QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P80404
No. Gene UniProt ID Protein Name Pathway PDB
1 ABAT P80404 4-aminobutyrate aminotransferase, mitochondrial hsa00250; hsa00280; hsa00410; hsa00640; hsa00650; hsa01100; hsa04727 NA


9 known interactions (drugs) of input target (ABAT): 4-aminobutyrate aminotransferase, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB01080 Vigabatrin Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00160 L-Alanine Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb
4 Experimental SmallMoleculeDrug DB04235 4-Amino Hexanoic Acid Thumb
5 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00119 Pyruvic acid Thumb
8 Approved SmallMoleculeDrug DB00780 Phenelzine Thumb
9 Experimental SmallMoleculeDrug DB01699 (4e)-4-Aminohex-4-Enoic Acid Thumb


20 predicted interactions (drugs) of input target (ABAT): 4-aminobutyrate aminotransferase, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb 37.6%
2 Investigational SmallMoleculeDrug DB05232 Tetrodotoxin Thumb 35.7%
3 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb 31.3%
4 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb 26.1%
5 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 23.1%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00128 L-Aspartic Acid Thumb 21.9%
7 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb 21.5%
8 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb 20.9%
9 Experimental;
Investigational		 SmallMoleculeDrug DB04216 Quercetin Thumb 20.7%
10 Approved;
Investigational		 SmallMoleculeDrug DB01174 Phenobarbital Thumb 20.5%
11 Approved;
Investigational		 SmallMoleculeDrug DB00583 L-Carnitine Thumb 20.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB00837 Progabide Thumb 19.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 19.2%
14 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00167 L-Isoleucine Thumb 19.2%
15 Approved;
Investigational		 BiotechDrug DB00075 Muromonab Thumb 19.2%
16 Approved SmallMoleculeDrug DB01438 Phenazopyridine Thumb 18.9%
17 Approved;
Investigational		 SmallMoleculeDrug DB00350 Minoxidil Thumb 18.8%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB00151 L-Cysteine Thumb 18.1%
19 Approved;
Nutraceutical		 SmallMoleculeDrug DB00133 Serine Thumb 17.8%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB00161 L-Valine Thumb 17.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.