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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P49765
No. Gene UniProt ID Protein Name Pathway PDB
1 VEGFB P49765 Vascular endothelial growth factor B hsa04010; hsa04014; hsa04015; hsa04151; hsa04510; hsa04926; hsa04933; hsa05200 2C7W; 2VWE; 2XAC


1 known interactions (drugs) of input target (VEGFB): Vascular endothelial growth factor B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved BiotechDrug DB08885 Aflibercept Thumb


20 predicted interactions (drugs) of input target (VEGFB): Vascular endothelial growth factor B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 28.4%
2 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 24.3%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00151 L-Cysteine Thumb 22.7%
4 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 21.9%
5 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 18.8%
6 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 18.2%
7 Experimental SmallMoleculeDrug DB08236 (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Thumb 14.5%
8 Experimental SmallMoleculeDrug DB08235 N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Thumb 14.0%
9 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb 14.0%
10 Investigational SmallMoleculeDrug DB05434 ABT-510 Thumb 13.8%
11 Experimental SmallMoleculeDrug DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Thumb 13.7%
12 Investigational BiotechDrug DB06642 Bevasiranib Thumb 13.6%
13 Investigational SmallMoleculeDrug DB05969 SNS-032 Thumb 13.3%
14 Experimental SmallMoleculeDrug DB04474 1-Anilino-8-Naphthalene Sulfonate Thumb 13.1%
15 Experimental SmallMoleculeDrug DB02556 D-Phenylalanine Thumb 12.9%
16 Experimental SmallMoleculeDrug DB04510 3-phospho-D-glyceric acid Thumb 12.7%
17 Approved;
Investigational		 SmallMoleculeDrug DB12965 Silver Thumb 12.6%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB00139 Succinic acid Thumb 12.5%
19 Approved SmallMoleculeDrug DB01120 Gliclazide Thumb 12.2%
20 Approved;
Investigational		 SmallMoleculeDrug DB03247 Flavin mononucleotide Thumb 12.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.