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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P42081
No. Gene UniProt ID Protein Name Pathway PDB
1 CD86 P42081 T-lymphocyte activation antigen CD86 hsa04514; hsa04620; hsa04672; hsa04940; hsa05167; hsa05202; hsa05320; hsa05322; hsa05323; hsa05330; hsa05332; hsa05416 1I85; 1NCN

3 known interactions (drugs) of input target (CD86): T-lymphocyte activation antigen CD86
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved BiotechDrug DB00098 Antithymocyte immunoglobulin (rabbit) Thumb
2 Approved;
BiotechDrug DB06681 Belatacept Thumb
3 Approved BiotechDrug DB01281 Abatacept Thumb

20 predicted interactions (drugs) of input target (CD86): T-lymphocyte activation antigen CD86
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb 26.2%
2 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb 24.7%
3 Investigational BiotechDrug DB04901 Galiximab Thumb 24.1%
4 Approved;
BiotechDrug DB12698 Ibalizumab Thumb 20.6%
5 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 19.9%
6 Approved;
BiotechDrug DB11714 Durvalumab Thumb 19.5%
7 Experimental SmallMoleculeDrug DB07929 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE Thumb 14.9%
8 Approved;
SmallMoleculeDrug DB09290 Ramosetron Thumb 14.8%
9 Approved;
SmallMoleculeDrug DB08889 Carfilzomib Thumb 14.7%
10 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb 14.4%
11 Experimental SmallMoleculeDrug DB04367 Debromohymenialdisine Thumb 14.3%
12 Approved SmallMoleculeDrug DB00459 Acitretin Thumb 14.1%
13 Investigational;
SmallMoleculeDrug DB01992 Coenzyme A Thumb 13.3%
14 Approved;
SmallMoleculeDrug DB03756 Doconexent Thumb 12.6%
15 Approved SmallMoleculeDrug DB00232 Methyclothiazide Thumb 12.5%
16 Approved;
SmallMoleculeDrug DB00914 Phenformin Thumb 12.3%
17 Investigational SmallMoleculeDrug DB01645 Genistein Thumb 12.1%
18 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 12.1%
19 Approved;
SmallMoleculeDrug DB00119 Pyruvic acid Thumb 12.1%
20 Approved;
SmallMoleculeDrug DB00138 Cystine Thumb 12.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.