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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08048
No. Gene UniProt ID Protein Name Pathway PDB
1 ZFY P08048 Zinc finger Y-chromosomal protein NA 1KLR; 1KLS; 1XRZ; 5ZNF; 7ZNF


2 known interactions (drugs) of input target (ZFY): Zinc finger Y-chromosomal protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB05483 PCL-016 Thumb
2 Experimental SmallMoleculeDrug DB02884 Beta-Cyclohexyl-Alanine Thumb


20 predicted interactions (drugs) of input target (ZFY): Zinc finger Y-chromosomal protein
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 20.7%
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00167 L-Isoleucine Thumb 19.5%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 17.0%
4 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb 16.4%
5 Experimental SmallMoleculeDrug DB02585 4-(Hydroxymethyl)Benzamidine Thumb 14.9%
6 Investigational BiotechDrug DB04959 HspE7 Thumb 14.8%
7 Experimental SmallMoleculeDrug DB07177 (5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID Thumb 13.7%
8 Investigational SmallMoleculeDrug DB11831 Dinitrochlorobenzene Thumb 13.2%
9 Experimental SmallMoleculeDrug DB08180 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE Thumb 13.0%
10 Experimental SmallMoleculeDrug DB03832 3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium Thumb 12.9%
11 Approved;
Nutraceutical		 SmallMoleculeDrug DB00133 Serine Thumb 12.9%
12 Experimental SmallMoleculeDrug DB06990 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID Thumb 12.7%
13 Approved;
Investigational		 SmallMoleculeDrug DB08862 Cholecystokinin Thumb 12.4%
14 Approved;
Withdrawn		 BiotechDrug DB06752 Chymopapain Thumb 12.0%
15 Experimental SmallMoleculeDrug DB02955 Ricinoleic Acid Thumb 11.9%
16 Experimental SmallMoleculeDrug DB08651 3'-THIO-THYMIDINE-5'-PHOSPHATE Thumb 11.9%
17 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb 11.8%
18 Approved;
Investigational		 SmallMoleculeDrug DB04540 Cholesterol Thumb 11.7%
19 Approved SmallMoleculeDrug DB00363 Clozapine Thumb 11.6%
20 Experimental SmallMoleculeDrug DB02359 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine Thumb 11.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.