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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

7 known interactions (drugs) of input target (MAPK3): Mitogen-activated protein kinase 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB08862 Cholecystokinin Thumb
2 Approved;
SmallMoleculeDrug DB00605 Sulindac Thumb
3 Experimental SmallMoleculeDrug DB02733 Purvalanol Thumb
4 Investigational SmallMoleculeDrug DB13930 Ulixertinib Thumb
5 Approved;
SmallMoleculeDrug DB01169 Arsenic trioxide Thumb
6 Investigational SmallMoleculeDrug DB06195 Seliciclib Thumb
7 Experimental SmallMoleculeDrug DB04604 5-iodotubercidin Thumb

20 predicted interactions (drugs) of input target (MAPK3): Mitogen-activated protein kinase 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB02116 Olomoucine Thumb 41.7%
2 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 35.3%
3 Investigational SmallMoleculeDrug DB06641 Perifosine Thumb 25.8%
4 Experimental SmallMoleculeDrug DB07794 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE Thumb 25.6%
5 Experimental SmallMoleculeDrug DB06877 N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE Thumb 25.5%
6 Experimental SmallMoleculeDrug DB03428 SU9516 Thumb 24.9%
7 Approved;
SmallMoleculeDrug DB01149 Nefazodone Thumb 24.5%
8 Experimental SmallMoleculeDrug DB08521 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE Thumb 23.8%
9 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 22.9%
10 Experimental SmallMoleculeDrug DB07364 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE Thumb 22.3%
11 Experimental SmallMoleculeDrug DB07010 N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE Thumb 22.1%
12 Approved;
SmallMoleculeDrug DB00173 Adenine Thumb 22.0%
13 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 21.7%
14 Experimental SmallMoleculeDrug DB04454 Alpha-Aminobutyric Acid Thumb 21.6%
15 Experimental SmallMoleculeDrug DB02052 Indirubin-3'-Monoxime Thumb 21.6%
16 Experimental SmallMoleculeDrug DB07264 (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE Thumb 21.5%
17 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 21.2%
18 Experimental;
SmallMoleculeDrug DB03496 Alvocidib Thumb 20.9%
19 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 20.7%
20 Approved;
SmallMoleculeDrug DB00907 Cocaine Thumb 20.6%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.