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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P43681
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNA4 P43681 Neuronal acetylcholine receptor subunit alpha-4 hsa04080; hsa04725; hsa05033 2GVT; 2LLY


40 known interactions (drugs) of input target (CHRNA4): Neuronal acetylcholine receptor subunit alpha-4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
2 Experimental;
Illicit		 SmallMoleculeDrug DB01496 Barbituric acid derivative Thumb
3 Approved;
Illicit		 SmallMoleculeDrug DB01352 Aprobarbital Thumb
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13955 Estradiol dienanthate Thumb
5 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb
6 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb
8 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
9 Approved SmallMoleculeDrug DB00184 Nicotine Thumb
10 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13956 Estradiol valerate Thumb
12 Illicit SmallMoleculeDrug DB01483 Barbital Thumb
13 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13954 Estradiol cypionate Thumb
15 Approved SmallMoleculeDrug DB00915 Amantadine Thumb
16 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb
17 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb
18 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb
19 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb
20 Approved;
Investigational		 SmallMoleculeDrug DB00981 Physostigmine Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB00564 Carbamazepine Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB01273 Varenicline Thumb
23 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb
24 Approved SmallMoleculeDrug DB00674 Galantamine Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB00747 Scopolamine Thumb
26 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb
27 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb
28 Approved SmallMoleculeDrug DB01245 Decamethonium Thumb
29 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13952 Estradiol acetate Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB09028 Cytisine Thumb
31 Experimental SmallMoleculeDrug DB07720 Epibatidine Thumb
32 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
33 Investigational SmallMoleculeDrug DB05458 Pozanicline Thumb
34 Approved;
Illicit		 SmallMoleculeDrug DB01353 Butethal Thumb
35 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00783 Estradiol Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB01174 Phenobarbital Thumb
37 Approved;
Investigational		 SmallMoleculeDrug DB00657 Mecamylamine Thumb
38 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13953 Estradiol benzoate Thumb
39 Investigational SmallMoleculeDrug DB05740 RPI-78M Thumb
40 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb


20 predicted interactions (drugs) of input target (CHRNA4): Neuronal acetylcholine receptor subunit alpha-4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 80.7%
2 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 65.8%
3 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb 65.4%
4 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb 64.5%
5 Approved;
Illicit		 SmallMoleculeDrug DB00349 Clobazam Thumb 64.5%
6 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb 64.3%
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb 64.2%
8 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb 62.9%
9 Investigational SmallMoleculeDrug DB06579 Adipiplon Thumb 62.8%
10 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb 62.7%
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 62.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 62.3%
13 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb 61.9%
14 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb 60.1%
15 Approved;
Illicit		 SmallMoleculeDrug DB01544 Flunitrazepam Thumb 59.9%
16 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 59.7%
17 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb 59.7%
18 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 58.9%
19 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 58.8%
20 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00404 Alprazolam Thumb 58.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.