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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P13612
No. Gene UniProt ID Protein Name Pathway PDB
1 ITGA4 P13612 Integrin alpha-4 hsa04151; hsa04510; hsa04512; hsa04514; hsa04640; hsa04670; hsa04672; hsa04810; hsa05140; hsa05165; hsa05410; hsa05412; hsa05414 3V4P; 3V4V; 4HKC

7 known interactions (drugs) of input target (ITGA4): Integrin alpha-4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB06822 Tinzaparin Thumb
2 Investigational SmallMoleculeDrug DB05092 CDP323 Thumb
3 Approved BiotechDrug DB09033 Vedolizumab Thumb
4 Investigational SmallMoleculeDrug DB04997 ATL1102 Thumb
5 Investigational SmallMoleculeDrug DB05468 R411 Thumb
6 Investigational SmallMoleculeDrug DB05122 R1295 Thumb
7 Approved;
BiotechDrug DB00108 Natalizumab Thumb

20 predicted interactions (drugs) of input target (ITGA4): Integrin alpha-4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 39.6%
2 Approved;
SmallMoleculeDrug DB00157 NADH Thumb 36.0%
3 Approved BiotechDrug DB00051 Adalimumab Thumb 26.5%
4 Approved;
BiotechDrug DB00112 Bevacizumab Thumb 26.2%
5 Approved;
BiotechDrug DB00092 Alefacept Thumb 25.6%
6 Approved BiotechDrug DB00073 Rituximab Thumb 24.4%
7 Approved;
BiotechDrug DB00081 Tositumomab Thumb 24.4%
8 Approved;
BiotechDrug DB00110 Palivizumab Thumb 23.5%
9 Approved;
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 23.3%
10 Approved;
BiotechDrug DB00095 Efalizumab Thumb 22.2%
11 Approved;
BiotechDrug DB00078 Ibritumomab tiuxetan Thumb 21.5%
12 Approved;
BiotechDrug DB00005 Etanercept Thumb 21.0%
13 Experimental SmallMoleculeDrug DB08342 S-PALMITOYL-L-CYSTEINE Thumb 20.8%
14 Approved;
BiotechDrug DB00056 Gemtuzumab ozogamicin Thumb 20.5%
15 Experimental SmallMoleculeDrug DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Thumb 19.9%
16 Approved;
SmallMoleculeDrug DB01404 Ginseng Thumb 19.5%
17 Approved;
BiotechDrug DB00072 Trastuzumab Thumb 19.5%
18 Approved SmallMoleculeDrug DB00480 Lenalidomide Thumb 19.0%
19 Experimental SmallMoleculeDrug DB04510 3-phospho-D-glyceric acid Thumb 18.8%
20 Investigational SmallMoleculeDrug DB12637 Onapristone Thumb 18.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.