Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics


Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P06401
No. Gene UniProt ID Protein Name Pathway PDB
1 PGR P06401 Progesterone receptor hsa04114; hsa04914; hsa04915; hsa05224 1A28; 1E3K; 1SQN; 1SR7; 1ZUC; 2C7A; 2OVH; 2OVM; 2W8Y; 3D90; 3G8O; 3HQ5; 3KBA; 3ZR7; 3ZRA; 3ZRB; 4A2J; 4APU; 4OAR

35 known interactions (drugs) of input target (PGR): Progesterone receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Investigational SmallMoleculeDrug DB04787 Tanaproget Thumb
2 Approved;
SmallMoleculeDrug DB00431 Lindane Thumb
3 Approved SmallMoleculeDrug DB01428 Oxybenzone Thumb
4 Approved SmallMoleculeDrug DB13857 Demegestone Thumb
5 Approved SmallMoleculeDrug DB09389 Norgestrel Thumb
6 Approved SmallMoleculeDrug DB09124 Medrogestone Thumb
7 Approved;
SmallMoleculeDrug DB00294 Etonogestrel Thumb
8 Approved SmallMoleculeDrug DB00717 Norethisterone Thumb
9 Approved SmallMoleculeDrug DB01431 Allylestrenol Thumb
10 Approved;
SmallMoleculeDrug DB00367 Levonorgestrel Thumb
11 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb
12 Approved;
SmallMoleculeDrug DB00957 Norgestimate Thumb
13 Approved;
SmallMoleculeDrug DB06713 Norelgestromin Thumb
14 Investigational SmallMoleculeDrug DB05253 Proellex Thumb
15 Approved SmallMoleculeDrug DB00304 Desogestrel Thumb
16 Approved;
Vet approved
SmallMoleculeDrug DB00764 Mometasone Thumb
17 Approved SmallMoleculeDrug DB01406 Danazol Thumb
18 Approved SmallMoleculeDrug DB11619 Gestrinone Thumb
19 Approved SmallMoleculeDrug DB09123 Dienogest Thumb
20 Approved SmallMoleculeDrug DB00823 Ethynodiol diacetate Thumb
21 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
22 Approved;
Vet approved
SmallMoleculeDrug DB00396 Progesterone Thumb
23 Approved;
SmallMoleculeDrug DB11064 Homosalate Thumb
24 Approved;
SmallMoleculeDrug DB00834 Mifepristone Thumb
25 Investigational SmallMoleculeDrug DB06680 Asoprisnil Thumb
26 Approved;
SmallMoleculeDrug DB00378 Dydrogesterone Thumb
27 Approved;
SmallMoleculeDrug DB06789 Hydroxyprogesterone caproate Thumb
28 Approved;
SmallMoleculeDrug DB00603 Medroxyprogesterone acetate Thumb
29 Approved;
Vet approved
SmallMoleculeDrug DB00351 Megestrol acetate Thumb
30 Approved SmallMoleculeDrug DB01395 Drospirenone Thumb
31 Approved SmallMoleculeDrug DB08867 Ulipristal Thumb
32 Approved SmallMoleculeDrug DB00588 Fluticasone propionate Thumb
33 Experimental SmallMoleculeDrug DB02998 Methyltrienolone Thumb
34 Approved SmallMoleculeDrug DB00648 Mitotane Thumb
35 Approved SmallMoleculeDrug DB11219 Enzacamene Thumb

20 predicted interactions (drugs) of input target (PGR): Progesterone receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB09130 Copper Thumb 72.9%
2 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 60.8%
3 Approved;
SmallMoleculeDrug DB01185 Fluoxymesterone Thumb 55.0%
4 Illicit;
SmallMoleculeDrug DB02901 Stanolone Thumb 52.4%
5 Experimental;
SmallMoleculeDrug DB04216 Quercetin Thumb 50.0%
6 Approved SmallMoleculeDrug DB13944 Testosterone enanthate Thumb 49.3%
7 Approved SmallMoleculeDrug DB13943 Testosterone cypionate Thumb 46.8%
8 Approved SmallMoleculeDrug DB09086 Eugenol Thumb 44.9%
9 Experimental SmallMoleculeDrug DB02757 Pyrazole Thumb 44.6%
10 Approved;
SmallMoleculeDrug DB13946 Testosterone undecanoate Thumb 44.4%
11 Approved;
SmallMoleculeDrug DB00624 Testosterone Thumb 43.9%
12 Approved;
SmallMoleculeDrug DB00687 Fludrocortisone Thumb 42.4%
13 Approved SmallMoleculeDrug DB06710 Methyltestosterone Thumb 42.1%
14 Approved SmallMoleculeDrug DB00655 Estrone Thumb 41.9%
15 Approved SmallMoleculeDrug DB00841 Dobutamine Thumb 41.8%
16 Experimental SmallMoleculeDrug DB13951 Stanolone acetate Thumb 41.5%
17 Approved;
SmallMoleculeDrug DB01708 Prasterone Thumb 40.2%
18 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 40.2%
19 Approved;
SmallMoleculeDrug DB04824 Phenolphthalein Thumb 39.7%
20 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 39.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.