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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q99712
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ15 Q99712 ATP-sensitive inward rectifier potassium channel 15 hsa04971 NA

2 known interactions (drugs) of input target (KCNJ15): ATP-sensitive inward rectifier potassium channel 15
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB11148 Butamben Thumb
2 Approved;
Vet approved
SmallMoleculeDrug DB01392 Yohimbine Thumb

20 predicted interactions (drugs) of input target (KCNJ15): ATP-sensitive inward rectifier potassium channel 15
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 31.5%
2 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 31.0%
3 Approved;
SmallMoleculeDrug DB00922 Levosimendan Thumb 27.8%
4 Approved;
SmallMoleculeDrug DB13746 Bioallethrin Thumb 25.0%
5 Approved;
Vet approved
SmallMoleculeDrug DB01154 Thiamylal Thumb 24.9%
6 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 24.7%
7 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb 24.5%
8 Experimental;
BiotechDrug DB14009 Medical Cannabis Thumb 23.5%
9 Approved;
SmallMoleculeDrug DB14011 Nabiximols Thumb 22.7%
10 Approved;
SmallMoleculeDrug DB09061 Cannabidiol Thumb 22.6%
11 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 22.1%
12 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 21.4%
13 Approved SmallMoleculeDrug DB01016 Glyburide Thumb 20.8%
14 Approved;
SmallMoleculeDrug DB00568 Cinnarizine Thumb 20.7%
15 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 20.6%
16 Approved;
SmallMoleculeDrug DB01251 Gliquidone Thumb 20.5%
17 Approved;
SmallMoleculeDrug DB09238 Manidipine Thumb 20.4%
18 Approved;
SmallMoleculeDrug DB00914 Phenformin Thumb 20.0%
19 Approved;
SmallMoleculeDrug DB00839 Tolazamide Thumb 18.9%
20 Investigational;
SmallMoleculeDrug DB01388 Mibefradil Thumb 18.9%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.