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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P55017
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC12A3 P55017 Solute carrier family 12 member 3 NA NA

10 known interactions (drugs) of input target (SLC12A3): Solute carrier family 12 member 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00436 Bendroflumethiazide Thumb
2 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb
3 Approved SmallMoleculeDrug DB00524 Metolazone Thumb
4 Approved;
Vet approved
SmallMoleculeDrug DB00999 Hydrochlorothiazide Thumb
5 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb
6 Approved SmallMoleculeDrug DB01325 Quinethazone Thumb
7 Approved;
Vet approved
SmallMoleculeDrug DB01021 Trichlormethiazide Thumb
8 Approved SmallMoleculeDrug DB01324 Polythiazide Thumb
9 Approved SmallMoleculeDrug DB00808 Indapamide Thumb
10 Approved;
Vet approved
SmallMoleculeDrug DB00880 Chlorothiazide Thumb

20 predicted interactions (drugs) of input target (SLC12A3): Solute carrier family 12 member 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00774 Hydroflumethiazide Thumb 60.4%
2 Approved SmallMoleculeDrug DB09460 Sodium carbonate Thumb 47.6%
3 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb 42.6%
4 Approved;
SmallMoleculeDrug DB01031 Ethinamate Thumb 41.8%
5 Approved SmallMoleculeDrug DB00869 Dorzolamide Thumb 41.7%
6 Approved;
SmallMoleculeDrug DB01144 Diclofenamide Thumb 40.5%
7 Approved;
Vet approved
SmallMoleculeDrug DB00819 Acetazolamide Thumb 39.3%
8 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 39.3%
9 Experimental SmallMoleculeDrug DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE Thumb 39.1%
10 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb 38.6%
11 Approved SmallMoleculeDrug DB00232 Methyclothiazide Thumb 38.3%
12 Experimental SmallMoleculeDrug DB08156 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID Thumb 38.0%
13 Experimental SmallMoleculeDrug DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE Thumb 38.0%
14 Approved;
Vet approved
SmallMoleculeDrug DB09472 Sodium sulfate Thumb 37.5%
15 Approved SmallMoleculeDrug DB00703 Methazolamide Thumb 37.5%
16 Approved;
Vet approved
SmallMoleculeDrug DB00423 Methocarbamol Thumb 36.8%
17 Investigational SmallMoleculeDrug DB02292 Irosustat Thumb 36.6%
18 Approved SmallMoleculeDrug DB01194 Brinzolamide Thumb 35.2%
19 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 35.0%
20 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 33.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.