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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P28335
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR2C P28335 5-hydroxytryptamine receptor 2C hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA


72 known interactions (drugs) of input target (HTR2C): 5-hydroxytryptamine receptor 2C
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00574 Fenfluramine Thumb
2 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
3 Investigational SmallMoleculeDrug DB04884 Dapoxetine Thumb
4 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb
5 Investigational SmallMoleculeDrug DB12163 Sarpogrelate Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
8 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
9 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
10 Experimental;
Illicit		 SmallMoleculeDrug DB01537 4-Bromo-2,5-dimethoxyphenethylamine Thumb
11 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb
13 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
14 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
15 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
16 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb
17 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
18 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
20 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
21 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
22 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
23 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
24 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01242 Clomipramine Thumb
25 Approved SmallMoleculeDrug DB00805 Minaprine Thumb
26 Investigational SmallMoleculeDrug DB06446 Dotarizine Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
28 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
30 Approved;
Vet approved		 SmallMoleculeDrug DB00472 Fluoxetine Thumb
31 Approved SmallMoleculeDrug DB00215 Citalopram Thumb
32 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
33 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
35 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb
36 Approved SmallMoleculeDrug DB04871 Lorcaserin Thumb
37 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
38 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
39 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb
40 Approved SmallMoleculeDrug DB00623 Fluphenazine Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
42 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
43 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01191 Dexfenfluramine Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb
45 Investigational SmallMoleculeDrug DB06512 Deramciclane Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
47 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
49 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
50 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
51 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
52 Experimental SmallMoleculeDrug DB13940 2,5-Dimethoxy-4-ethylthioamphetamine Thumb
53 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
54 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
55 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
56 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
57 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb
58 Investigational SmallMoleculeDrug DB12110 m-Chlorophenylpiperazine Thumb
59 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
60 Approved;
Investigational		 SmallMoleculeDrug DB06594 Agomelatine Thumb
61 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
62 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
63 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01079 Tegaserod Thumb
64 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
65 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
66 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
67 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
68 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb
69 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
70 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
71 Approved;
Investigational		 SmallMoleculeDrug DB09014 Captodiame Thumb
72 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb


20 predicted interactions (drugs) of input target (HTR2C): 5-hydroxytryptamine receptor 2C
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 92.9%
2 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 90.7%
3 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb 87.4%
4 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb 84.8%
5 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb 84.5%
6 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb 83.0%
7 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb 82.7%
8 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb 82.0%
9 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 81.5%
10 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb 80.4%
11 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 80.3%
12 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 80.1%
13 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb 79.4%
14 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00875 Flupentixol Thumb 78.1%
15 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 78.0%
16 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb 76.8%
17 Approved;
Withdrawn		 SmallMoleculeDrug DB00679 Thioridazine Thumb 76.7%
18 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb 76.3%
19 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb 76.0%
20 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb 75.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.