QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q05932
No. Gene UniProt ID Protein Name Pathway PDB
1 FPGS Q05932 Folylpolyglutamate synthase, mitochondrial hsa00790; hsa01100; hsa01523 NA


2 known interactions (drugs) of input target (FPGS): Folylpolyglutamate synthase, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00293 Raltitrexed Thumb


20 predicted interactions (drugs) of input target (FPGS): Folylpolyglutamate synthase, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 34.8%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00160 L-Alanine Thumb 21.0%
3 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 19.5%
4 Approved SmallMoleculeDrug DB13146 Fluciclovine (18F) Thumb 16.8%
5 Investigational SmallMoleculeDrug DB01645 Genistein Thumb 15.8%
6 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00119 Pyruvic acid Thumb 14.8%
7 Approved;
Investigational		 SmallMoleculeDrug DB08875 Cabozantinib Thumb 14.6%
8 Approved;
Investigational		 BiotechDrug DB13998 Lonoctocog alfa Thumb 14.6%
9 Approved;
Investigational		 SmallMoleculeDrug DB11967 Binimetinib Thumb 14.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb 14.1%
11 Approved;
Investigational		 SmallMoleculeDrug DB09256 Tegafur Thumb 13.9%
12 Experimental SmallMoleculeDrug DB04530 S,S-(2-Hydroxyethyl)Thiocysteine Thumb 13.9%
13 Experimental SmallMoleculeDrug DB06928 (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID Thumb 13.8%
14 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB01065 Melatonin Thumb 13.6%
15 Approved SmallMoleculeDrug DB00322 Floxuridine Thumb 13.1%
16 Approved;
Investigational		 SmallMoleculeDrug DB09327 Tegafur-uracil Thumb 13.1%
17 Approved SmallMoleculeDrug DB01094 Hesperetin Thumb 12.9%
18 Approved;
Investigational		 SmallMoleculeDrug DB01101 Capecitabine Thumb 12.9%
19 Approved SmallMoleculeDrug DB00454 Pethidine Thumb 12.7%
20 Approved SmallMoleculeDrug DB00949 Felbamate Thumb 12.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.