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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P22888
No. Gene UniProt ID Protein Name Pathway PDB
1 LHCGR P22888 Lutropin-choriogonadotropic hormone receptor hsa04020; hsa04080; hsa04913; hsa04917 1LUT; 1XUL


7 known interactions (drugs) of input target (LHCGR): Lutropin-choriogonadotropic hormone receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00014 Goserelin Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00050 Cetrorelix Thumb
3 Approved BiotechDrug DB00044 Lutropin alfa Thumb
4 Approved;
Vet approved		 BiotechDrug DB09126 Chorionic Gonadotropin (Human) Thumb
5 Approved;
Investigational		 BiotechDrug DB06719 Buserelin Thumb
6 Approved BiotechDrug DB00032 Menotropins Thumb
7 Approved BiotechDrug DB00097 Choriogonadotropin alfa Thumb


20 predicted interactions (drugs) of input target (LHCGR): Lutropin-choriogonadotropic hormone receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 26.5%
2 ;
histrelina;
histreline;
histrelinum;
L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-Nim-benzyl-histidyl-L-leucyl-L-arginyl-L-proline ethylamide		 SmallMoleculeDrug DB06788 Histrelin Thumb 25.3%
3 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00106 Abarelix Thumb 22.9%
4 Approved SmallMoleculeDrug DB11619 Gestrinone Thumb 22.2%
5 Investigational SmallMoleculeDrug DB05624 Teverelix Thumb 22.1%
6 Approved;
Investigational		 SmallMoleculeDrug DB11979 Elagolix Thumb 20.7%
7 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 20.1%
8 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 20.1%
9 Approved SmallMoleculeDrug DB06785 Ganirelix Thumb 20.1%
10 Investigational BiotechDrug DB04959 HspE7 Thumb 19.8%
11 Approved SmallMoleculeDrug DB00973 Ezetimibe Thumb 19.6%
12 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 19.6%
13 Approved;
Investigational		 BiotechDrug DB00042 Botulinum Toxin Type B Thumb 19.6%
14 Investigational SmallMoleculeDrug DB06494 Sufugolix Thumb 18.8%
15 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00644 Gonadorelin Thumb 18.8%
16 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 18.8%
17 Approved;
Nutraceutical		 SmallMoleculeDrug DB00117 Histidine Thumb 18.7%
18 Approved;
Investigational		 BiotechDrug DB00007 Leuprolide Thumb 18.7%
19 Investigational SmallMoleculeDrug DB05483 PCL-016 Thumb 18.5%
20 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 18.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.