05; 1G49; 1G4K; 1HFS; 1HY7; 1M1W; 1OO9; 1QIA; 1QIC; 1SLM; 1SLN; 1UEA; 1UMS; 1UMT; 1USN; 2D1O; 2JNP; 2JT5; 2JT6; 2SRT; 2USN; 3OHL; 3OHO; 3USN; 4DPE; 4G9L; 4JA1	19.7%
7	CKB	P12277	Creatine kinase B-type	hsa00330; hsa01100	3B6R; 3DRB; 3DRE	19.5%
8	PARP1	P09874	Poly [ADP-ribose] polymerase 1	hsa03410; hsa04064; hsa04210; hsa04217	1UK0; 1UK1; 1WOK; 2COK; 2CR9; 2CS2; 2DMJ; 2JVN; 2L30; 2L31; 2RCW; 2RD6; 2RIQ; 3GJW; 3GN7; 3L3L; 3L3M; 3OD8; 3ODA; 3ODC; 3ODE; 4AV1; 4DQY; 4GV7; 4HHY; 4HHZ; 4L6S; 4OPX; 4OQA; 4OQB; 4PJT; 4R5W; 4R6E; 4UND; 4UXB; 4XHU; 4ZZZ; 5A00	19.4%
9	SULT2A1	Q06520	Bile salt sulfotransferase	hsa00980; hsa04976; hsa05204	1EFH; 1J99; 1OV4; 2QP3; 2QP4; 3F3Y; 4IFB	18.6%
10	SLC6A8	P48029	Sodium- and chloride-dependent creatine transporter 1	NA	NA	18.5%
11	MMP8	P22894	Neutrophil collagenase	NA	1A85; 1A86; 1BZS; 1I73; 1I76; 1JAN; 1JAO; 1JAP; 1JAQ; 1JH1; 1JJ9; 1KBC; 1MMB; 1MNC; 1ZP5; 1ZS0; 1ZVX; 2OY2; 2OY4; 3DNG; 3DPE; 3DPF; 3TT4; 4QKZ	18.3%
12	CKM	P06732	Creatine kinase M-type	hsa00330; hsa01100	1I0E	17.8%
13	HMGCR	P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	hsa00900; hsa01100; hsa04152; hsa04976	1DQ8; 1DQ9; 1DQA; 1HW8; 1HW9; 1HWI; 1HWJ; 1HWK; 1HWL; 2Q1L; 2Q6B; 2Q6C; 2R4F; 3BGL; 3CCT; 3CCW; 3CCZ; 3CD0; 3CD5; 3CD7; 3CDA; 3CDB	17.8%
14	COMTD1	Q86VU5	Catechol O-methyltransferase domain-containing protein 1	NA	2AVD	17.6%
15	CKMT1A	P12532	Creatine kinase U-type, mitochondrial	NA	1QK1	17.5%
16	MAPK8	P45983	Mitogen-activated protein kinase 8	hsa01522; hsa04010; hsa04012; hsa04014; hsa04024; hsa04068; hsa04071; hsa04137; hsa04140; hsa04141; hsa04210; hsa04215; hsa04217; hsa04310; hsa04380; hsa04510; hsa04530; hsa04620; hsa04621; hsa04622; hsa04625; hsa04657; hsa04658; hsa04659; hsa04664; hsa04668; hsa04722; hsa04723; hsa04728; hsa04750; hsa04910; hsa04912; hsa04914; hsa04917; hsa04920; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa05120; hsa05131; hsa05132; hsa05133; hsa05142; hsa05145; hsa05152; hsa05160; hsa05161; hsa05164; hsa05166; hsa05167; hsa05168; hsa05169; hsa05170; hsa05200; hsa05210; hsa05212; hsa05231; hsa05418	1UKH; 1UKI; 2G01; 2GMX; 2H96; 2NO3; 2XRW; 2XS0; 3ELJ; 3O17; 3O2M; 3PZE; 3V3V; 3VUD; 3VUG; 3VUH; 3VUI; 3VUK; 3VUL; 3VUM; 4AWI; 4E73; 4G1W; 4HYS; 4HYU; 4IZY; 4L7F; 4QTD; 4UX9	17.0%
17	PDE5A	O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022	1RKP; 1T9R; 1T9S; 1TBF; 1UDT; 1UDU; 1UHO; 1XOZ; 1XP0; 2CHM; 2H40; 2H42; 2H44; 2XSS; 3B2R; 3BJC; 3HC8; 3HDZ; 3JWQ; 3JWR; 3LFV; 3MF0; 3SHY; 3SHZ; 3SIE; 3TGE; 3TGG; 4G2W; 4G2Y; 4I9Z; 4IA0; 4MD6; 4OEW; 4OEX	16.6%
18	TRPA1	O75762	Transient receptor potential cation channel subfamily A member 1	hsa04750	3J9P	16.0%
19	MAPK8IP1	Q9UQF2	C-Jun-amino-terminal kinase-interacting protein 1	hsa04010	2G01; 2GMX; 2H96; 3OXI; 3PTG; 3VUD; 3VUG; 3VUH; 3VUI; 3VUK; 3VUL; 3VUM; 4E73; 4G1W; 4H39; 4HYS; 4HYU; 4IZY	15.7%
20	AVPR1A	P37288	Vasopressin V1a receptor	hsa04020; hsa04072; hsa04080; hsa04270	1YTV	15.6%