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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P42684
No. Gene UniProt ID Protein Name Pathway PDB
1 ABL2 P42684 Abelson tyrosine-protein kinase 2 hsa04012; hsa04014; hsa05416 2ECD; 2KK1; 2XYN; 3GVU; 3HMI; 3ULR; 4EIH

5 known interactions (drugs) of input target (ABL2): Abelson tyrosine-protein kinase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
3 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb
4 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb
5 Investigational SmallMoleculeDrug DB05184 XL228 Thumb

20 predicted interactions (drugs) of input target (ABL2): Abelson tyrosine-protein kinase 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 43.2%
2 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb 36.4%
3 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 33.7%
4 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 29.5%
5 Experimental SmallMoleculeDrug DB07853 [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE Thumb 24.8%
6 Approved SmallMoleculeDrug DB00619 Imatinib Thumb 23.2%
7 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 23.0%
8 Experimental SmallMoleculeDrug DB07831 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE Thumb 22.7%
9 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb 21.2%
10 Experimental SmallMoleculeDrug DB08350 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE Thumb 19.3%
11 Experimental SmallMoleculeDrug DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb 19.3%
12 Experimental SmallMoleculeDrug DB08691 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Thumb 19.1%
13 Experimental SmallMoleculeDrug DB04751 Purvalanol A Thumb 19.0%
14 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 18.8%
15 Experimental SmallMoleculeDrug DB08043 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA Thumb 18.3%
16 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 18.2%
17 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 18.1%
18 Experimental SmallMoleculeDrug DB08339 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE Thumb 17.9%
19 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 17.9%
20 Experimental SmallMoleculeDrug DB03878 N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Thumb 17.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.