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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB03088
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB03088 Pidolic Acid Thumb


12 known interactions (targets) of input drug (DB03088): Pidolic Acid
No. Gene UniProt ID Protein Name Pathway PDB
1 CCL8 P80075 C-C motif chemokine 8 hsa04060; hsa04062 1ESR
2 AMY2B P19961 Alpha-amylase 2B hsa00500; hsa01100; hsa04972; hsa04973 NA
3 ANG P03950 Angiogenin NA
4 AMY2A P04746 Pancreatic alpha-amylase hsa00500; hsa01100; hsa04972; hsa04973
5 ADAM28 Q9UKQ2 Disintegrin and metalloproteinase domain-containing protein 28 NA NA
6 HCRT O43612 Orexin NA 1CQ0; 1R02; 1UVQ; 1WSO
7 VEGFA P15692 Vascular endothelial growth factor A hsa01521; hsa04010; hsa04014; hsa04015; hsa04066; hsa04151; hsa04370; hsa04510; hsa04926; hsa04933; hsa05163; hsa05165; hsa05167; hsa05200; hsa05205; hsa05206; hsa05211; hsa05212; hsa05219; hsa05323; hsa05418
8 KRTAP5-2 Q701N4 Keratin-associated protein 5-2 NA NA
9 IGLC1 P0CG04 Ig lambda-1 chain C regions NA 1ZVO; 2FB4; 2IG2
10 TFF2 Q03403 Trefoil factor 2 NA NA
11 AMY1A P04745 Alpha-amylase 1 NA 1C8Q; 1JXJ; 1JXK; 1MFU; 1MFV; 1NM9; 1Q4N; 1SMD; 1XV8; 1Z32; 3BLK; 3BLP; 3DHP
12 NA P01709 Ig lambda chain V-II region MGC NA 1A8J; 1DCL; 1MCW; 2MCG; 3MCG; 4UNT; 4UNU; 4UNV


20 predicted interactions (targets) of input drug (DB03088): Pidolic Acid
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 ANXA5 P08758 Annexin A5 NA 1ANW; 1ANX; 1AVH; 1AVR; 1HAK; 1HVD; 1HVE; 1HVF; 1HVG; 1SAV; 2XO2; 2XO3 33.5%
2 CHRFAM7A Q494W8 CHRNA7-FAM7A fusion protein NA NA 32.5%
3 ADORA2A P29274 Adenosine receptor A2a hsa04015; hsa04020; hsa04024; hsa04080; hsa04270; hsa05012; hsa05034 1MMH; 1UPE; 2YDO; 2YDV; 3EML; 3PWH; 3QAK; 3REY; 3RFM; 3UZA; 3UZC; 3VG9; 3VGA; 4EIY; 4UG2; 4UHR 27.4%
4 IFNAR2 P48551 Interferon alpha/beta receptor 2 hsa04060; hsa04151; hsa04217; hsa04380; hsa04620; hsa04621; hsa04630; hsa04650; hsa05160; hsa05162; hsa05164; hsa05165; hsa05167; hsa05168; hsa05200 1N6U; 1N6V; 2HYM; 2KZ1; 2LAG; 3S8W; 3S9D; 3SE3; 3SE4 26.3%
5 DHODH Q02127 Dihydroorotate dehydrogenase (quinone), mitochondrial hsa00240; hsa01100 26.3%
6 PDE5A O76074 cGMP-specific 3',5'-cyclic phosphodiesterase hsa00230; hsa04022 24.7%
7 PNLIP P16233 Pancreatic triacylglycerol lipase hsa00561; hsa01100; hsa04972; hsa04975; hsa04977 1LPA; 1LPB; 1N8S 24.7%
8 RARB P10826 Retinoic acid receptor beta hsa05200; hsa05222; hsa05223; hsa05226 1HRA; 1XAP; 4DM6; 4DM8; 4JYG; 4JYH; 4JYI 24.1%
9 RNASE1 P07998 Ribonuclease pancreatic NA 1DZA; 1E21; 1H8X; 1Z7X; 2E0J; 2E0L; 2E0M; 2E0O; 2K11; 2Q4G; 3F8G; 4KXH 23.7%
10 CTSF Q9UBX1 Cathepsin F hsa04142; hsa04210 1D5U; 1M6D 23.0%
11 ACACB O00763 Acetyl-CoA carboxylase 2 hsa00061; hsa00620; hsa00640; hsa01100; hsa04152; hsa04910; hsa04920; hsa04922; hsa04931 2DN8; 2HJW; 2KCC; 3FF6; 3GID; 3GLK; 3JRW; 3JRX; 3TDC; 4HQ6 22.3%
12 PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase hsa00230; hsa04022; hsa04740; hsa04925; hsa05032 1Z1L; 3IBJ; 3ITM; 3ITU; 4C1I; 4D08; 4D09; 4HTX; 4HTZ; 4JIB 22.2%
13 MMP8 P22894 Neutrophil collagenase NA 21.4%
14 UQCRH P07919 Cytochrome b-c1 complex subunit 6, mitochondrial hsa00190; hsa01100; hsa04260; hsa04714; hsa04932; hsa05010; hsa05012; hsa05016 NA 21.2%
15 SERPINA1 P01009 Alpha-1-antitrypsin hsa04610 21.1%
16 IFNAR1 P17181 Interferon alpha/beta receptor 1 hsa04060; hsa04151; hsa04217; hsa04380; hsa04620; hsa04621; hsa04630; hsa04650; hsa05160; hsa05161; hsa05162; hsa05164; hsa05165; hsa05167; hsa05168; hsa05200 3S98; 3SE3; 3SE4; 4PO6 20.8%
17 PRSS1 P07477 Trypsin-1 hsa04080; hsa04972; hsa04974; hsa05164 1FXY; 1TRN; 2RA3; 4WWY; 4WXV 20.6%
18 RARG P13631 Retinoic acid receptor gamma NA 1EXA; 1EXX; 1FCX; 1FCY; 1FCZ; 1FD0; 2LBD; 3LBD; 4LBD 20.5%
19 QPCT Q16769 Glutaminyl-peptide cyclotransferase NA 20.1%
20 FURIN P09958 Furin hsa05164 4OMC; 4OMD; 4RYD 20.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.