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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.


18 known interactions (drugs) of input target (MAPK10): Mitogen-activated protein kinase 10
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB08025 N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE Thumb
2 Experimental SmallMoleculeDrug DB08021 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide Thumb
3 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb
4 Experimental SmallMoleculeDrug DB01782 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Thumb
5 Experimental SmallMoleculeDrug DB08011 (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime Thumb
6 Experimental SmallMoleculeDrug DB03084 Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine Thumb
7 Experimental SmallMoleculeDrug DB08010 (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime Thumb
8 Experimental SmallMoleculeDrug DB08026 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide Thumb
9 Experimental SmallMoleculeDrug DB07217 N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide Thumb
10 Experimental SmallMoleculeDrug DB08005 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide Thumb
11 Experimental SmallMoleculeDrug DB03623 9-(4-Hydroxyphenyl)-2,7-Phenanthroline Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
13 Experimental SmallMoleculeDrug DB08023 N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine Thumb
14 Experimental SmallMoleculeDrug DB07010 N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE Thumb
15 Experimental SmallMoleculeDrug DB08555 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline Thumb
16 Experimental SmallMoleculeDrug DB08015 (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime Thumb
17 Experimental SmallMoleculeDrug DB02388 Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine Thumb
18 Experimental SmallMoleculeDrug DB06933 N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide Thumb


20 predicted interactions (drugs) of input target (MAPK10): Mitogen-activated protein kinase 10
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB01942 Formic Acid Thumb 41.7%
2 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 34.1%
3 Approved SmallMoleculeDrug DB01016 Glyburide Thumb 32.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB09462 Glycerin Thumb 30.5%
5 Experimental SmallMoleculeDrug DB03401 1D-myo-inositol 1,4,5-trisphosphate Thumb 29.8%
6 Experimental SmallMoleculeDrug DB01863 Inositol 1,3,4,5-Tetrakisphosphate Thumb 29.6%
7 Approved;
Investigational		 SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb 29.1%
8 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 28.5%
9 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 28.3%
10 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB01065 Melatonin Thumb 27.8%
11 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 27.2%
12 Experimental SmallMoleculeDrug DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose Thumb 25.4%
13 Approved;
Investigational		 SmallMoleculeDrug DB06594 Agomelatine Thumb 24.4%
14 Experimental SmallMoleculeDrug DB04367 Debromohymenialdisine Thumb 24.2%
15 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00155 L-Citrulline Thumb 23.6%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 23.4%
17 Approved;
Investigational		 BiotechDrug DB00108 Natalizumab Thumb 23.3%
18 Approved;
Investigational		 SmallMoleculeDrug DB01169 Arsenic trioxide Thumb 23.1%
19 Experimental SmallMoleculeDrug DB01840 2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate Thumb 22.9%
20 Approved;
Investigational		 BiotechDrug DB00087 Alemtuzumab Thumb 22.9%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.