QuartataWeb 1.0

7 known interactions (drugs) of input target (MAPK3): Mitogen-activated protein kinase 3

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Approved; Investigational	SmallMoleculeDrug	DB08862	Cholecystokinin	NA
2	Approved; Investigational	SmallMoleculeDrug	DB00605	Sulindac	CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(C=C1)S(C)=O
3	Experimental	SmallMoleculeDrug	DB02733	Purvalanol	[H][C@@](CO)(NC1=NC2=C(N=CN2C(C)C)C(NC2=CC=C(C(O)=O)C(Cl)=C2)=N1)C(C)C
4	Investigational	SmallMoleculeDrug	DB13930	Ulixertinib	[H]N([C@H](CO)C1=CC(Cl)=CC=C1)C(=O)C1=CC(=CN1[H])C1=CC(=NC=C1Cl)N([H])C(C)C
5	Approved; Investigational	SmallMoleculeDrug	DB01169	Arsenic trioxide	O=[As]O[As]=O
6	Investigational	SmallMoleculeDrug	DB06195	Seliciclib	CC[C@H](CO)NC1=NC(NCC2=CC=CC=C2)=C2N=CN(C(C)C)C2=N1
7	Experimental	SmallMoleculeDrug	DB04604	5-iodotubercidin	[H][C@]1(CO)O[C@@]([H])(N2C=C(I)C3=C(N)N=CN=C23)[C@]([H])(O)[C@]1([H])O

20 predicted interactions (drugs) of input target (MAPK3): Mitogen-activated protein kinase 3

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Experimental	SmallMoleculeDrug	DB02116	Olomoucine	CN1C=NC2=C1N=C(NCCO)N=C2NCC1=CC=CC=C1	41.7%
2	Approved; Investigational	SmallMoleculeDrug	DB12010	Fostamatinib	COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC	35.3%
3	Investigational	SmallMoleculeDrug	DB06641	Perifosine	CCCCCCCCCCCCCCCCCCOP([O-])(=O)OC1CC[N+](C)(C)CC1	25.8%
4	Experimental	SmallMoleculeDrug	DB07794	5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE	NC1=NNC2=C1C=C(N=N2)C1=C2C=CC=CN2N=C1C1=CC=CC=C1	25.6%
5	Experimental	SmallMoleculeDrug	DB06877	N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE	CN(C)C(=O)C1=CC(=CN1)C1=NNC=C1C1=CC=CC=C1	25.5%
6	Experimental	SmallMoleculeDrug	DB03428	SU9516	COC1=CC=C2NC(=O)\C(=C/C3=CN=CN3)C2=C1	24.9%
7	Approved; Withdrawn	SmallMoleculeDrug	DB01149	Nefazodone	CCC1=NN(CCCN2CCN(CC2)C2=CC(Cl)=CC=C2)C(=O)N1CCOC1=CC=CC=C1	24.5%
8	Experimental	SmallMoleculeDrug	DB08521	4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE	C[S@@](=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1	23.8%
9	Approved	SmallMoleculeDrug	DB00321	Amitriptyline	CN(C)CCC=C1C2=CC=CC=C2CCC2=CC=CC=C12	22.9%
10	Experimental	SmallMoleculeDrug	DB07364	6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE	CCCCC1=C(NC2=NC=CN=C12)C1=CC=C(O)C=C1	22.3%
11	Experimental	SmallMoleculeDrug	DB07010	N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE	ClC1=CC(=CC=C1)C1=CNN=C1C1=CNC(=C1)C(=O)NCC1=CC=CC=C1	22.1%
12	Approved; Nutraceutical	SmallMoleculeDrug	DB00173	Adenine	NC1=C2NC=NC2=NC=N1	22.0%
13	Approved; Investigational	SmallMoleculeDrug	DB01593	Zinc	[Zn]	21.7%
14	Experimental	SmallMoleculeDrug	DB04454	Alpha-Aminobutyric Acid	CC[C@@H](N)C(O)=O	21.6%
15	Experimental	SmallMoleculeDrug	DB02052	Indirubin-3'-Monoxime	O\N=C1\C(\NC2=C\1C=CC=C2)=C1\C(=O)NC2=C1C=CC=C2	21.6%
16	Experimental	SmallMoleculeDrug	DB07264	(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE	[H][C@](CO)(NC(=O)C1=CC(=CN1)C1=NNC=C1C1=CC=CC(Cl)=C1)C1=CC(Cl)=C(F)C=C1	21.5%
17	Approved	SmallMoleculeDrug	DB00215	Citalopram	CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C1=CC=C(F)C=C1	21.2%
18	Experimental; Investigational	SmallMoleculeDrug	DB03496	Alvocidib	CN1CC[C@@H]([C@H](O)C1)C1=C(O)C=C(O)C2=C1OC(=CC2=O)C1=CC=CC=C1Cl	20.9%
19	Approved	SmallMoleculeDrug	DB00675	Tamoxifen	CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1	20.7%
20	Approved; Illicit	SmallMoleculeDrug	DB00907	Cocaine	[H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)C1=CC=CC=C1)C(=O)OC)N2C	20.6%