QuartataWeb 1.0

34 known interactions (drugs) of input target (PLAU): Urokinase-type plasminogen activator

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Approved; Investigational; Withdrawn	BiotechDrug	DB00013	Urokinase	NA
2	Experimental	SmallMoleculeDrug	DB07129	(2R)-1-(2,6-dimethylphenoxy)propan-2-amine	[H][C@](C)(N)COC1=C(C)C=CC=C1C
3	Experimental	SmallMoleculeDrug	DB01977	6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine	NC(=N)C1=CC=C2C=C(C=CC2=C1)C(=O)NC1=CC=CC=C1
4	Experimental	SmallMoleculeDrug	DB02526	CRA_10655	NC(=[NH2+])C1=CC=C2NC(=NC2=C1)C1=CC=CC(OC2CCCC2)=C1[O-]
5	Experimental	SmallMoleculeDrug	DB07625	4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide	CCOC1=CC=C(OCC)C(NC(=O)C2=CC(C)=C(OCCN)C(C)=C2)=C1
6	Experimental	SmallMoleculeDrug	DB07076	6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE	NC(=N)C1=CC2=CC=C(C=C2C=C1)C(=O)NC1=CC=CC(OC2CCCC2)=C1
7	Experimental	SmallMoleculeDrug	DB02473	6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine	CC(C)C1=NCCC2=C1C=C(NC(=O)C1=CC=C3C=C(C=CC3=C1)C(N)=N)C=C2
8	Experimental	SmallMoleculeDrug	DB02705	6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine	[H][C@]1(NCCC2=C1C=C(NC(=O)C1=CC=C3C=C(C=CC3=C1)C(N)=N)C=C2)C(C)C
9	Experimental	SmallMoleculeDrug	DB02287	2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine	NC(=[NH2+])C1=CC2=C(C=C1)N=C(N2)C1=CC=CC=C1O
10	Experimental	SmallMoleculeDrug	DB06856	6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE	[H][C@]1(C)CCCC[C@]1([H])OC1=C(O)C(=CC=C1)C1=CC2=CC(C(N)=N)=C(F)C=C2N1
11	Experimental	SmallMoleculeDrug	DB03159	CRA_8696	NC(=[NH2+])C1=CC=C2NC(=CC2=C1)C1=CC=CC(=C1[O-])C1=CC=CC=C1
12	Experimental	SmallMoleculeDrug	DB03782	N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea	[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)NC(=O)NCC1=CC=C(NC(N)=N)C=C1
13	Experimental	SmallMoleculeDrug	DB01725	2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide	NC(=N)C1=CC2=C(NC(=N2)C2=CC=CC(C3=CC=CC=C3)=C2O)C=C1
14	Experimental	SmallMoleculeDrug	DB03136	4-Iodobenzo[B]Thiophene-2-Carboxamidine	NC(=[NH2+])C1=CC2=C(S1)C=CC=C2I
15	Experimental	SmallMoleculeDrug	DB03082	6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide	NCC1=CC=C(NC(=O)C2=CC(NC3=NC=CC=N3)=C3C=C(C=CC3=C2)C(N)=N)C=C1
16	Experimental	SmallMoleculeDrug	DB08697	4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide	CC1=CC(=CC(C)=C1OCCN)C(=O)NC1=CC(Cl)=CC(=C1)N1CCCCC1
17	Experimental	SmallMoleculeDrug	DB04059	8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide	NC(=N)C1=CC2=C(C=CC=C2NC2=NC=CC=N2)C=C1
18	Approved	SmallMoleculeDrug	DB00594	Amiloride	NC(N)=NC(=O)C1=C(N)N=C(N)C(Cl)=N1
19	Experimental	SmallMoleculeDrug	DB03127	Benzamidine	NC(=[NH2+])C1=CC=CC=C1
20	Experimental	SmallMoleculeDrug	DB06855	6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine	CC(C)COC1=C(O)C(=CC=C1)C1=NC2=CC(C(N)=N)=C(F)C=C2N1
21	Experimental	SmallMoleculeDrug	DB01905	2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine	COC1=CC=C(O)C(=C1)C1=NC2=C(N1)C=CC(=C2)C(N)=[NH2+]
22	Experimental	SmallMoleculeDrug	DB03865	6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine	NC(=[NH2+])C1=CC2=C(NC(=C2)C2=CC=CC(=C2O)C2=CC=CC=C2)C=C1Cl
23	Experimental	SmallMoleculeDrug	DB06857	N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE	CC1=CC(I)=C(O)C(=C1)C(=O)NC1=CC(Cl)=C(C=C1)C(N)=N
24	Experimental	SmallMoleculeDrug	DB03729	2-Amino-5-Hydroxy-Benzimidazole	OC1=CC2=C(NC(=N)N2)C=C1
25	Experimental	SmallMoleculeDrug	DB02398	6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine	NCC1=CC=C(NC(=O)C2=CC=C3C=C(C=CC3=C2)C(N)=N)C=C1
26	Experimental	SmallMoleculeDrug	DB03476	Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine	[H][C@]1(C[C@@]1([H])C1=CC2=CC=C(C=C2C=C1)C(N)=N)C1=CC=CC=C1
27	Experimental	SmallMoleculeDrug	DB03046	7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide	COC1=CC=C2C=CC(=CC2=C1C1=CN(N=C1)S(C)(=O)=O)C(N)=N
28	Experimental	SmallMoleculeDrug	DB03876	Thieno[2,3-B]Pyridine-2-Carboxamidine	NC(=[NH2+])C1=CC2=C(S1)N=CC=C2
29	Experimental	SmallMoleculeDrug	DB07626	4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide	CCOC1=C(NC(=O)C2=CC(C)=C(OCCN)C(C)=C2)C=C(C=C1Cl)N1CCCCC1
30	Experimental	SmallMoleculeDrug	DB02551	6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine	[H][C@]1(CC)CNCC2=C1C=C(NC(=O)C1=CC=C3C=C(C=CC3=C1)C(N)=N)C=C2
31	Experimental	SmallMoleculeDrug	DB07122	1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine	NC(=N)NC1=CC=C(CC(=O)C2=CC=CC=C2)C=C1
32	Investigational	BiotechDrug	DB05254	Fibrinolysin	NA
33	Experimental	SmallMoleculeDrug	DB08072	4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE	CC(C)OC1=CC(NC(=O)C2=CC(Cl)=C(OCCN)C(Cl)=C2)=CC=C1
34	Experimental	SmallMoleculeDrug	DB04172	[2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine	[H][C@@](CC1=CC(=CC=C1)C(N)=N)(NS(=O)(=O)C1=C(C=C(C=C1C(C)C)C(C)C)C(C)C)C(=O)N1CCN(CC1)C(=O)CCN

20 predicted interactions (drugs) of input target (PLAU): Urokinase-type plasminogen activator

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Approved; Investigational	SmallMoleculeDrug	DB12010	Fostamatinib	COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC	39.4%
2	Experimental	SmallMoleculeDrug	DB02467	L-methionine (S)-S-oxide	[H]C([H])([H])[S@](=O)C([H])([H])C([H])([H])[C@@]([H])(C([O-])=O)[N+]([H])([H])[H]	38.5%
3	Approved; Investigational; Withdrawn	BiotechDrug	DB06692	Aprotinin	NA	38.4%
4	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB00155	L-Citrulline	N[C@@H](CCCNC(N)=O)C(O)=O	38.0%
5	Experimental	SmallMoleculeDrug	DB03832	3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium	[H][C@@](CC(O)=O)(C[N+](C)(C)C)OC(=O)CCCCCCC	34.2%
6	Approved; Investigational	SmallMoleculeDrug	DB01593	Zinc	[Zn]	33.3%
7	Approved	SmallMoleculeDrug	DB00384	Triamterene	NC1=NC(N)=C2N=C(C(N)=NC2=N1)C1=CC=CC=C1	32.3%
8	Experimental	SmallMoleculeDrug	DB03608	Diminazene	NC(=N)C1=CC=C(N\N=N\C2=CC=C(C=C2)C(N)=N)C=C1	31.1%
9	Experimental	SmallMoleculeDrug	DB06840	diethyl [(1R)-1,5-diaminopentyl]boronate	[H][C@](N)(CCCCN)B(OCC)OCC	30.8%
10	Experimental	SmallMoleculeDrug	DB02464	Benzylamine	NCC1=CC=CC=C1	30.0%
11	Experimental	SmallMoleculeDrug	DB04107	[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester	CCOC(=O)CO\N=C(\C1=CC=CC=N1)C1(CC1)C1=CC=C2N(C)C(CNC3=CC=C(C=C3)C(N)=N)=NC2=C1	29.6%
12	Experimental	SmallMoleculeDrug	DB04315	Guanosine-5'-Diphosphate	NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1	29.5%
13	Investigational	SmallMoleculeDrug	DB08846	Ellagic Acid	OC1=C(O)C2=C3C(=C1)C(=O)OC1=C3C(=CC(O)=C1O)C(=O)O2	29.0%
14	Experimental; Investigational	SmallMoleculeDrug	DB01873	Epothilone D	[H]\C(=C(\C)[C@]1([H])C\C([H])=C(C)/CCC[C@]([H])(C)[C@]([H])(O)[C@@]([H])(C)C(=O)C(C)(C)[C@@]([H])(O)CC(=O)O1)C1=CSC(C)=N1	28.1%
15	Approved; Investigational	SmallMoleculeDrug	DB11730	Ribociclib	CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(C=N3)N3CCNCC3)N=C2N1C1CCCC1	28.0%
16	Experimental	SmallMoleculeDrug	DB04336	1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea	NC(=N)C1=CC=C(NC(=O)NC2=CC=C(Cl)C=C2)C=C1	26.9%
17	Investigational	SmallMoleculeDrug	DB06281	Torcetrapib	CCOC(=O)N1[C@H](CC)C[C@H](N(CC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C(=O)OC)C2=C1C=CC(=C2)C(F)(F)F	26.9%
18	Approved; Experimental	SmallMoleculeDrug	DB07776	Flavone	O=C1C=C(OC2=CC=CC=C12)C1=CC=CC=C1	26.5%
19	Approved; Investigational	SmallMoleculeDrug	DB12598	Nafamostat	NC(=N)NC1=CC=C(C=C1)C(=O)OC1=CC=C2C=C(C=CC2=C1)C(N)=N	25.8%
20	Experimental	SmallMoleculeDrug	DB03016	CRA_1801	NC(=N)C1=CC2=C(C=C1)N=C(N2)C1=C(O)C=CC=N1	25.7%