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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P04746
No. Gene UniProt ID Protein Name Pathway PDB
1 AMY2A P04746 Pancreatic alpha-amylase hsa00500; hsa01100; hsa04972; hsa04973

13 known interactions (drugs) of input target (AMY2A): Pancreatic alpha-amylase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
2 Experimental SmallMoleculeDrug DB03439 4,6-dideoxy-4-amino-alpha-D-glucose Thumb
3 Experimental SmallMoleculeDrug DB03773 alpha-D-quinovopyranose Thumb
4 Experimental SmallMoleculeDrug DB01922 Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam Thumb
5 Experimental SmallMoleculeDrug DB03971 Acarbose Derived Hexasaccharide Thumb
6 Experimental SmallMoleculeDrug DB02889 4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose Thumb
7 Experimental SmallMoleculeDrug DB03495 4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose Thumb
8 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb
9 Experimental SmallMoleculeDrug DB03092 5-Hydroxymethyl-Chonduritol Thumb
10 Approved;
SmallMoleculeDrug DB03088 Pidolic Acid Thumb
11 Experimental SmallMoleculeDrug DB04453 4-O-(4,6-Dideoxy-4-{[4-[(4-O-Hexopyranosylhexopyranosyl)Oxy]-5,6-Dihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Hexopyranosyl)Hexopyranose Thumb
12 Approved;
SmallMoleculeDrug DB00284 Acarbose Thumb
13 Experimental SmallMoleculeDrug DB02218 N-[4-hydroxymethyl-cyclohexan-6-yl-1,2,3-triol]-4,6-dideoxy-4-aminoglucopyranoside Thumb

20 predicted interactions (drugs) of input target (AMY2A): Pancreatic alpha-amylase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb 29.8%
2 Experimental SmallMoleculeDrug DB03277 alpha-maltotriose Thumb 28.8%
3 Experimental SmallMoleculeDrug DB02730 4-Methylthio-Alpha-D-Mannose Thumb 27.2%
4 Approved;
SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 25.5%
5 Experimental SmallMoleculeDrug DB02466 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid Thumb 23.3%
6 Approved BiotechDrug DB11572 Thrombin Alfa Thumb 23.0%
7 Approved;
SmallMoleculeDrug DB00150 L-Tryptophan Thumb 22.7%
8 Approved;
Vet approved
SmallMoleculeDrug DB00145 Glycine Thumb 22.6%
9 Experimental SmallMoleculeDrug DB04417 P-Nitrophenol Thumb 22.1%
10 Experimental SmallMoleculeDrug DB03195 Phosphoric Acid Mono-[3-Fluoro-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahyro-Furan-2-Ylmethyl] Ester Thumb 21.8%
11 Experimental SmallMoleculeDrug DB04237 Tris(Hydroxyethyl)Aminomethane Thumb 21.8%
12 Experimental SmallMoleculeDrug DB08403 METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID Thumb 21.8%
13 Approved;
SmallMoleculeDrug DB11560 Lesinurad Thumb 21.7%
14 Investigational SmallMoleculeDrug DB05967 ANZ-100 Thumb 21.2%
15 Experimental SmallMoleculeDrug DB01870 1,4-dithio-alpha-D-glucopyranose Thumb 21.0%
16 Approved BiotechDrug DB08879 Belimumab Thumb 20.7%
17 Approved;
SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 20.5%
18 Approved;
Vet approved
SmallMoleculeDrug DB04224 Oleic Acid Thumb 20.5%
19 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 20.2%
20 Approved;
SmallMoleculeDrug DB00159 Icosapent Thumb 20.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.