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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P09601
No. Gene UniProt ID Protein Name Pathway PDB
1 HMOX1 P09601 Heme oxygenase 1 hsa00860; hsa01100; hsa04066; hsa04216; hsa04978; hsa05200; hsa05206; hsa05225; hsa05418

9 known interactions (drugs) of input target (HMOX1): Heme oxygenase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Investigational SmallMoleculeDrug DB04912 Stannsoporfin Thumb
2 Experimental SmallMoleculeDrug DB02468 12-Phenylheme Thumb
3 Experimental SmallMoleculeDrug DB07342 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone Thumb
4 Experimental SmallMoleculeDrug DB03906 2-Phenylheme Thumb
5 Experimental SmallMoleculeDrug DB02073 Biliverdine IX Alpha Thumb
6 Approved;
SmallMoleculeDrug DB01942 Formic Acid Thumb
7 Experimental SmallMoleculeDrug DB06914 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE Thumb
8 Experimental SmallMoleculeDrug DB04803 Verdoheme Thumb
9 Approved;
SmallMoleculeDrug DB00157 NADH Thumb

20 predicted interactions (drugs) of input target (HMOX1): Heme oxygenase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose Thumb 34.8%
2 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb 31.4%
3 Experimental SmallMoleculeDrug DB03059 Acetoacetyl-CoA Thumb 25.6%
4 Approved;
SmallMoleculeDrug DB00129 Ornithine Thumb 24.7%
5 Approved;
SmallMoleculeDrug DB00115 Cyanocobalamin Thumb 23.4%
6 Approved;
Vet approved
SmallMoleculeDrug DB00741 Hydrocortisone Thumb 21.2%
7 Experimental SmallMoleculeDrug DB01832 4-[Hydroxy-[Methyl-Phosphinoyl]]-3-Oxo-Butanoic Acid Thumb 20.5%
8 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 20.0%
9 Approved;
SmallMoleculeDrug DB00761 Potassium Chloride Thumb 18.7%
10 Approved;
SmallMoleculeDrug DB00123 L-Lysine Thumb 18.4%
11 Approved;
SmallMoleculeDrug DB00170 Menadione Thumb 18.1%
12 Experimental SmallMoleculeDrug DB02451 B-nonylglucoside Thumb 17.7%
13 Experimental SmallMoleculeDrug DB03940 Oxamic Acid Thumb 17.6%
14 Experimental SmallMoleculeDrug DB07870 (2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID Thumb 17.4%
15 Experimental SmallMoleculeDrug DB03945 N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium Thumb 17.3%
16 Approved;
Vet approved
SmallMoleculeDrug DB00626 Bacitracin Thumb 17.0%
17 Approved SmallMoleculeDrug DB00691 Moexipril Thumb 16.9%
18 Approved;
SmallMoleculeDrug DB00151 L-Cysteine Thumb 16.6%
19 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 16.6%
20 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 16.3%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.