QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O15554
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNN4 O15554 Intermediate conductance calcium-activated potassium channel protein 4 hsa04911; hsa04970; hsa04974 NA


7 known interactions (drugs) of input target (KCNN4): Intermediate conductance calcium-activated potassium channel protein 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00721 Procaine Thumb
2 Approved SmallMoleculeDrug DB00468 Quinine Thumb
3 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb
4 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
5 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb
6 Approved;
Vet approved		 SmallMoleculeDrug DB00257 Clotrimazole Thumb
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb


20 predicted interactions (drugs) of input target (KCNN4): Intermediate conductance calcium-activated potassium channel protein 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 48.5%
2 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 47.4%
3 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 45.7%
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb 44.7%
5 Approved SmallMoleculeDrug DB01189 Desflurane Thumb 43.1%
6 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 41.8%
7 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 41.5%
8 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 40.4%
9 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb 38.7%
10 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb 36.9%
11 Approved;
Illicit		 SmallMoleculeDrug DB01567 Fludiazepam Thumb 36.3%
12 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 36.0%
13 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb 35.7%
14 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb 34.9%
15 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb 34.1%
16 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 33.8%
17 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb 33.7%
18 Approved SmallMoleculeDrug DB09166 Etizolam Thumb 32.5%
19 Approved SmallMoleculeDrug DB00395 Carisoprodol Thumb 32.1%
20 Approved SmallMoleculeDrug DB01587 Ketazolam Thumb 31.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.