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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q09470
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNA1 Q09470 Potassium voltage-gated channel subfamily A member 1 NA 2AFL


10 known interactions (drugs) of input target (KCNA1): Potassium voltage-gated channel subfamily A member 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
2 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
3 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb
4 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb
5 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb
6 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb
7 Approved SmallMoleculeDrug DB11640 Amifampridine Thumb
8 Approved SmallMoleculeDrug DB01189 Desflurane Thumb
9 Experimental;
Investigational		 SmallMoleculeDrug DB08837 Tetraethylammonium Thumb
10 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb


20 predicted interactions (drugs) of input target (KCNA1): Potassium voltage-gated channel subfamily A member 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 73.6%
2 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 68.4%
3 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 68.0%
4 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 64.2%
5 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 59.3%
6 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 54.8%
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb 53.0%
8 Approved;
Illicit		 SmallMoleculeDrug DB00683 Midazolam Thumb 51.2%
9 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb 50.7%
10 Approved;
Investigational		 SmallMoleculeDrug DB11901 Apalutamide Thumb 50.6%
11 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 50.5%
12 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb 48.4%
13 Approved;
Illicit		 SmallMoleculeDrug DB00628 Clorazepate Thumb 48.3%
14 Approved;
Illicit		 SmallMoleculeDrug DB01588 Prazepam Thumb 47.2%
15 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB01107 Methyprylon Thumb 46.8%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb 46.7%
17 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 46.6%
18 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 46.0%
19 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb 45.9%
20 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb 45.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.