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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35372
No. Gene UniProt ID Protein Name Pathway PDB
1 OPRM1 P35372 Mu-type opioid receptor hsa04080; hsa04915; hsa05032 NA


61 known interactions (drugs) of input target (OPRM1): Mu-type opioid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00497 Oxycodone Thumb
2 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
3 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
4 Approved;
Illicit		 SmallMoleculeDrug DB00318 Codeine Thumb
5 Investigational SmallMoleculeDrug DB05509 LI-301 Thumb
6 Investigational SmallMoleculeDrug DB14146 Loxicodegol Thumb
7 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01452 Heroin Thumb
8 Approved SmallMoleculeDrug DB00854 Levorphanol Thumb
9 Approved;
Illicit		 SmallMoleculeDrug DB09209 Pholcodine Thumb
10 Approved;
Illicit		 SmallMoleculeDrug DB01466 Ethylmorphine Thumb
11 Approved;
Illicit		 SmallMoleculeDrug DB11130 Opium Thumb
12 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
13 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00921 Buprenorphine Thumb
14 Illicit;
Vet approved		 SmallMoleculeDrug DB01548 Diprenorphine Thumb
15 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb
16 Experimental;
Illicit		 SmallMoleculeDrug DB01439 3-Methylthiofentanyl Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB01227 Levomethadyl Acetate Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB06738 Ketobemidone Thumb
19 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
20 Approved SmallMoleculeDrug DB00904 Ondansetron Thumb
21 Approved SmallMoleculeDrug DB00333 Methadone Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB11186 Pentoxyverine Thumb
23 Illicit;
Vet approved		 SmallMoleculeDrug DB01497 Etorphine Thumb
24 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
25 Experimental;
Illicit		 SmallMoleculeDrug DB01565 Dihydromorphine Thumb
26 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
27 Experimental;
Illicit		 SmallMoleculeDrug DB01444 Dimethylthiambutene Thumb
28 Approved;
Illicit		 SmallMoleculeDrug DB01433 Methadyl Acetate Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB09272 Eluxadoline Thumb
30 Illicit SmallMoleculeDrug DB01571 3-Methylfentanyl Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB11691 Naldemedine Thumb
33 Investigational SmallMoleculeDrug DB05046 V1003 Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB00295 Morphine Thumb
35 Approved;
Illicit		 SmallMoleculeDrug DB00956 Hydrocodone Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB00708 Sufentanil Thumb
37 Approved;
Illicit		 SmallMoleculeDrug DB00327 Hydromorphone Thumb
38 Approved;
Vet approved		 SmallMoleculeDrug DB00652 Pentazocine Thumb
39 Approved;
Illicit		 SmallMoleculeDrug DB01081 Diphenoxylate Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
41 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01192 Oxymorphone Thumb
42 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
43 Approved;
Investigational		 SmallMoleculeDrug DB09289 Tianeptine Thumb
44 Approved;
Illicit;
Vet approved		 SmallMoleculeDrug DB00611 Butorphanol Thumb
45 Approved;
Vet approved		 SmallMoleculeDrug DB01183 Naloxone Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB01209 Dezocine Thumb
47 Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB01535 Carfentanil Thumb
48 Approved;
Illicit		 SmallMoleculeDrug DB00802 Alfentanil Thumb
49 Approved SmallMoleculeDrug DB00836 Loperamide Thumb
50 Approved;
Investigational		 SmallMoleculeDrug DB06274 Alvimopan Thumb
51 Approved SmallMoleculeDrug DB00504 Levallorphan Thumb
52 Approved SmallMoleculeDrug DB06800 Methylnaltrexone Thumb
53 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06230 Nalmefene Thumb
54 Approved SmallMoleculeDrug DB00844 Nalbuphine Thumb
55 Approved SmallMoleculeDrug DB00899 Remifentanil Thumb
56 Approved;
Illicit		 SmallMoleculeDrug DB00913 Anileridine Thumb
57 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00813 Fentanyl Thumb
58 Approved SmallMoleculeDrug DB06204 Tapentadol Thumb
59 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00647 Dextropropoxyphene Thumb
60 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00704 Naltrexone Thumb
61 Approved SmallMoleculeDrug DB09049 Naloxegol Thumb


20 predicted interactions (drugs) of input target (OPRM1): Mu-type opioid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB05050 ADL5859 Thumb 75.0%
2 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 70.9%
3 Investigational SmallMoleculeDrug DB05155 CR665 Thumb 63.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 62.6%
5 Investigational SmallMoleculeDrug DB05104 Asimadoline Thumb 62.0%
6 Investigational SmallMoleculeDrug DB05443 ADL 10-0101 Thumb 59.6%
7 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb 59.2%
8 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 57.7%
9 Approved SmallMoleculeDrug DB00825 Menthol Thumb 56.5%
10 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 52.7%
11 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 45.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 43.7%
13 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb 41.7%
14 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 41.3%
15 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb 40.8%
16 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01079 Tegaserod Thumb 40.0%
17 Approved;
Investigational		 SmallMoleculeDrug DB01233 Metoclopramide Thumb 39.8%
18 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 39.0%
19 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 38.4%
20 Investigational SmallMoleculeDrug DB05642 DDP-225 Thumb 38.4%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.