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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P16118
No. Gene UniProt ID Protein Name Pathway PDB
1 PFKFB1 P16118 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 hsa00051; hsa04152; hsa04922 1K6M

5 known interactions (drugs) of input target (PFKFB1): 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB02393 D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate Thumb
2 Experimental SmallMoleculeDrug DB04493 Fructose-6-Phosphate Thumb
3 Experimental SmallMoleculeDrug DB02515 3-Phosphoglycerol Thumb
4 Experimental SmallMoleculeDrug DB02930 Adenosine 5'-[γ-thio]triphosphate Thumb
5 Experimental SmallMoleculeDrug DB04137 Guanosine-5'-Triphosphate Thumb

20 predicted interactions (drugs) of input target (PFKFB1): 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00139 Succinic acid Thumb 22.4%
2 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 21.9%
3 Investigational SmallMoleculeDrug DB05518 Managlinat dialanetil Thumb 21.8%
4 Approved;
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 20.1%
5 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 19.3%
6 Investigational BiotechDrug DB05202 Egaptivon pegol Thumb 18.5%
7 Experimental SmallMoleculeDrug DB02076 6-phospho-D-gluconic acid Thumb 18.5%
8 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb 18.1%
9 Experimental SmallMoleculeDrug DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose Thumb 17.8%
10 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb 17.6%
11 Experimental SmallMoleculeDrug DB01972 Guanosine-5'-Monophosphate Thumb 17.3%
12 Approved;
SmallMoleculeDrug DB00786 Marimastat Thumb 17.2%
13 Approved;
SmallMoleculeDrug DB03088 Pidolic Acid Thumb 17.2%
14 Approved SmallMoleculeDrug DB00201 Caffeine Thumb 16.5%
15 Approved SmallMoleculeDrug DB11348 Calcium Phosphate Thumb 16.3%
16 Experimental SmallMoleculeDrug DB02848 {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Thumb 16.2%
17 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 15.6%
18 Experimental SmallMoleculeDrug DB02153 3-Sulfinoalanine Thumb 15.0%
19 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 14.8%
20 Experimental SmallMoleculeDrug DB02547 Guanosine-5'-Diphosphate-Rhamnose Thumb 14.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.