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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P09960
No. Gene UniProt ID Protein Name Pathway PDB
1 LTA4H P09960 Leukotriene A-4 hydrolase hsa00590; hsa01100

22 known interactions (drugs) of input target (LTA4H): Leukotriene A-4 hydrolase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB02352 3-(Benzyloxy)Pyridin-2-Amine Thumb
2 Approved SmallMoleculeDrug DB01197 Captopril Thumb
3 Experimental;
SmallMoleculeDrug DB03366 Imidazole Thumb
4 Experimental SmallMoleculeDrug DB08466 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol Thumb
5 Experimental SmallMoleculeDrug DB02062 N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Thumb
6 Experimental;
SmallMoleculeDrug DB03424 Ubenimex Thumb
7 Experimental SmallMoleculeDrug DB07260 N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline Thumb
8 Experimental SmallMoleculeDrug DB07237 {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone Thumb
9 Experimental SmallMoleculeDrug DB07196 N-methyl-1-(2-thiophen-2-ylphenyl)methanamine Thumb
10 Experimental SmallMoleculeDrug DB07104 4-amino-N-[4-(benzyloxy)phenyl]butanamide Thumb
11 Experimental SmallMoleculeDrug DB07094 1-(2,2'-bithiophen-5-yl)methanamine Thumb
12 Experimental SmallMoleculeDrug DB08040 N-[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-L-alanine Thumb
13 Experimental SmallMoleculeDrug DB07259 1-(4-thiophen-2-ylphenyl)methanamine Thumb
14 Experimental SmallMoleculeDrug DB06851 N-(pyridin-3-ylmethyl)aniline Thumb
15 Investigational SmallMoleculeDrug DB11781 Tosedostat Thumb
16 Experimental SmallMoleculeDrug DB06828 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole Thumb
17 Investigational SmallMoleculeDrug DB05177 DG051 Thumb
18 Experimental SmallMoleculeDrug DB07102 (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid Thumb
19 Experimental SmallMoleculeDrug DB07099 N-[4-(benzyloxy)phenyl]glycinamide Thumb
20 Experimental SmallMoleculeDrug DB07258 (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol Thumb
21 Experimental SmallMoleculeDrug DB06917 (4-fluorophenyl)(pyridin-4-yl)methanone Thumb
22 Experimental SmallMoleculeDrug DB07292 4-(2-amino-1,3-thiazol-4-yl)phenol Thumb

20 predicted interactions (drugs) of input target (LTA4H): Leukotriene A-4 hydrolase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 50.3%
2 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 30.7%
3 Approved;
SmallMoleculeDrug DB00313 Valproic Acid Thumb 30.2%
4 Approved BiotechDrug DB11294 Coccidioides immitis spherule Thumb 30.0%
5 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 28.2%
6 Experimental SmallMoleculeDrug DB03951 N-acetyl-D-glucosamine-6-phosphate Thumb 28.2%
7 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb 28.0%
8 Approved;
SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb 27.0%
9 Approved;
SmallMoleculeDrug DB00747 Scopolamine Thumb 26.6%
10 Approved;
SmallMoleculeDrug DB03796 Palmitic Acid Thumb 26.6%
11 Experimental SmallMoleculeDrug DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb 26.2%
12 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 26.0%
13 Approved SmallMoleculeDrug DB11348 Calcium Phosphate Thumb 26.0%
14 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 25.8%
15 Experimental SmallMoleculeDrug DB04530 S,S-(2-Hydroxyethyl)Thiocysteine Thumb 25.5%
16 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 24.5%
17 Approved;
SmallMoleculeDrug DB00605 Sulindac Thumb 23.9%
18 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb 23.8%
19 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 23.3%
20 Approved;
SmallMoleculeDrug DB00173 Adenine Thumb 23.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.