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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q08493
No. Gene UniProt ID Protein Name Pathway PDB
1 PDE4C Q08493 cAMP-specific 3',5'-cyclic phosphodiesterase 4C hsa00230; hsa04024; hsa04928; hsa05032 1LXU; 2QYM

9 known interactions (drugs) of input target (PDE4C): cAMP-specific 3',5'-cyclic phosphodiesterase 4C
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB01791 Piclamilast Thumb
2 Approved SmallMoleculeDrug DB00201 Caffeine Thumb
3 Approved;
SmallMoleculeDrug DB01088 Iloprost Thumb
4 Approved;
SmallMoleculeDrug DB05219 Crisaborole Thumb
5 Investigational SmallMoleculeDrug DB06246 Exisulind Thumb
6 Approved SmallMoleculeDrug DB01656 Roflumilast Thumb
7 Approved SmallMoleculeDrug DB00651 Dyphylline Thumb
8 Approved;
SmallMoleculeDrug DB05266 Ibudilast Thumb
9 Approved SmallMoleculeDrug DB09283 Trapidil Thumb

20 predicted interactions (drugs) of input target (PDE4C): cAMP-specific 3',5'-cyclic phosphodiesterase 4C
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB05676 Apremilast Thumb 50.8%
2 Experimental SmallMoleculeDrug DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Thumb 49.8%
3 Approved SmallMoleculeDrug DB00277 Theophylline Thumb 49.5%
4 Experimental SmallMoleculeDrug DB07954 3-isobutyl-1-methyl-7H-xanthine Thumb 48.8%
5 Approved;
SmallMoleculeDrug DB00824 Enprofylline Thumb 47.5%
6 Experimental SmallMoleculeDrug DB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one Thumb 47.2%
7 Approved;
SmallMoleculeDrug DB00806 Pentoxifylline Thumb 47.1%
8 Experimental SmallMoleculeDrug DB03606 (S)-Rolipram Thumb 46.2%
9 Approved SmallMoleculeDrug DB08811 Tofisopam Thumb 44.9%
10 Experimental SmallMoleculeDrug DB04149 (R)-Rolipram Thumb 42.2%
11 Investigational SmallMoleculeDrug DB01954 Rolipram Thumb 42.1%
12 Approved SmallMoleculeDrug DB00975 Dipyridamole Thumb 40.3%
13 Approved;
SmallMoleculeDrug DB01412 Theobromine Thumb 40.3%
14 Investigational SmallMoleculeDrug DB03849 Cilomilast Thumb 39.2%
15 Approved SmallMoleculeDrug DB01427 Amrinone Thumb 37.9%
16 Approved SmallMoleculeDrug DB01303 Oxtriphylline Thumb 36.8%
17 Experimental SmallMoleculeDrug DB04271 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb 36.1%
18 Investigational SmallMoleculeDrug DB06479 Propentofylline Thumb 36.0%
19 Experimental SmallMoleculeDrug DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Thumb 35.6%
20 Experimental SmallMoleculeDrug DB04530 S,S-(2-Hydroxyethyl)Thiocysteine Thumb 34.9%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.