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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q96T66
No. Gene UniProt ID Protein Name Pathway PDB
1 NMNAT3 Q96T66 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 hsa00760; hsa01100 1NUP; 1NUQ; 1NUR; 1NUS; 1NUT; 1NUU


3 known interactions (drugs) of input target (NMNAT3): Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate Thumb
2 Experimental SmallMoleculeDrug DB04099 Deamido-Nad+ Thumb
3 Experimental SmallMoleculeDrug DB03227 Nicotinamide Mononucleotide Thumb


20 predicted interactions (drugs) of input target (NMNAT3): Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB02930 Adenosine 5'-[γ-thio]triphosphate Thumb 21.0%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 18.5%
3 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb 17.3%
4 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 15.9%
5 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb 15.9%
6 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 14.9%
7 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 14.0%
8 Approved SmallMoleculeDrug DB00630 Alendronic acid Thumb 13.9%
9 Investigational SmallMoleculeDrug DB05217 GMX1777 Thumb 13.8%
10 Approved;
Nutraceutical		 SmallMoleculeDrug DB01436 Alfacalcidol Thumb 13.7%
11 Investigational SmallMoleculeDrug DB06042 ZEN-012 Thumb 13.5%
12 Approved SmallMoleculeDrug DB04941 Crofelemer Thumb 13.5%
13 Approved SmallMoleculeDrug DB06822 Tinzaparin Thumb 12.9%
14 Experimental SmallMoleculeDrug DB03573 WRR-99 Thumb 12.8%
15 Experimental SmallMoleculeDrug DB03719 N-Ethyl-5'-Carboxamido Adenosine Thumb 12.4%
16 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 12.4%
17 Approved;
Investigational		 BiotechDrug DB06205 Hyaluronidase (Human Recombinant) Thumb 12.3%
18 Experimental SmallMoleculeDrug DB03732 Etheno-Nadp Thumb 12.1%
19 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 12.0%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB00172 L-Proline Thumb 11.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.