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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P43166
No. Gene UniProt ID Protein Name Pathway PDB
1 CA7 P43166 Carbonic anhydrase 7 hsa00910 3MDZ; 3ML5

6 known interactions (drugs) of input target (CA7): Carbonic anhydrase 7
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00703 Methazolamide Thumb
2 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb
3 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb
4 Approved;
SmallMoleculeDrug DB01144 Diclofenamide Thumb
5 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb
6 Approved;
Vet approved
SmallMoleculeDrug DB00819 Acetazolamide Thumb

20 predicted interactions (drugs) of input target (CA7): Carbonic anhydrase 7
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB01194 Brinzolamide Thumb 62.4%
2 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb 47.2%
3 Approved SmallMoleculeDrug DB00869 Dorzolamide Thumb 45.4%
4 Approved;
SmallMoleculeDrug DB00774 Hydroflumethiazide Thumb 44.5%
5 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 41.8%
6 Approved SmallMoleculeDrug DB00606 Cyclothiazide Thumb 41.3%
7 Approved SmallMoleculeDrug DB00232 Methyclothiazide Thumb 40.5%
8 Approved;
Vet approved
SmallMoleculeDrug DB01021 Trichlormethiazide Thumb 39.8%
9 Approved SmallMoleculeDrug DB09460 Sodium carbonate Thumb 39.8%
10 Approved;
SmallMoleculeDrug DB00391 Sulpiride Thumb 36.8%
11 Approved;
SmallMoleculeDrug DB01031 Ethinamate Thumb 34.6%
12 Approved SmallMoleculeDrug DB00436 Bendroflumethiazide Thumb 34.3%
13 Approved;
SmallMoleculeDrug DB00580 Valdecoxib Thumb 33.0%
14 Approved;
SmallMoleculeDrug DB00482 Celecoxib Thumb 32.0%
15 Experimental SmallMoleculeDrug DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE Thumb 30.4%
16 Experimental SmallMoleculeDrug DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE Thumb 30.2%
17 Investigational SmallMoleculeDrug DB12418 Saccharin Thumb 29.2%
18 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb 29.2%
19 Approved;
Vet approved
SmallMoleculeDrug DB00880 Chlorothiazide Thumb 29.1%
20 Approved SmallMoleculeDrug DB01325 Quinethazone Thumb 29.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.