QuartataWeb 1.0

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q07973

No. Gene UniProt ID Protein Name Pathway PDB

1 CYP24A1 Q07973 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial hsa00100; hsa01100; hsa04928; hsa05206 NA

1 known interactions (drugs) of input target (CYP24A1): 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Image
1	Investigational	SmallMoleculeDrug	DB05024	CTA018	NA

20 predicted interactions (drugs) of input target (CYP24A1): 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Experimental	SmallMoleculeDrug	DB04137	Guanosine-5'-Triphosphate	NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1	23.5%
2	Experimental	SmallMoleculeDrug	DB03814	2-(N-Morpholino)-Ethanesulfonic Acid	[O-]S(=O)(=O)CC[NH+]1CCOCC1	18.8%
3	Approved	SmallMoleculeDrug	DB06410	Doxercalciferol	[H]\C(\C(\[H])=C1/CCC[C@@]2(C)[C@@]1([H])CC[C@]2([H])[C@]([H])(C)C(\[H])=C(/[H])[C@]([H])(C)C(C)C)=C1/C[C@@]([H])(O)C[C@]([H])(O)C1=C	15.2%
4	Approved; Investigational	SmallMoleculeDrug	DB03615	Ribostamycin	[H][C@]1(CO)O[C@@]([H])(O[C@]2([H])[C@@]([H])(O)[C@]([H])(N)C[C@]([H])(N)[C@@]2([H])O[C@@]2([H])O[C@]([H])(CN)[C@@]([H])(O)[C@]([H])(O)[C@@]2([H])N)[C@]([H])(O)[C@]1([H])O	14.7%
5	Approved	SmallMoleculeDrug	DB00780	Phenelzine	NNCCC1=CC=CC=C1	14.5%
6	Approved; Investigational	SmallMoleculeDrug	DB09462	Glycerin	OCC(O)CO	14.2%
7	Approved; Investigational	SmallMoleculeDrug	DB04540	Cholesterol	[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C	14.1%
8	Investigational	SmallMoleculeDrug	DB06195	Seliciclib	CC[C@H](CO)NC1=NC(NCC2=CC=CC=C2)=C2N=CN(C(C)C)C2=N1	13.9%
9	Investigational	SmallMoleculeDrug	DB05295	Eldecalcitol	[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)[C@@H](OCCCO)[C@H](O)C1=C)[C@H](C)CCCC(C)(C)O	13.1%
10	Approved; Vet approved	SmallMoleculeDrug	DB00396	Progesterone	[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C	13.0%
11	Experimental	SmallMoleculeDrug	DB07691	2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid	OC(=O)C1=C(NC(=O)C2=CC=CC(=C2)S(=O)(=O)N2CCC3=CC=CC=C3C2)C=CC=C1	12.8%
12	Investigational	SmallMoleculeDrug	DB04891	Becocalcidiol	CC[C@@](C)([H])[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1/C[C@](O)([H])C(=C)[C@]([H])(O)C1	12.4%
13	Approved; Nutraceutical	SmallMoleculeDrug	DB00126	Vitamin C	[H][C@@]1(OC(=O)C(O)=C1O)[C@@H](O)CO	12.1%
14	Experimental	SmallMoleculeDrug	DB07530	(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol	[H][C@]1(CC[C@](C)(CCC#CC(O)(C(F)(F)F)C(F)(F)F)C1(C)C)\C=C\C=C1C[C@](O)([H])C[C@@](O)([H])C1	11.8%
15	Approved	SmallMoleculeDrug	DB03754	Tromethamine	NC(CO)(CO)CO	11.7%
16	Approved; Investigational	SmallMoleculeDrug	DB00905	Bimatoprost	CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1	11.6%
17	Investigational	SmallMoleculeDrug	DB13930	Ulixertinib	[H]N([C@H](CO)C1=CC(Cl)=CC=C1)C(=O)C1=CC(=CN1[H])C1=CC(=NC=C1Cl)N([H])C(C)C	11.5%
18	Approved; Investigational	SmallMoleculeDrug	DB08908	Dimethyl fumarate	[H]\C(=C(\[H])C(=O)OC)C(=O)OC	11.4%
19	Experimental	SmallMoleculeDrug	DB08163	5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine	[H][C@]1(CN(C)CCCCON)O[C@@]([H])(N2C(C=C)=NC3=C(N)N=CN=C23)[C@]([H])(O)[C@]1([H])O	11.4%
20	Approved; Nutraceutical	SmallMoleculeDrug	DB00159	Icosapent	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O	11.3%