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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P21802
No. Gene UniProt ID Protein Name Pathway PDB
1 FGFR2 P21802 Fibroblast growth factor receptor 2 hsa01521; hsa04010; hsa04014; hsa04015; hsa04144; hsa04151; hsa04550; hsa04810; hsa05200; hsa05215; hsa05226; hsa05230

13 known interactions (drugs) of input target (FGFR2): Fibroblast growth factor receptor 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB01901 Sucrosofate Thumb
2 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb
3 Approved;
SmallMoleculeDrug DB01109 Heparin Thumb
4 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb
5 Approved BiotechDrug DB00039 Palifermin Thumb
6 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb
7 Experimental SmallMoleculeDrug DB02058 SU4984 Thumb
8 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
9 Approved;
SmallMoleculeDrug DB01041 Thalidomide Thumb
10 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb
11 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb
12 Experimental SmallMoleculeDrug DB02491 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine Thumb
13 Approved;
SmallMoleculeDrug DB09078 Lenvatinib Thumb

20 predicted interactions (drugs) of input target (FGFR2): Fibroblast growth factor receptor 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 61.2%
2 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 47.5%
3 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 46.0%
4 Investigational SmallMoleculeDrug DB05014 XL999 Thumb 39.8%
5 Investigational SmallMoleculeDrug DB06080 ABT-869 Thumb 39.3%
6 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 38.5%
7 Experimental SmallMoleculeDrug DB07525 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine Thumb 36.2%
8 Experimental SmallMoleculeDrug DB08577 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE Thumb 35.9%
9 Approved;
SmallMoleculeDrug DB01268 Sunitinib Thumb 33.6%
10 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 31.8%
11 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 30.8%
12 Approved SmallMoleculeDrug DB00686 Pentosan Polysulfate Thumb 29.1%
13 Experimental SmallMoleculeDrug DB07840 (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol Thumb 28.9%
14 Experimental SmallMoleculeDrug DB08238 5-AMINO-NAPHTALENE-2-MONOSULFONATE Thumb 28.8%
15 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 28.3%
16 Approved;
SmallMoleculeDrug DB04868 Nilotinib Thumb 26.7%
17 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb 26.5%
18 Approved;
SmallMoleculeDrug DB08875 Cabozantinib Thumb 25.5%
19 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb 25.0%
20 Approved;
SmallMoleculeDrug DB06595 Midostaurin Thumb 25.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.