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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P59796
No. Gene UniProt ID Protein Name Pathway PDB
1 GPX6 P59796 Glutathione peroxidase 6 hsa00480; hsa00590; hsa04918 NA


1 known interactions (drugs) of input target (GPX6): Glutathione peroxidase 6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00143 Glutathione Thumb


16 predicted interactions (drugs) of input target (GPX6): Glutathione peroxidase 6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB04132 S-Hexylglutathione Thumb 19.7%
2 Experimental SmallMoleculeDrug DB04700 GLUTATHIONE SULFINATE Thumb 13.6%
3 Approved;
Investigational		 BiotechDrug DB13151 Anti-inhibitor coagulant complex Thumb 12.7%
4 Approved BiotechDrug DB00036 Coagulation factor VIIa Recombinant Human Thumb 12.3%
5 Experimental SmallMoleculeDrug DB01864 5'-Guanosine-Diphosphate-Monothiophosphate Thumb 11.8%
6 Approved SmallMoleculeDrug DB01120 Gliclazide Thumb 11.7%
7 Experimental SmallMoleculeDrug DB03003 Glutathione Sulfonic Acid Thumb 11.5%
8 Investigational SmallMoleculeDrug DB05434 ABT-510 Thumb 11.5%
9 Experimental SmallMoleculeDrug DB04751 Purvalanol A Thumb 11.4%
10 Investigational BiotechDrug DB04919 Alfimeprase Thumb 11.3%
11 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 11.0%
12 Approved;
Investigational		 BiotechDrug DB00100 Coagulation Factor IX (Recombinant) Thumb 10.8%
13 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00055 Drotrecogin alfa Thumb 10.8%
14 Experimental SmallMoleculeDrug DB03597 Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine Thumb 10.6%
15 Experimental SmallMoleculeDrug DB02144 1,2-diacyl-sn-glycero-3-phosphoinositol Thumb 10.4%
16 Approved SmallMoleculeDrug DB00364 Sucralfate Thumb 10.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.