QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35626
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRBK2 P35626 Beta-adrenergic receptor kinase 2 hsa04062; hsa04144; hsa04340; hsa04724; hsa04740; hsa05032 NA


1 known interactions (drugs) of input target (ADRBK2): Beta-adrenergic receptor kinase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational;
Nutraceutical		 SmallMoleculeDrug DB00171 ATP Thumb


20 predicted interactions (drugs) of input target (ADRBK2): Beta-adrenergic receptor kinase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 31.6%
2 Approved SmallMoleculeDrug DB01016 Glyburide Thumb 22.9%
3 Approved;
Investigational		 SmallMoleculeDrug DB01599 Probucol Thumb 16.0%
4 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 15.4%
5 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 13.6%
6 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 13.5%
7 Approved;
Investigational		 SmallMoleculeDrug DB00786 Marimastat Thumb 13.0%
8 Approved SmallMoleculeDrug DB09063 Ceritinib Thumb 12.6%
9 Experimental SmallMoleculeDrug DB04367 Debromohymenialdisine Thumb 12.2%
10 Approved SmallMoleculeDrug DB08865 Crizotinib Thumb 12.0%
11 Approved;
Investigational		 SmallMoleculeDrug DB09220 Nicorandil Thumb 11.9%
12 Investigational SmallMoleculeDrug DB05184 XL228 Thumb 11.7%
13 Experimental SmallMoleculeDrug DB08597 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine Thumb 11.7%
14 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 11.7%
15 Approved;
Investigational		 SmallMoleculeDrug DB00845 Clofazimine Thumb 11.4%
16 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb 11.0%
17 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 11.0%
18 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 10.9%
19 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00167 L-Isoleucine Thumb 10.7%
20 Approved;
Investigational		 SmallMoleculeDrug DB11363 Alectinib Thumb 10.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.