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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q00975
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNA1B Q00975 Voltage-dependent N-type calcium channel subunit alpha-1B hsa04010; hsa04020; hsa04721; hsa04723; hsa04725; hsa04726; hsa04727; hsa04728; hsa04930; hsa05032; hsa05033 2LCM


11 known interactions (drugs) of input target (CACNA1B): Voltage-dependent N-type calcium channel subunit alpha-1B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb
3 Investigational SmallMoleculeDrug DB05885 Seletracetam Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb
5 Experimental;
Investigational		 SmallMoleculeDrug DB08838 Agmatine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB01202 Levetiracetam Thumb
7 Investigational SmallMoleculeDrug DB05950 Contulakin-G Thumb
8 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb
10 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb
11 Approved SmallMoleculeDrug DB00661 Verapamil Thumb


20 predicted interactions (drugs) of input target (CACNA1B): Voltage-dependent N-type calcium channel subunit alpha-1B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 62.1%
2 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 60.9%
3 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 60.9%
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 59.8%
5 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 59.1%
6 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 58.1%
7 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 57.9%
8 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 57.6%
9 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 55.9%
10 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 53.8%
11 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 53.7%
12 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 53.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb 53.5%
14 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 53.0%
15 Approved SmallMoleculeDrug DB00825 Menthol Thumb 52.9%
16 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb 47.9%
17 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 47.6%
18 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 47.5%
19 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 47.4%
20 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 46.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.