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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q07343
No. Gene UniProt ID Protein Name Pathway PDB
1 PDE4B Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B hsa00230; hsa04024; hsa04928; hsa05032

28 known interactions (drugs) of input target (PDE4B): cAMP-specific 3',5'-cyclic phosphodiesterase 4B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB01791 Piclamilast Thumb
2 Experimental SmallMoleculeDrug DB02660 Filaminast Thumb
3 Approved SmallMoleculeDrug DB00277 Theophylline Thumb
4 Approved;
SmallMoleculeDrug DB00824 Enprofylline Thumb
5 Approved SmallMoleculeDrug DB00651 Dyphylline Thumb
6 Approved;
SmallMoleculeDrug DB01088 Iloprost Thumb
7 Approved;
SmallMoleculeDrug DB05219 Crisaborole Thumb
8 Experimental SmallMoleculeDrug DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Thumb
9 Experimental SmallMoleculeDrug DB04149 (R)-Rolipram Thumb
10 Approved SmallMoleculeDrug DB01427 Amrinone Thumb
11 Experimental SmallMoleculeDrug DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb
12 Experimental SmallMoleculeDrug DB06909 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Thumb
13 Investigational SmallMoleculeDrug DB03849 Cilomilast Thumb
14 Approved;
SmallMoleculeDrug DB05266 Ibudilast Thumb
15 Experimental SmallMoleculeDrug DB03606 (S)-Rolipram Thumb
16 Approved;
SmallMoleculeDrug DB01412 Theobromine Thumb
17 Experimental SmallMoleculeDrug DB03349 8-Bromo-Adenosine-5'-Monophosphate Thumb
18 Approved SmallMoleculeDrug DB00201 Caffeine Thumb
19 Investigational SmallMoleculeDrug DB01954 Rolipram Thumb
20 Approved;
SmallMoleculeDrug DB01113 Papaverine Thumb
21 Approved;
SmallMoleculeDrug DB00806 Pentoxifylline Thumb
22 Experimental SmallMoleculeDrug DB04530 S,S-(2-Hydroxyethyl)Thiocysteine Thumb
23 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb
24 Experimental SmallMoleculeDrug DB01647 Daxalipram Thumb
25 Approved;
SmallMoleculeDrug DB05676 Apremilast Thumb
26 Approved SmallMoleculeDrug DB01656 Roflumilast Thumb
27 Experimental SmallMoleculeDrug DB03807 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb
28 Approved SmallMoleculeDrug DB09283 Trapidil Thumb

20 predicted interactions (drugs) of input target (PDE4B): cAMP-specific 3',5'-cyclic phosphodiesterase 4B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one Thumb 58.0%
2 Investigational SmallMoleculeDrug DB06479 Propentofylline Thumb 56.2%
3 Approved SmallMoleculeDrug DB01303 Oxtriphylline Thumb 52.7%
4 Approved SmallMoleculeDrug DB00975 Dipyridamole Thumb 47.6%
5 Investigational SmallMoleculeDrug DB06246 Exisulind Thumb 46.8%
6 Experimental SmallMoleculeDrug DB07954 3-isobutyl-1-methyl-7H-xanthine Thumb 46.8%
7 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 45.6%
8 Investigational SmallMoleculeDrug DB05298 Tetomilast Thumb 44.8%
9 Experimental SmallMoleculeDrug DB02918 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One Thumb 44.5%
10 Investigational SmallMoleculeDrug DB05876 PDE4 Thumb 44.3%
11 Approved SmallMoleculeDrug DB08811 Tofisopam Thumb 44.3%
12 Experimental SmallMoleculeDrug DB03183 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb 44.0%
13 Experimental SmallMoleculeDrug DB04469 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb 42.0%
14 Experimental SmallMoleculeDrug DB07051 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Thumb 39.9%
15 Experimental SmallMoleculeDrug DB02676 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Thumb 36.9%
16 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 36.5%
17 Experimental;
SmallMoleculeDrug DB03366 Imidazole Thumb 35.4%
18 Approved;
SmallMoleculeDrug DB06751 Drotaverine Thumb 34.9%
19 Experimental SmallMoleculeDrug DB01972 Guanosine-5'-Monophosphate Thumb 33.3%
20 Experimental SmallMoleculeDrug DB04271 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb 32.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.