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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08912
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRM5 P08912 Muscarinic acetylcholine receptor M5 hsa04020; hsa04080; hsa04725; hsa04810 NA

49 known interactions (drugs) of input target (CHRM5): Muscarinic acetylcholine receptor M5
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
2 Withdrawn SmallMoleculeDrug DB00767 Benzquinamide Thumb
3 Approved SmallMoleculeDrug DB01591 Solifenacin Thumb
4 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
5 Approved SmallMoleculeDrug DB00725 Homatropine Methylbromide Thumb
6 Approved;
SmallMoleculeDrug DB00622 Nicardipine Thumb
7 Approved;
SmallMoleculeDrug DB00342 Terfenadine Thumb
8 Approved;
SmallMoleculeDrug DB01239 Chlorprothixene Thumb
9 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
10 Approved SmallMoleculeDrug DB00785 Cryptenamine Thumb
11 Approved SmallMoleculeDrug DB00376 Trihexyphenidyl Thumb
12 Investigational SmallMoleculeDrug DB05752 ALKS 27 Thumb
13 Approved;
SmallMoleculeDrug DB00496 Darifenacin Thumb
14 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
15 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
16 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
17 Approved SmallMoleculeDrug DB09076 Umeclidinium Thumb
18 Approved SmallMoleculeDrug DB11235 Thonzylamine Thumb
19 Approved SmallMoleculeDrug DB01409 Tiotropium Thumb
20 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb
21 Approved SmallMoleculeDrug DB06702 Fesoterodine Thumb
22 Approved;
SmallMoleculeDrug DB01238 Aripiprazole Thumb
23 Approved SmallMoleculeDrug DB11181 Homatropine Thumb
24 Approved;
SmallMoleculeDrug DB00747 Scopolamine Thumb
25 Approved;
SmallMoleculeDrug DB01151 Desipramine Thumb
26 Approved SmallMoleculeDrug DB00483 Gallamine Triethiodide Thumb
27 Approved;
SmallMoleculeDrug DB12278 Propiverine Thumb
28 Approved;
SmallMoleculeDrug DB00555 Lamotrigine Thumb
29 Approved;
SmallMoleculeDrug DB01069 Promethazine Thumb
30 Approved;
SmallMoleculeDrug DB00568 Cinnarizine Thumb
31 Approved;
Vet approved
SmallMoleculeDrug DB00572 Atropine Thumb
32 Approved SmallMoleculeDrug DB00835 Brompheniramine Thumb
33 Approved;
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
34 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
35 Approved;
Vet approved
SmallMoleculeDrug DB00420 Promazine Thumb
36 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
37 Approved SmallMoleculeDrug DB00340 Metixene Thumb
38 Approved;
SmallMoleculeDrug DB00715 Paroxetine Thumb
39 Approved SmallMoleculeDrug DB08897 Aclidinium Thumb
40 Approved;
SmallMoleculeDrug DB01142 Doxepin Thumb
41 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
42 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
43 Approved;
SmallMoleculeDrug DB01036 Tolterodine Thumb
44 Approved;
SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
45 Approved;
SmallMoleculeDrug DB00334 Olanzapine Thumb
46 Approved;
SmallMoleculeDrug DB00934 Maprotiline Thumb
47 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
48 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
49 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb

20 predicted interactions (drugs) of input target (CHRM5): Muscarinic acetylcholine receptor M5
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb 86.0%
2 Approved SmallMoleculeDrug DB06787 Hexocyclium Thumb 84.6%
3 Approved;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb 84.2%
4 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 83.8%
5 Approved SmallMoleculeDrug DB00387 Procyclidine Thumb 83.3%
6 Approved SmallMoleculeDrug DB00411 Carbachol Thumb 83.0%
7 Approved;
Vet approved
SmallMoleculeDrug DB01625 Isopropamide Thumb 82.9%
8 Approved SmallMoleculeDrug DB03128 Acetylcholine Thumb 82.8%
9 Approved;
Vet approved
SmallMoleculeDrug DB00508 Triflupromazine Thumb 82.1%
10 Approved;
SmallMoleculeDrug DB01085 Pilocarpine Thumb 81.6%
11 Approved SmallMoleculeDrug DB01019 Bethanechol Thumb 80.9%
12 Approved SmallMoleculeDrug DB00424 Hyoscyamine Thumb 80.9%
13 Approved;
SmallMoleculeDrug DB00809 Tropicamide Thumb 80.7%
14 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 79.7%
15 Approved;
SmallMoleculeDrug DB00907 Cocaine Thumb 79.0%
16 Approved;
SmallMoleculeDrug DB09262 Imidafenacin Thumb 78.7%
17 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 78.2%
18 Approved;
SmallMoleculeDrug DB01175 Escitalopram Thumb 77.2%
19 Approved;
SmallMoleculeDrug DB01062 Oxybutynin Thumb 76.6%
20 Approved SmallMoleculeDrug DB00383 Oxyphencyclimine Thumb 76.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.