QuartataWeb 1.0

32 known interactions (targets) of input drug (DB00201): Caffeine

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	PDE6C	P51160	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	hsa00230	3JWQ; 3JWR; 5E8F
2	ADORA1	P30542	Adenosine receptor A1	hsa04022; hsa04024; hsa04071; hsa04080; hsa04923; hsa04924; hsa05032	5MZP; 3RFM;
3	PDE6B	P35913	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	hsa00230; hsa04744	NA
4	PIK3CA	P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	hsa00562; hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa04960; hsa04973; hsa05100; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05170; hsa05200; hsa05203; hsa05205; hsa05206; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05418	2ENQ; 2RD0; 3HHM; 3HIZ; 3ZIM; 4JPS; 4L1B; 4L23; 4L2Y; 4OVU; 4OVV; 4TUU; 4TV3; 4WAF; 4YKN
5	PDE11A	Q9HCR9	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	hsa00230; hsa04934; hsa05032	NA
6	PDE5A	O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022	1RKP; 1T9R; 1T9S; 1TBF; 1UDT; 1UDU; 1UHO; 1XOZ; 1XP0; 2CHM; 2H40; 2H42; 2H44; 2XSS; 3B2R; 3BJC; 3HC8; 3HDZ; 3JWQ; 3JWR; 3LFV; 3MF0; 3SHY; 3SHZ; 3SIE; 3TGE; 3TGG; 4G2W; 4G2Y; 4I9Z; 4IA0; 4MD6; 4OEW; 4OEX
7	PDE4C	Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	hsa00230; hsa04024; hsa04928; hsa05032	1LXU; 2QYM
8	PDE4B	Q07343	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	hsa00230; hsa04024; hsa04928; hsa05032	1F0J; 1JP1; 1JP2; 1RO6; 1RO9; 1ROR; 1TB5; 1XLX; 1XLZ; 1XM4; 1XM6; 1XMU; 1XMY; 1XN0; 1XOS; 1XOT; 1Y2H; 1Y2J; 2CHM; 2QYL; 3D3P; 3FRG; 3G45; 3GWT; 3HC8; 3HDZ; 3HMV; 3KKT; 3LY2; 3O0J; 3O56; 3O57; 3W5E; 3WD9; 4KP6; 4MYQ; 4NW7; 4WZI; 4X0F
9	PDE1C	Q14123	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032	1LXS
10	ITPR1	Q14643	Inositol 1,4,5-trisphosphate receptor type 1	hsa04020; hsa04022; hsa04070; hsa04114; hsa04140; hsa04210; hsa04218; hsa04270; hsa04371; hsa04540; hsa04611; hsa04621; hsa04625; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04728; hsa04730; hsa04750; hsa04912; hsa04915; hsa04918; hsa04921; hsa04922; hsa04924; hsa04925; hsa04927; hsa04928; hsa04934; hsa04970; hsa04971; hsa04972; hsa05010; hsa05016; hsa05163; hsa05167; hsa05170; hsa05205	NA
11	ATM	Q13315	Serine-protein kinase ATM	hsa01524; hsa03440; hsa04064; hsa04068; hsa04110; hsa04115; hsa04210; hsa04218; hsa05165; hsa05166; hsa05170; hsa05202; hsa05206	NA
12	PDE1A	P54750	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032	1LXQ
13	PDE7B	Q9NP56	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	hsa00230; hsa05032	1LXW
14	PDE8B	O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	hsa00230; hsa04927; hsa04934; hsa05032	NA
15	PDE9A	O76083	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	hsa00230	2HD1; 2YY2; 3DY8; 3DYL; 3DYN; 3DYQ; 3DYS; 3JSI; 3JSW; 3K3E; 3K3H; 3N3Z; 3QI3; 3QI4; 4E90; 4G2J; 4G2L; 4GH6; 4Y86; 4Y87; 4Y8C
16	PDE10A	Q9Y233	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	hsa00230; hsa05032	1LRB; 2OUN; 2OUP; 2OUQ; 2OUR; 2OUS; 2OUU; 2OUV; 2OUY; 2WEY; 2Y0J; 2ZMF; 3SN7; 3SNI; 3SNL; 3UI7; 3UUO; 3WI2; 3WS8; 3WS9; 3WYK; 3WYL; 3WYM; 4AEL; 4AJD; 4AJF; 4AJG; 4AJM; 4BBX; 4DDL; 4DFF; 4FCB; 4FCD; 4HEU; 4HF4; 4LKQ; 4LLJ; 4LLK; 4LLP; 4LLX; 4LM0; 4LM1; 4LM2; 4LM3; 4LM4; 4MRW; 4MRZ; 4MS0; 4MSA; 4MSC; 4MSE; 4MSH; 4MSN; 4MUW; 4MVH; 4P0N; 4P1R; 4PHW; 4TPM; 4TPP; 4WN1; 4XY2; 4YQH; 4YS7; 4ZO5; 5AXP; 5AXQ; 5C1W; 5C28; 5C29; 5C2A; 5C2H
17	PDE4A	P27815	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	hsa00230; hsa04024; hsa04928; hsa05032	2QYK; 3I8V; 3TVX
18	PIK3CB	P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	hsa00562; hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa04960; hsa04973; hsa05100; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05170; hsa05200; hsa05203; hsa05205; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05418	NA
19	RYR1	P21817	Ryanodine receptor 1	hsa04020; hsa04371; hsa04713; hsa04730; hsa04921	NA
20	ADORA2A	P29274	Adenosine receptor A2a	hsa04015; hsa04020; hsa04024; hsa04080; hsa04270; hsa05012; hsa05034	3RFM; 5MZP; 1MMH; 1UPE; 2YDO; 2YDV; 3EML; 3PWH; 3QAK; 3REY; 3RFM; 3UZA; 3UZC; 3VG9; 3VGA; 4EIY; 4UG2; 4UHR
21	ITPR3	Q14573	Inositol 1,4,5-trisphosphate receptor type 3	hsa04020; hsa04022; hsa04070; hsa04114; hsa04210; hsa04218; hsa04270; hsa04371; hsa04540; hsa04611; hsa04621; hsa04625; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04728; hsa04730; hsa04742; hsa04750; hsa04911; hsa04912; hsa04915; hsa04918; hsa04921; hsa04922; hsa04924; hsa04925; hsa04927; hsa04928; hsa04934; hsa04970; hsa04971; hsa04972; hsa05010; hsa05163; hsa05167; hsa05170; hsa05205	NA
22	PDE4D	Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	hsa00230; hsa04024; hsa04928; hsa05032	1E9K; 1MKD; 1OYN; 1PTW; 1Q9M; 1TB7; 1TBB; 1XOM; 1XON; 1XOQ; 1XOR; 1Y2B; 1Y2C; 1Y2D; 1Y2E; 1Y2K; 1ZKN; 2FM0; 2FM5; 2PW3; 2QYN; 3G4G; 3G4I; 3G4K; 3G4L; 3G58; 3IAD; 3IAK; 3K4S; 3SL3; 3SL4; 3SL5; 3SL6; 3SL8; 3V9B; 4OGB; 4W1O; 4WCU
23	PDE7A	Q13946	High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	hsa00230; hsa05032	1ZKL; 3G3N; 4PM0; 4Y2B
24	PDE8A	O60658	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	hsa00230; hsa04927; hsa04934; hsa05032	1LHQ; 1LXX; 3ECM; 3ECN
25	PIK3CD	O00329	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	hsa00562; hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa04960; hsa04973; hsa05100; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05170; hsa05200; hsa05203; hsa05205; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05418	NA
26	PDE2A	O00408	cGMP-dependent 3',5'-cyclic phosphodiesterase	hsa00230; hsa04022; hsa04740; hsa04925; hsa05032	1Z1L; 3IBJ; 3ITM; 3ITU; 4C1I; 4D08; 4D09; 4HTX; 4HTZ; 4JIB
27	PDE3B	Q13370	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	hsa00230; hsa04022; hsa04024; hsa04371; hsa04910; hsa04914; hsa04922; hsa04923; hsa04924; hsa05032	1SO2; 1SOJ
28	PDE1B	Q01064	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032	1LXR; 1TAZ; 4NPV; 4NPW
29	PDE3A	Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	hsa00230; hsa04022; hsa04024; hsa04924; hsa05032	1LRC
30	ITPR2	Q14571	Inositol 1,4,5-trisphosphate receptor type 2	hsa04020; hsa04022; hsa04070; hsa04114; hsa04210; hsa04218; hsa04270; hsa04371; hsa04540; hsa04611; hsa04621; hsa04625; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04728; hsa04730; hsa04750; hsa04912; hsa04915; hsa04918; hsa04921; hsa04922; hsa04924; hsa04925; hsa04927; hsa04928; hsa04934; hsa04970; hsa04971; hsa04972; hsa05010; hsa05163; hsa05167; hsa05170; hsa05205	NA
31	PDE6A	P16499	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	hsa00230; hsa04744	NA
32	PRKDC	P78527	DNA-dependent protein kinase catalytic subunit	hsa03450; hsa04110	NA

20 predicted interactions (targets) of input drug (DB00201): Caffeine

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	F2	P00734	Prothrombin	hsa04080; hsa04610; hsa04810	1A2C; 1A3B; 1A3E; 1A46; 1A4W; 1A5G; 1A61; 1ABI; 1ABJ; 1AD8; 1AE8; 1AFE; 1AHT; 1AI8; 1AIX; 1AWF; 1AWH; 1AY6; 1B5G; 1B7X; 1BA8; 1BB0; 1BCU; 1BHX; 1BMM; 1BMN; 1BTH; 1C1U; 1C1V; 1C1W; 1C4U; 1C4V; 1C4Y; 1C5L; 1C5N; 1C5O; 1CA8; 1D3D; 1D3P; 1D3Q; 1D3T; 1D4P; 1D6W; 1D9I; 1DE7; 1DIT; 1DM4; 1DOJ; 1DWB; 1DWC; 1DWD; 1DWE; 1DX5; 1E0F; 1EB1; 1EOJ; 1EOL; 1FPC; 1FPH; 1G30; 1G32; 1G37; 1GHV; 1GHW; 1GHX; 1GHY; 1GJ4; 1GJ5; 1H8D; 1H8I; 1HAG; 1HAH; 1HAI; 1HAO; 1HAP; 1HBT; 1HDT; 1HGT; 1HLT; 1HUT; 1HXE; 1HXF; 1IHS; 1IHT; 1JMO; 1JOU; 1JWT; 1K21; 1K22; 1KTS; 1KTT; 1LHC; 1LHD; 1LHE; 1LHF; 1LHG; 1MH0; 1MU6; 1MU8; 1MUE; 1NM6; 1NO9; 1NRN; 1NRO; 1NRP; 1NRQ; 1NRR; 1NRS; 1NT1; 1NU7; 1NU9; 1NY2; 1NZQ; 1O0D; 1O2G; 1O5G; 1OOK; 1OYT; 1P8V; 1PPB; 1QBV; 1QHR; 1QJ1; 1QJ6; 1QJ7; 1QUR; 1RD3; 1RIW; 1SB1; 1SFQ; 1SG8; 1SGI; 1SHH; 1SL3; 1SR5; 1T4U; 1T4V; 1TA2; 1TA6; 1TB6; 1TBZ; 1THP; 1THR; 1THS; 1TMB; 1TMT; 1TMU; 1TOM; 1TQ0; 1TQ7; 1TWX; 1UMA; 1UVS; 1VR1; 1VZQ; 1W7G; 1WAY; 1WBG; 1XM1; 1XMN; 1YPE; 1YPG; 1YPJ; 1YPK; 1YPL; 1YPM; 1Z71; 1Z8I; 1Z8J; 1ZGI; 1ZGV; 1ZRB; 2A0Q; 2A2X; 2A45; 2AFQ; 2ANK; 2ANM; 2B5T; 2BDY; 2BVR; 2BVS; 2BVX; 2BXT; 2BXU; 2C8W; 2C8X; 2C8Y; 2C8Z; 2C90; 2C93; 2CF8; 2CF9; 2CN0; 2FEQ; 2FES; 2GDE; 2GP9; 2H9T; 2HGT; 2HNT; 2HPP; 2HPQ; 2HWL; 2JH0; 2JH5; 2JH6; 2OD3; 2PGB; 2PGQ; 2PKS; 2PW8; 2R2M; 2THF; 2UUF; 2UUJ; 2UUK; 2V3H; 2V3O; 2ZC9; 2ZDA; 2ZDV; 2ZF0; 2ZFF; 2ZFP; 2ZFQ; 2ZFR; 2ZG0; 2ZGB; 2ZGX; 2ZHE; 2ZHF; 2ZHQ; 2ZHW; 2ZI2; 2ZIQ; 2ZNK; 2ZO3; 3B23; 3B9F; 3BEF; 3BEI; 3BF6; 3BIU; 3BIV; 3BV9; 3C1K; 3C27; 3D49; 3DA9; 3DD2; 3DHK; 3DT0; 3DUX; 3E6P; 3EE0; 3EGK; 3EQ0; 3F68; 3GIC; 3GIS; 3HAT; 3HKJ; 3HTC; 3JZ1; 3JZ2; 3K65; 3LDX; 3LU9; 3NXP; 3P17; 3P6Z; 3P70; 3PMH; 3PO1; 3QDZ; 3QGN; 3QLP; 3QTO; 3QTV; 3QWC; 3QX5; 3R3G; 3RLW; 3RLY; 3RM0; 3RM2; 3RML; 3RMM; 3RMN; 3RMO; 3S7H; 3S7K; 3SHA; 3SHC; 3SI3; 3SI4; 3SQE; 3SQH; 3SV2; 3T5F; 3TU7; 3U69; 3U8O; 3U8R; 3U8T; 3U98; 3U9A; 3UTU; 3UWJ; 3VXE; 3VXF; 4AX9; 4AYV; 4AYY; 4AZ2; 4BAH; 4BAK; 4BAM; 4BAN; 4BAO; 4BAQ; 4BOH; 4CH2; 4CH8; 4DIH; 4DII; 4DT7; 4DY7; 4E05; 4E06; 4E7R; 4H6S; 4H6T; 4HFP; 4HTC; 4HZH; 4I7Y; 4LOY; 4LXB; 4LZ1; 4LZ4; 4MLF; 4N3L; 4NZE; 4NZQ; 4O03; 4RKJ; 4RKO; 4RN6; 4THN; 4UD9; 4UDW; 4UE7; 4UEH; 4YES; 5AF9; 5AFY; 5AFZ; 5AHG; 5E8E; 5GDS; 7KME; 8KME	41.9%
2	PRKACA	P17612	cAMP-dependent protein kinase catalytic subunit alpha	hsa01522; hsa04010; hsa04014; hsa04020; hsa04024; hsa04062; hsa04114; hsa04140; hsa04211; hsa04213; hsa04261; hsa04270; hsa04310; hsa04340; hsa04371; hsa04530; hsa04540; hsa04611; hsa04713; hsa04714; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04740; hsa04742; hsa04750; hsa04910; hsa04911; hsa04912; hsa04913; hsa04914; hsa04915; hsa04916; hsa04918; hsa04919; hsa04921; hsa04922; hsa04923; hsa04924; hsa04925; hsa04926; hsa04927; hsa04928; hsa04934; hsa04961; hsa04962; hsa04970; hsa04971; hsa04976; hsa05012; hsa05020; hsa05030; hsa05031; hsa05032; hsa05034; hsa05110; hsa05146; hsa05163; hsa05165; hsa05166; hsa05169; hsa05200; hsa05203; hsa05205; hsa05414	2GU8; 3AGL; 3AGM; 3AMA; 3AMB; 3L9L; 3L9M; 3L9N; 3MVJ; 3NX8; 3OOG; 3OVV; 3OWP; 3OXT; 3P0M; 3POO; 3VQH; 4AE6; 4AE9; 4WB5; 4WB6; 4WB7; 4WB8	34.6%
3	PARP1	P09874	Poly [ADP-ribose] polymerase 1	hsa03410; hsa04064; hsa04210; hsa04217	1UK0; 1UK1; 1WOK; 2COK; 2CR9; 2CS2; 2DMJ; 2JVN; 2L30; 2L31; 2RCW; 2RD6; 2RIQ; 3GJW; 3GN7; 3L3L; 3L3M; 3OD8; 3ODA; 3ODC; 3ODE; 4AV1; 4DQY; 4GV7; 4HHY; 4HHZ; 4L6S; 4OPX; 4OQA; 4OQB; 4PJT; 4R5W; 4R6E; 4UND; 4UXB; 4XHU; 4ZZZ; 5A00	31.3%
4	ADORA2B	P29275	Adenosine receptor A2b	hsa04015; hsa04020; hsa04080; hsa04270; hsa05034	NA	31.2%
5	NQO1	P15559	NAD(P)H dehydrogenase [quinone] 1	hsa00130; hsa05200; hsa05225; hsa05418	1D4A; 1DXO; 1GG5; 1H66; 1H69; 1KBO; 1KBQ; 1QBG; 2F1O; 3JSX; 4CET; 4CF6	30.4%
6	MMP8	P22894	Neutrophil collagenase	NA	1A85; 1A86; 1BZS; 1I73; 1I76; 1JAN; 1JAO; 1JAP; 1JAQ; 1JH1; 1JJ9; 1KBC; 1MMB; 1MNC; 1ZP5; 1ZS0; 1ZVX; 2OY2; 2OY4; 3DNG; 3DPE; 3DPF; 3TT4; 4QKZ	29.1%
7	ACACB	O00763	Acetyl-CoA carboxylase 2	hsa00061; hsa00620; hsa00640; hsa01100; hsa04152; hsa04910; hsa04920; hsa04922; hsa04931	2DN8; 2HJW; 2KCC; 3FF6; 3GID; 3GLK; 3JRW; 3JRX; 3TDC; 4HQ6	29.1%
8	IFNG	P01579	Interferon gamma	hsa03050; hsa04060; hsa04066; hsa04217; hsa04350; hsa04380; hsa04612; hsa04630; hsa04650; hsa04657; hsa04658; hsa04659; hsa04660; hsa04940; hsa05132; hsa05140; hsa05142; hsa05143; hsa05144; hsa05145; hsa05146; hsa05152; hsa05162; hsa05164; hsa05168; hsa05169; hsa05200; hsa05321; hsa05322; hsa05323; hsa05330; hsa05332; hsa05418	1EKU; 1FG9; 1FYH; 1HIG; 3BES	28.6%
9	ADORA3	P0DMS8	Adenosine receptor A3	hsa04022; hsa04071; hsa04080	1OEA; 1R7N	28.2%
10	NT5E	P21589	5'-nucleotidase	hsa00230; hsa00240; hsa00760; hsa01100	4H1S; 4H1Y; 4H2B; 4H2F; 4H2G; 4H2I	27.9%
11	F8	P00451	Coagulation factor VIII	hsa04610	1CFG; 1D7P; 1FAC; 1IQD; 2R7E; 3CDZ; 3HNB; 3HNY; 3HOB; 3J2Q; 3J2S; 4BDV; 4KI5; 4PT6	27.9%
12	HTR2C	P28335	5-hydroxytryptamine receptor 2C	hsa04020; hsa04080; hsa04540; hsa04726; hsa04750	NA	27.2%
13	CHRNA2	Q15822	Neuronal acetylcholine receptor subunit alpha-2	hsa04080	NA	26.3%
14	PDE6G	P18545	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	hsa00230; hsa04744	3JWR	24.7%
15	PYGL	P06737	Glycogen phosphorylase, liver form	hsa00500; hsa01100; hsa04217; hsa04910; hsa04922; hsa04931	1EM6; 1EXV; 1FA9; 1FC0; 1L5Q; 1L5R; 1L5S; 1L7X; 1XOI; 2ATI; 2QLL; 2ZB2; 3CEH; 3CEJ; 3CEM; 3DD1; 3DDS; 3DDW	24.6%
16	HINT1	P49773	Histidine triad nucleotide-binding protein 1	NA	1AV5; 1KPA; 1KPB; 1KPC; 1KPE; 1KPF; 3TW2; 4EQE; 4EQG; 4EQH	24.4%
17	F10	P00742	Coagulation factor X	hsa04610	1C5M; 1EZQ; 1F0R; 1F0S; 1FAX; 1FJS; 1FXY; 1G2L; 1G2M; 1HCG; 1IOE; 1IQE; 1IQF; 1IQG; 1IQH; 1IQI; 1IQJ; 1IQK; 1IQL; 1IQM; 1IQN; 1KSN; 1LPG; 1LPK; 1LPZ; 1LQD; 1MQ5; 1MQ6; 1MSX; 1NFU; 1NFW; 1NFX; 1NFY; 1NL8; 1P0S; 1V3X; 1WU1; 1XKA; 1XKB; 1Z6E; 2BMG; 2BOH; 2BOK; 2BQ6; 2BQ7; 2BQW; 2CJI; 2D1J; 2EI6; 2EI7; 2EI8; 2FZZ; 2G00; 2GD4; 2H9E; 2J2U; 2J34; 2J38; 2J4I; 2J94; 2J95; 2JKH; 2P16; 2P3F; 2P3T; 2P3U; 2P93; 2P94; 2P95; 2PHB; 2PR3; 2Q1J; 2RA0; 2UWL; 2UWO; 2UWP; 2VH0; 2VH6; 2VVC; 2VVU; 2VVV; 2VWL; 2VWM; 2VWN; 2VWO; 2W26; 2W3I; 2W3K; 2WYG; 2WYJ; 2XBV; 2XBW; 2XBX; 2XBY; 2XC0; 2XC4; 2XC5; 2Y5F; 2Y5G; 2Y5H; 2Y7X; 2Y7Z; 2Y80; 2Y81; 2Y82; 3CEN; 3CS7; 3ENS; 3FFG; 3HPT; 3IIT; 3K9X; 3KL6; 3KQB; 3KQC; 3KQD; 3KQE; 3LIW; 3M36; 3M37; 3Q3K; 3SW2; 3TK5; 3TK6; 4A7I; 4BTI; 4BTT; 4BTU; 4Y6D; 4Y71; 4Y76; 4Y79; 4Y7A; 4Y7B	23.8%
18	PKIA	P61925	cAMP-dependent protein kinase inhibitor alpha	hsa05034	1CMK; 1JLU; 1Q8T; 1VEB; 1XH4; 1XH5; 1XH6; 1XH7; 1XH8; 1XH9; 1XHA; 1YDR; 2C1A; 2C1B; 2F7E; 2GNI; 2JDS; 2JDT; 2JDV; 2L1L; 2UVX; 2UVY; 2UVZ; 2UW0; 2UW3; 2UW4; 2UW5; 2UW6; 2UW7; 2UW8; 2VNW; 2VNY; 2VO0; 2VO3; 2VO6; 2VO7; 3AMA; 3AMB; 3L9L; 3L9M; 3L9N; 3MVJ; 3NX8; 3OOG; 3OVV; 3OWP; 3OXT; 3P0M; 3POO; 3VQH; 3WYG; 4AXA; 4IAC; 4IAD; 4IAF; 4IAI; 4IAK; 4IAY; 4IAZ; 4IB0; 4IB1; 4IB3; 4IE9; 4IJ9; 4O21; 4O22; 4WB5; 4WB6; 4WB7; 4WB8; 5DH9	23.6%
19	PGR	P06401	Progesterone receptor	hsa04114; hsa04914; hsa04915; hsa05224	1A28; 1E3K; 1SQN; 1SR7; 1ZUC; 2C7A; 2OVH; 2OVM; 2W8Y; 3D90; 3G8O; 3HQ5; 3KBA; 3ZR7; 3ZRA; 3ZRB; 4A2J; 4APU; 4OAR	23.1%
20	TLR9	Q9NR96	Toll-like receptor 9	hsa04620; hsa05142; hsa05143; hsa05144; hsa05152; hsa05162; hsa05168	NA	23.0%