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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9P0X4
No. Gene UniProt ID Protein Name Pathway PDB
1 CACNA1I Q9P0X4 Voltage-dependent T-type calcium channel subunit alpha-1I hsa04010; hsa04020; hsa04713; hsa04925; hsa04927; hsa04934 NA


17 known interactions (drugs) of input target (CACNA1I): Voltage-dependent T-type calcium channel subunit alpha-1I
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
3 Approved SmallMoleculeDrug DB00617 Paramethadione Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb
6 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB09235 Efonidipine Thumb
8 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb
9 Approved SmallMoleculeDrug DB06152 Nylidrin Thumb
10 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
11 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb
12 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
16 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb
17 Approved SmallMoleculeDrug DB00661 Verapamil Thumb


20 predicted interactions (drugs) of input target (CACNA1I): Voltage-dependent T-type calcium channel subunit alpha-1I
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00825 Menthol Thumb 68.1%
2 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 65.5%
3 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 62.8%
4 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 61.7%
5 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 60.8%
6 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 56.6%
7 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 56.0%
8 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 54.5%
9 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 54.4%
10 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb 53.4%
11 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 52.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 50.8%
13 Approved;
Investigational		 SmallMoleculeDrug DB04920 Clevidipine Thumb 47.8%
14 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 47.5%
15 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 46.9%
16 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb 46.8%
17 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 45.8%
18 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 45.1%
19 Approved SmallMoleculeDrug DB00347 Trimethadione Thumb 44.0%
20 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb 43.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.